Karolinska Development’s portfolio company Umecrine Cognition presents data on golexanolone’s mode-of-action and ability to reduce neuroinflammation
07 June 2023 - 10:01PM
Karolinska Development’s portfolio company Umecrine Cognition
presents data on golexanolone’s mode-of-action and ability to
reduce neuroinflammation
STOCKHOLM, SWEDEN – June 7, 2023. Karolinska Development AB
(Nasdaq Stockholm: KDEV) today announces that its portfolio company
Umecrine Cognition has announced results from a preclinical model
of cholestasis that elucidates the mechanism-of-action of the
company’s clinical drug candidate golexanolone in cholestatic liver
disease. The results will be presented as a poster during the
International Liver Congress EASL in Vienna, June 21-24.
Umecrine Cognition is developing a new class of drugs to
alleviate cognitive symptoms caused by liver disease. The company's
most advanced drug candidate, golexanolone, is currently being
evaluated in primary biliary cholangitis (PBC) and hepatic
encephalopathy (HE).
The results from the preclinical study showed that golexanolone
reversed the increase of several pro-inflammatory interleukins and
reversed specific alterations in GABAergic neurotransmission
in the cerebellum. Golexanolone also reduced the content of
pro-inflammatory factors in the cerebellum. These findings are
following previously reported mechanisms of golexanolone and
further elucidate the mechanism-of-action of golexanolone in
reversing fatigue and improving short-term memory in cholestatic
liver diseases.
“The current findings suggest a mechanism-of-action of
golexanolone and show that the drug candidate may have beneficial
effects on fatigue well as motor and cognitive impairment in
patients with cholestatic liver disease,” says Viktor Drvota, CEO
of Karolinska Development.
Karolinska Development's ownership in Umecrine
Cognition amounts to 73 percent.
For further information, please
contact:
Viktor Drvota, CEO, Karolinska Development AB Phone: +46 73 982
52 02, e-mail: viktor.drvota@karolinskadevelopment.com
Johan Dighed, General Counsel and Deputy CEO, Karolinska
Development ABPhone: +46 70 207 48 26, e-mail:
johan.dighed@karolinskadevelopment.com
TO THE EDITORS
About Karolinska Development ABKarolinska
Development AB (Nasdaq Stockholm: KDEV) is a Nordic life sciences
investment company. The company focuses on identifying breakthrough
medical innovations in the Nordic region that are developed by
entrepreneurs and leadership teams. The Company invests in the
creation and growth of companies that advance these assets into
commercial products that are designed to make a difference to
patient’s lives while providing an attractive return on investment
to shareholders.
Karolinska Development has access to world-class medical
innovations at the Karolinska Institutet and other leading
universities and research institutes in the Nordic region. The
Company aims to build companies around scientists who are leaders
in their fields, supported by experienced management teams and
advisers, and co-funded by specialist international investors, to
provide the greatest chance of success.
Karolinska Development has a portfolio of eleven companies
targeting opportunities in innovative treatment for
life-threatening or serious debilitating diseases.
The Company is led by an entrepreneurial team of investment
professionals with a proven track record as company builders and
with access to a strong global network.
For more information, please visit
www.karolinskadevelopment.com.
- KD Umecrine Cognition Wien poster eng
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