Colgate Laboratory Tests Show Toothpaste and Mouthwash Neutralize 99.9% of the Virus That Causes COVID-19
20 November 2020 - 4:36AM
Business Wire
Clinical Research Program Underway To Validate
Potential of Oral Health Products to Slow Spread of the Virus
Laboratory studies show that toothpastes containing zinc or
stannous and mouthwash formulas with cetylpyridinium chloride (CPC)
neutralize the virus that causes COVID-19 by 99.9 percent. The
studies are part of a Colgate research program that includes
clinical studies among infected people to assess the efficacy of
oral care products in reducing the amount of the virus in the
mouth, potentially slowing the transmission of the COVID-19
virus.
In the laboratory studies -- the first to include toothpaste --
Colgate Total and Meridol toothpastes neutralized 99.9% of the
virus after two minutes of contact. Colgate Plax and Colgate Total
mouthwashes were similarly effective after 30 seconds. The studies,
completed in October, were conducted in partnership with Rutgers
New Jersey Medical School’s (NJMS) Public Health Research Institute
and Regional Biosafety Laboratories.
The results suggest that some toothpastes and mouthwashes may
help reduce the spread of SARS-CoV-2, the virus that causes
COVID-19, by temporarily reducing the amount of virus in the mouth.
The virus spreads through respiratory droplets or small particles
produced when an infected person coughs, sneezes, sings, talks, or
breathes, according to the U.S. Centers for Disease Control and
Prevention.
“We’re at the early stages of our clinical investigations, but
our preliminary laboratory and clinical results are very
promising,” said Dr. Maria Ryan, Colgate’s Chief Clinical Officer.
“While brushing and rinsing are not a treatment or a way to fully
protect an individual from infection, they may help to reduce
transmission and slow the spread of the virus, supplementing the
benefit we get from wearing masks, social distancing and frequent
hand washing.”
Said Dr. David Alland, Chief of Infectious Diseases and Director
of the Center for COVID-19 Response and Pandemic Preparedness, who
led the Rutgers NJMS study along with colleagues Drs. Pradeep Kumar
and Riccardo Russo: “Given that saliva can contain amounts of virus
that are comparable to that found in the nose and throat, it seems
likely that SARS-CoV-2 virus originating in the mouth contributes
to disease transmission, especially in persons with asymptomatic
COVID-19, who are not coughing. This suggests that reducing virus
in the mouth could help prevent transmission during the time that
oral care products are active.”
Concurrent to the laboratory study, Colgate sponsored a clinical
study involving some 50 hospitalized subjects with COVID-19. This
study demonstrated the ability of Colgate Total (with CPC and
zinc), Colgate Peroxyl, and Colgate PerioGard mouthwashes to
substantially reduce the amount of the virus in the mouth
temporarily. The researchers plan to share their findings in
December. Additional Colgate-supported clinical research studies on
toothpaste and mouthwashes are in early stages at Rutgers, the
Albert Einstein Institute in Sao Paulo, Brazil, and at the
University of North Carolina at Chapel Hill Adams School of
Dentistry, with some 260 people with COVID-19 participating in
these studies.
“Colgate is collaborating with numerous investigators throughout
the globe to conduct clinical research to explore the potential of
oral care products to reduce oral viral loads as a risk reduction
strategy,” Dr. Ryan said. “We think oral care has a role to play in
fighting the global pandemic, alongside other preventive
measures.”
Said Dr. Mark Wolff, Morton Amsterdam Dean of Penn Dental
Medicine at the University of Pennsylvania: “With this pandemic,
the more we understand about the virus, the more effective we can
be in fighting it, so I am excited to see the impressive research
program Colgate has undertaken. We need to continue to take the
precautions recommended by health authorities, and with these
studies we may demonstrate an additional way to address the
transmission of disease among people in close contact, particularly
in dental practice. That would be an important advance.”
As the world’s #1 trusted dental expert, Colgate is committed to
leading in science and to ensuring that its products address health
challenges and meet consumers’ needs. For more information about
the effects of oral hygiene on overall health and additional
insights on mask mouth and other topics, visit www.colgate.com.
About Colgate-Palmolive:
Colgate-Palmolive Company is a caring, innovative growth company
reimagining a healthier future for all people, their pets and our
planet. Focused on Oral Care, Personal Care, Home Care and Pet
Nutrition and reaching more than 200 countries and territories,
Colgate teams are developing and selling health and hygiene
products and pet nutrition offerings essential to society through
brands such as Colgate, Palmolive, elmex, meridol, Tom’s of Maine,
hello, Sorriso, Speed Stick, Softsoap, Irish Spring, Protex, Sanex,
Filorga, eltaMD, PCA Skin, Ajax, Axion, Fabuloso, Soupline and
Suavitel, as well as Hill’s Science Diet and Hill’s Prescription
Diet. Colgate seeks to deliver sustainable, profitable growth and
superior shareholder returns and to provide Colgate people with an
innovative and inclusive work environment. Colgate does this by
developing and selling products globally that make people’s lives
healthier and more enjoyable and by embracing its sustainability,
diversity, equity and inclusion and social responsibility
strategies across the organization. For more information about
Colgate’s global business, its efforts to improve the oral health
of children through its Bright Smiles, Bright Futures program and
how the Company is building a future to smile about, visit
www.colgatepalmolive.com. CL-C
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