UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 6-K
Report of Foreign Private Issuer
Pursuant to Rule 13a-16 or 15d-16
Under the Securities Exchange Act of 1934
For the Month of August 2024
001-36203
(Commission File Number)
CAN-FITE BIOPHARMA LTD.
(Exact name of Registrant as specified in its charter)
26 Ben Gurion Street
Ramat Gan 5257346 Israel
(Address of principal executive offices)
Indicate by check mark whether the registrant
files or will file annual reports under cover Form 20-F or Form 40-F.
Form 20-F ☒ Form 40-F ☐
This Report on Form 6-K (including
exhibits attached hereto) is hereby incorporated by reference into the registrant’s Registration Statements on
Form S-8 (File Nos. 333-227753, 333-271384 and 333-278525) and Form F-3 (File
Nos. 333-236064, 333-274316, 333-262055 and 333-276000), to be a part thereof from the date on which
this report is submitted, to the extent not superseded by documents or reports subsequently filed or furnished.
On August 30, 2024, Can-Fite
BioPharma Ltd. (the “Company”) entered into an At The Market Offering Agreement (the “Offering Agreement”) with
H.C. Wainwright & Co., LLC, as sales agent (“Wainwright”), pursuant to which the Company may offer and sell, from time
to time through Wainwright American Depositary Shares, each representing three hundred ordinary shares of the Company, no par value (the
“Ordinary Shares”), having an aggregate offering price of up to $9.0 million (the “ADSs”).
The offer and sale of
the ADSs will be made pursuant to a shelf registration statement on Form F-3 and the related prospectus (File No. 333-274316) filed by
the Company with the Securities and Exchange Commission (the “SEC”) on September 1, 2023, and declared effective by the SEC
on September 12, 2023, as supplemented by a prospectus supplement dated August 30, 2024, filed with the SEC pursuant to Rule 424(b) under
the Securities Act of 1933, as amended (the “Securities Act”).
Pursuant to the Offering
Agreement, sales of ADSs may be made in transactions that are deemed to be “at-the-market” offerings as defined in Rule 415
under the Securities Act, including sales made directly on or through The Nasdaq Capital Market, or any other existing trading market
in the Unites States for the Company’s ADSs, sales made to or through a market maker other than on an exchange or otherwise, directly
to Wainwright as principal, in negotiated transactions at market prices prevailing at the time of sale or at prices related to such prevailing
market prices and/or in any other method permitted by law. Wainwright will use commercially reasonable efforts consistent with its normal
trading and sales practices and applicable law and regulations to sell the ADSs pursuant to the Offering Agreement from time to time,
based upon instructions from the Company, including any price or size limits or other customary parameters or conditions the Company may
impose.
The offering of ADSs
pursuant to the Offering Agreement will terminate upon the earliest of (a) the termination of the Offering Agreement by Wainwright or
the Company, as permitted therein, and (b) the mutual agreement of the parties. The Company will pay Wainwright a fixed commission rate
equal to 3.0% of the gross sales price of the ADSs sold pursuant to the Offering Agreement and has agreed to provide Wainwright with
customary indemnification and contribution rights.
The Company will also
reimburse Wainwright for certain specified expenses in connection with entering into the Offering Agreement. The Offering Agreement contains
customary representations and warranties and conditions to the sale of the ADSs pursuant thereto.
The foregoing description of the Offering Agreement is not complete and is qualified in its entirety by reference to the full text of
such agreement, a copy of which is filed herewith as Exhibit 10.1 to this Report on Form 6-K and is incorporated herein by reference.
A copy of the opinion of Doron, Tikotzky, Kantor, Gutman, Amit Gross & Co. relating to the offer and sale of the ADSs is attached
as Exhibit 5.1 hereto.
This Report on Form 6-K
shall not constitute an offer to sell, or the solicitation of an offer to buy, the ADSs discussed herein, nor shall there be any offer,
solicitation, or sale of securities in any state in which such offer, solicitation or sale would be unlawful prior to registration or
qualification under the securities laws of any such state.
Exhibit Index
Exhibit No. |
|
Description |
5.1 |
|
Opinion of Doron, Tikotzky, Kantor, Gutman, Amit Gross & Co. |
10.1 |
|
Form of At The Market Offering
Agreement, dated August 30, 2024, between Can-Fite BioPharma Ltd. and H.C. Wainwright & Co., LLC |
23.1 |
|
Consent of Doron, Tikotzky, Kantor, Gutman, Amit Gross & Co. (included in Exhibit 5.1) |
SIGNATURES
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto
duly authorized.
Date: August 30, 2024 |
By: |
/s/ Motti Farbstein |
|
|
Motti Farbstein |
|
|
Chief Executive Officer and Chief Financial Officer |
2
Exhibit 5.1
Yaron
Tikotzky, Adv. (CPA)*
Eli Doron, Adv. &
Notary
Ronen Kantor, Adv.
Amit Gross, Adv. &
Notary
Giora Gutman, Adv.
Rami Arie, Adv. (CPA)
Rachel (Goren) Cavallero,
Adv.
Gil Mor, Adv. &
Notary**
Sharon Fishman, Adv.
& Notary
Efrat Hamami, Adv.
Tamir Kalderon, Adv.
Asaf Gershgoren, Adv.
& economist
Efi Ohana, Adv. &
economist
Asaf Hofman, Adv.
& economist
Moti Philip, Adv.
Shai Glikman, Adv.
Rotem Nissim, Adv.
Hadas Garoosi, Adv.
Shmulik Cohen, Adv.
Izhak Lax, Adv.
Amit Moshe Cohen,
Adv.
Shimon Gros, Adv.
& Notary
Shahar Noah, Adv.
(Tax advisor)
Igal Rosenberg, Adv.
Ori Perel, Adv.
Shai Pnini, Adv.
Sandrine Dray, Adv.
Mediator & Notary***
Nahi Hamud, Adv.
Yair Messalem, Adv.
Maayan Peled, Adv.
Liav Menachem, Adv.
Notary & Mediator
Israel Asraf, Adv.
& Notary
Gali Ganoni, Adv.
Odelia Cohen-Schondorf,
Adv.
Yana Shapiro Orbach,
Adv.
Roy Galis, Adv.
Oren Geni, Adv.
Moran Ovadia, Adv.
Sonny Knaz, Adv.
Bat-El Ovadia, Adv.
Aharon Eitan, Adv.
Rania Elime, Adv.
Haim Pesenzon, Adv.
Shaike Rakovsky, Adv.
Ronit Rabinovich,
Adv.
Iris Borcom, Adv.
Omri Alter, Adv.
Shira Ben dov levi,
Adv.
Inbal Naim, Adv.
Yonatan Gamarnik,
Adv.
Ben Mugraby, Adv.
Shirli Shlezinger,
Adv.
Michael Misul , Adv.
Jacob Bayarsky, Adv.
& economist
Matan Hemo, Adv.
Tamir Shenhav, Adv.
Adi Ben yair- Yosef,
Adv
Moshe Zoaretz, Adv.
Nina Aharonov, Adv.
Rozit kabudi Doron,
Adv.
Doron Pesso, Adv.
Adi Barnes-Ovdat,
Adv.
Omri Yacov, Adv.
Noy Keren, Adv.
Liat Ingber, Adv.
Lipaz Elimelch-Karni,
Adv.
Eli Hirsch, Adv.
Maayan Gadalov,Adv.
Dov Alter, Adv.
Monica kevorkian karawani,
Adv.
Shahaf Zuker, Adv.
Alexey Kvaktoun, Adv.
Elinor Yaakobi, Adv.
Dor Elkrif; Adv.
Netanel Rozenberg,
Adv.
Gil Friedman, Adv.
Hadar Raz, Adv.
Ilia Parkhomyuk, Adv.
Dana Hofman, Adv.
shirly Lipovetsky,
Adv.
Yamit Halperin, Adv.
Moran Alezra, Adv.
Elinor Palma, Adv.
Lidor Amar, Adv.
Tali Kadosh, Adv.
Rami Zoabi, Adv.
Michelle Zohar-Peer,
Adv.
Barak Harari, Adv.
Ayala Meidan-Greenshpan,
Adv.
Coral Opal, Adv.
Eden Eliad, Adv.
Eli Kulas. Adv. Notary
& Mediator – Of Counsel
Eli Chenchinski, Adv.
- Of Counsel
Yaacov Wagner, Senior
judge (retired), Adv.- L.L.M, Mediator & Arbitrator- Of Counsel
Jan Robinsohn, M.Jur.
Adv. & Notary - Of Counsel
****
Giora Amir (1928-2020)
* Member of the New
York State Bar
** Member of the Law
Society in England & Wales
*** Accredited by
the consulate of France
**** Honorary Consul Of
The Republic
Of Poland
(ret.)
|
|
Bnei Brak, August 30, 2024
To: Can-Fite Biopharma Ltd.
26 Ben Gurion Street.
Ramat Gan 5257346 Israel
Ladies and Gentlemen,
We have acted as Israeli counsel
to Can-Fite Biopharma Ltd. (the “Company”), a company organized under the laws of the State of Israel in connection
with the offer, issuance and sale, from time to time, of up to $9,000,000 American Depositary Shares (“ADSs”), each
representing three hundred (300) ordinary shares of no par value (the “Ordinary Shares”) pursuant to the At The Market
Offering Agreement dated August 30, 2024 (the “Sales Agreement”). The Offering is being effected pursuant to a Registration
Statement on Form F-3 (File No. 333-274316) (the “Registration Statement”), filed by the Company with the Securities
and Exchange Commission (the “Commission”) on September 1, 2023, the base prospectus, contained therein and, forming
a part thereof (the “Base Prospectus”), (iii) the prospectus supplement, dated August 30, 2024, in the form filed with
the Commission on August 30, 2024 (the “Prospectus Supplement” and together with the Base Prospectus, the “Prospectus”)
(the “Offering”).
This opinion letter is furnished
to you at your request to enable you to fulfill the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act, in connection
with the filing of the Registration Statement.
In connection herewith, we
have examined the originals, or photocopies or copies, certified or otherwise identified to our satisfaction, of: (i) the Registration
Statement; (ii) the Prospectus; (iii) the Sales Agreement; (iv) the articles of association of the Company, as currently in effect (the
“Articles”); (v) resolutions of the board of directors (the “Board”) of the Company which have heretofore
been approved and relate to the Registration Statement, the Prospectus and other actions to be taken in connection with the Offering;
and (vi) such other corporate records, agreements, documents and other instruments, and such certificates or comparable documents of public
officials and of officers of the Company as we have deemed relevant and necessary as a basis for the opinions hereafter set forth. We
have also made inquiries of such officers as we have deemed relevant and necessary as a basis for the opinions hereafter set forth.
In such examination, we have
assumed the genuineness of all signatures, the legal capacity of all natural persons, the authenticity of all documents submitted to us
as originals, the conformity to original documents of all documents submitted to us as certified, confirmed as photostatic copies and
the authenticity of the originals of such latter documents. As to all questions of fact material to these opinions that have not been
independently established, we have relied upon certificates or comparable documents of officers and representatives of the Company.
Based upon and subject to
the foregoing, we are of the opinion that, assuming that prior to the issuance and sale of any of ADSs under the Sales Agreement, the
price, number of ADSs and certain other terms of issuance with respect to any specific placement notice delivered under the Sales Agreement
will be authorized and approved by the Board or a pricing committee of the Board in accordance with Israeli law, all corporate proceedings
necessary for the authorization, issuance and delivery of the Ordinary Shares underlying the ADSs shall have been taken upon issuance
pursuant to the terms of the Sales Agreement against payment of the consideration set forth in the Sales Agreement and in accordance with
resolutions of the Board related to the Offering, the Ordinary Shares underlying the ADSs will be validly issued, fully paid and non-assessable
and, are not subject to any preemptive rights, rights of first refusal or other similar rights of any securityholder of the Company pursuant
to the Company’s currently effective Articles, Israeli law or the documents governed by the laws of the State of Israel.
|
|
mail@dtkgg.com
www.dtkgg.com |
Haifa
& Northern: 7 Palyam Blvd. Haifa,
(Phoenix
House) 7th Floor, 3309510
Tel.
+972-4-8147500 | Fax 972-4-8555976
Banking
& Collection, 6th Floor
Tel.
972-4-8353700 | Fax 972-4-8702477
Romania:
7 Franklin, 1st District, Bucharest
Cyprus:
9 Zenonos Kitieos St., 2406 Engomi, Nicosia |
Central:
B.S.R. Tower 4, 33th Floor,
7 metsada St. Bnei
Brak, 5126112
Tel. 972-3-6109100
| Fax +972-3-6127449
Tel. 972-3-6133371
| Fax +972-3-6133372
Tel. 972-3-7940700
| Fax +972-3-7467470
Tel. 972-3-6114455
| Fax +972-3-6131170
Austria:
Wildpretmarkt 2-4 | Mezzanin, A-1010 , Vienna |
With respect to our opinion
as to the Ordinary Shares underlying the ADSs, we have assumed that, at the time of issuance and sale and to the extent any such issuance
would exceed the maximum share capital of the Company currently authorized, the number of Ordinary Shares that the Company is authorized
to issue shall have been increased in accordance with the Articles such that a sufficient number of Ordinary Shares are authorized and
available for issuance under the Articles.
Members of our firm are admitted
to the Bar in the State of Israel, and we do not express any opinion as to the laws of any other jurisdiction. This opinion is limited
to the matters stated herein and no opinion is implied or may be inferred beyond the matters expressly stated.
We consent to the filing of
this opinion as an exhibit to the Registration Statement (as an exhibit to a Report of Foreign Private Issuer on Form 6-K that is incorporated
by reference in the Registration Statement) and to the reference to our firm appearing under the caption “Legal Matters” in
the Prospectus. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required under
Section 7 of the Securities Act, the rules and regulations of the Commission promulgated thereunder or Item 509 of the Commission’s
Regulation S-K under the Securities Act.
This opinion letter is rendered
as of the date hereof and we disclaim any obligation to advise you of facts, circumstances, events or developments that may be brought
to our attention after the date of the Prospectus that may alter, affect or modify the opinions expressed herein.
Sincerely,
/s/ Doron, Tikotzky,
Kantor, Gutman, Amit Gross & Co.,
Advocates & Notaries
Exhibit 10.1
AT THE MARKET OFFERING AGREEMENT
August 30,
2024
H.C. Wainwright & Co., LLC
430 Park Avenue
New York, New York 10022
Ladies and
Gentlemen:
Can-Fite Biopharma Ltd., a
corporation organized under the laws of the State of Israel (the “Company”), confirms its agreement (this “Agreement”)
with H.C. Wainwright & Co., LLC (the “Manager”) as follows:
1. Definitions.
The terms that follow, when used in this Agreement and any Terms Agreement, shall have the meanings indicated.
“Accountants” shall
have the meaning ascribed to such term in Section 4(m).
“Act”
shall mean the Securities Act of 1933, as amended, and the rules and regulations of the Commission promulgated thereunder.
“Action”
shall have the meaning ascribed to such term in Section 3(p).
“ADS(s)”
means American Depositary Shares issued pursuant to the Deposit Agreement (as defined below), each representing three hundred (300) Ordinary
Shares.
“Affiliate”
shall have the meaning ascribed to such term in Section 3(o).
“Applicable
Time” shall mean, with respect to any ADSs, the time of sale of such ADSs pursuant to this Agreement or any relevant Terms Agreement.
“Base Prospectus”
shall mean the base prospectus contained in the Registration Statement at the Execution Time.
“Board”
shall have the meaning ascribed to such term in Section 2(b)(iii).
“Broker
Fee” shall have the meaning ascribed to such term in Section 2(b)(v).
“Business
Day” shall mean any day other than Saturday, Sunday or other day on which commercial banks in The City of New York or the State
of Israel are authorized or required by law to remain closed; provided, however, that, for purposes of clarity, commercial
banks shall not be deemed to be authorized or required by law to remain closed due to “stay at home”, “shelter-in-place”,
“non-essential employee” or any other similar orders or restrictions or the closure of any physical branch locations
at the direction of any governmental authority so long as the electronic funds transfer systems (including for wire transfers) of commercial
banks in The City of New York generally are open for use by customers on such day.
“Commission”
shall mean the United States Securities and Exchange Commission.
“Company
Israeli Counsel” means Doron, Tikotzky, Kantor, Gutman, Amit Gross and Co., with offices located at B.S.R. 4 Tower, 33rd Floor,
7 Metsada Street, Bnei Brak 5126112 Israel.
“Company
U.S. Counsel” means Greenberg Traurig, P.A., with offices located at One Azrieli Center, Round Tower, 30th floor, 132 Menachem
Begin Rd, Tel Aviv 6701101.
“Deposit
Agreement” means the Deposit Agreement, dated as of September 19, 2012, as amended and restated as of September 11, 2013, among
the Company, The Bank of New York Mellon, as Depositary, and the owners and holders of ADSs from time to time, as such agreement may be
amended or supplemented.
“Depositary”
means The Bank of New York Mellon, as Depositary under the Deposit Agreement, and any successor as depositary under the Deposit Agreement.
“Depositary’s
Counsel” shall mean Emmet, Marvin & Martin, LLP, with offices located at 120 Broadway, New York, New York 10271.
“DTC”
shall have the meaning ascribed to such term in Section 2(b)(vii).
“Effective
Date” shall mean each date and time that the Registration Statement and any post-effective amendment or amendments thereto became
or becomes effective.
“Exchange
Act” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations of the Commission promulgated
thereunder.
“Execution
Time” shall mean the date and time that this Agreement is executed and delivered by the parties hereto.
“Free Writing
Prospectus” shall mean a free writing prospectus, as defined in Rule 405.
“GAAP”
shall have the meaning ascribed to such term in Section 3(m).
“Incorporated
Documents” shall mean the documents or portions thereof filed with the Commission on or prior to the Effective Date that are
incorporated by reference in the Registration Statement or the Prospectus and any documents or portions thereof filed with the Commission
after the Effective Date that are deemed to be incorporated by reference in the Registration Statement or the Prospectus.
“Intellectual
Property Rights” shall have the meaning ascribed to such term in Section 3(v).
“Issuer
Free Writing Prospectus” shall mean an issuer free writing prospectus, as defined in Rule 433.
“Losses”
shall have the meaning ascribed to such term in Section 7(d).
“Material
Adverse Effect” shall have the meaning ascribed to such term in Section 3(b).
“Material
Permits” shall have the meaning ascribed to such term in Section 3(t).
“Net Proceeds”
shall have the meaning ascribed to such term in Section 2(b)(v).
“Ordinary
Shares” means the ordinary shares of the Company, no par value, and any other class of securities into which such securities
may hereafter be reclassified or changed.
“Ordinary
Share Equivalents” means any securities of the Company or the Subsidiaries which would entitle the holder thereof to acquire
at any time Ordinary Shares or ADSs, including, without limitation, any debt, preferred shares, right, option, warrant or other instrument
that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive, Ordinary
Shares or ADSs.
“Permitted
Free Writing Prospectus” shall have the meaning ascribed to such term in Section 4(g).
“Placement”
shall have the meaning ascribed to such term in Section 2(c).
“Proceeding”
shall have the meaning ascribed to such term in Section 3(b).
“Prospectus”
shall mean the Base Prospectus, as supplemented by the most recently filed Prospectus Supplement (if any).
“Prospectus
Supplement” shall mean each prospectus supplement relating to the Ordinary Shares represented by ADSs prepared and filed pursuant
to Rule 424(b) from time to time.
“Registration
Statement” shall mean the shelf registration statement (File Number 333-274316) on Form F-3, including exhibits and
financial statements filed with or incorporated by reference into such registration statement and any prospectus supplement relating to
the Ordinary Shares represented by ADSs that is filed with the Commission pursuant to Rule 424(b) and deemed part of such registration
statement pursuant to Rule 430B, as amended on each Effective Date and, in the event any post-effective amendment thereto becomes
effective, shall also mean such registration statement as so amended.
“Representation
Date” shall have the meaning ascribed to such term in Section 4(k).
“Required
Approvals” shall have the meaning ascribed to such term in Section 3(e).
“Rule 158”,
“Rule 164”, “Rule 172”, “Rule 173”, “Rule 405”,
“Rule 415”, “Rule 424”, “Rule 430B” and “Rule 433”
refer to such rules under the Act.
“Sales
Notice” shall have the meaning ascribed to such term in Section 2(b)(i).
“SEC Reports”
shall have the meaning ascribed to such term in Section 3(m).
“Settlement
Date” shall have the meaning ascribed to such term in Section 2(b)(vii).
“Subsidiary”
shall have the meaning ascribed to such term in Section 3(a).
“Terms
Agreement” shall have the meaning ascribed to such term in Section 2(a).
“Time of
Delivery” shall have the meaning ascribed to such term in Section 2(c).
“Trading
Day” means a day on which the Trading Market is open for trading.
“Trading
Market” means whichever of the New York Stock Exchange, the NYSE American, the Nasdaq Global Select Market, the Nasdaq Global
Market or the Nasdaq Capital Market on which the ADSs are listed or quoted for trading on the date in question.
2. Sale
and Delivery of ADSs. The Company proposes to issue and sell through or to the Manager, as sales agent and/or principal, from time
to time during the term of this Agreement and on the terms set forth herein, up to such number of Ordinary Shares represented by ADSs
that does not exceed (a) the number or dollar amount of ADSs representing the amount of Ordinary Shares registered on the Prospectus Supplement,
pursuant to which the offering is being made, (b) the maximum number of Ordinary Shares represented by ADSs authorized for issuance hereunder
and representing the maximum number of authorized but unissued Ordinary Shares (less the number of Ordinary Shares issuable upon exercise,
conversion or exchange of any outstanding securities of the Company or otherwise reserved from the Company’s authorized Ordinary
Shares), or (c) the number or dollar amount of ADSs representing the maximum number of Ordinary Shares that would cause the Company or
the offering of the ADSs to not satisfy the eligibility and transaction requirements for use of Form F-3, including, if applicable, General
Instruction I.B.5 of Registration Statement on Form F-3 (the lesser of (a), (b) and (c), the “Maximum Amount”). Notwithstanding
anything to the contrary contained herein, the parties hereto agree that compliance with the limitations set forth in this Section 2 on
the number and aggregate sales price of ADSs issued and sold under this Agreement shall be the sole responsibility of the Company and
that the Manager shall have no obligation in connection with such compliance.
(a) Appointment
of Manager as Selling Agent; Terms Agreement. For purposes of selling the ADSs through the Manager, the Company hereby appoints the
Manager as exclusive agent of the Company for the purpose of selling the ADSs pursuant to this Agreement and the Manager agrees to use
its commercially reasonable efforts to sell the ADSs on the terms and subject to the conditions stated herein. The Company agrees that,
whenever it determines to sell the ADSs directly to the Manager as principal, it will enter into a separate agreement (each, a “Terms
Agreement”) in substantially the form of Annex I hereto, relating to such sale in accordance with Section 2 of this
Agreement.
(b) Agent
Sales. Subject to the terms and conditions and in reliance upon the representations and warranties herein set forth, the Company will
issue and agrees to sell ADSs from time to time through the Manager, acting as sales agent, and the Manager agrees to use its commercially
reasonable efforts to sell, as sales agent for the Company, on the following terms:
(i) The
ADSs are to be sold on a daily basis or otherwise as shall be agreed to by the Company and the Manager on any day that (A) is a Trading
Day, (B) the Company has instructed the Manager by telephone (confirmed promptly by electronic mail) to make such sales (“Sales
Notice”) and (C) the Company has satisfied its obligations under Section 6 of this Agreement. The Company will designate the
maximum amount of the ADSs to be sold by the Manager daily (subject to the limitations set forth in Section 2(d)) and the minimum price
per ADS at which such ADSs may be sold. Subject to the terms and conditions hereof, the Manager shall use its commercially reasonable
efforts to sell on a particular day all of the ADSs designated for the sale by the Company on such day. The gross sales price of the ADSs
sold under this Section 2(b) shall be the market price for the ADSs sold by the Manager under this Section 2(b) on the Trading
Market at the time of sale of such ADSs.
(ii) The
Company acknowledges and agrees that (A) there can be no assurance that the Manager will be successful in selling the ADSs, (B) the
Manager will incur no liability or obligation to the Company or any other Person if it does not sell the ADSs for any reason other than
a failure by the Manager to use its commercially reasonable efforts consistent with its normal trading and sales practices and applicable
law and regulations to sell such ADSs as required under this Agreement, and (C) the Manager shall be under no obligation to purchase
ADSs on a principal basis pursuant to this Agreement, except as otherwise specifically agreed by the Manager and the Company pursuant
to a Terms Agreement.
(iii) The
Company shall not authorize the issuance and sale of, and the Manager shall not be obligated to use its commercially reasonable efforts
to sell, any ADS at a price lower than the minimum price therefor designated from time to time by the Company’s Board of Directors
(the “Board”), or a duly authorized committee thereof, or such duly authorized officers of the Company, and notified
to the Manager in writing. The Company or the Manager may, upon notice to the other party hereto by telephone (confirmed promptly by electronic
mail), suspend the offering of the ADSs for any reason and at any time; provided, however, that such suspension or termination
shall not affect or impair the parties’ respective obligations with respect to the ADSs sold hereunder prior to the giving of such
notice.
(iv) The
Manager may sell ADSs by any method permitted by law deemed to be an “at the market offering” as defined in Rule 415
under the Act, including without limitation sales made directly on the Trading Market, on any other existing trading market for the ADSs
or to or through a market maker. The Manager may also sell ADSs in privately negotiated transactions, provided that the Manager receives
the Company’s prior written approval for any sales in privately negotiated transactions and if so provided in the “Plan of
Distribution” section of the Prospectus Supplement or a supplement to the Prospectus Supplement or a new Prospectus Supplement disclosing
the terms of such privately negotiated transaction.
(v) The
compensation to the Manager for sales of the ADSs under this Section 2(b) shall be a placement fee of 3.0% of the gross sales price of
the ADSs sold pursuant to this Section 2(b) (“Broker Fee”). The foregoing rate of compensation shall not apply when
the Manager acts as principal, in which case the Company may sell ADSs to the Manager as principal at a price agreed upon at the relevant
Applicable Time pursuant to a Terms Agreement. The remaining proceeds, after deduction of the Broker Fee and deduction of any transaction
fees imposed by any clearing firm, execution broker, or governmental or self-regulatory organization in respect of such sales, shall constitute
the net proceeds to the Company for such ADSs (the “Net Proceeds”).
(vi) The
Manager shall provide written confirmation (which may be by facsimile or electronic mail) to the Company following the close of trading
on the Trading Market each day in which the ADSs are sold under this Section 2(b) setting forth the number of the ADSs sold on such day,
the aggregate gross sales proceeds and the Net Proceeds to the Company, and the compensation payable by the Company to the Manager with
respect to such sales.
(vii) Unless
otherwise agreed between the Company and the Manager, settlement for sales of the ADSs will occur at 10:00 a.m. (New York City time) on
the first (1st) Trading Day (or any such shorter settlement cycle as may be in
effect pursuant to Rule 15c6-1 under the Exchange Act from time to time) following the date on which such sales are made (each,
a “Settlement Date”). On or before the Trading Day prior to each Settlement Date, the Company will, or will cause (to
the extent possible) its transfer agent to, issue and deposit with the Depositary’s custodian the number of Ordinary Shares to represented
by the ADSs being sold and instruct the Depositary to deliver that number of ADSs by crediting the Manager’s or its designee’s
account (provided that the Manager shall have given the Company written notice of such designee at least one Trading Day prior to the
Settlement Date) at The Depository Trust Company (“DTC”) through its Deposit and Withdrawal at Custodian System or
by such other means of delivery as may be mutually agreed upon by the parties hereto which ADSs in all cases shall be freely tradable,
transferable, registered ADSs in good deliverable form. On each Settlement Date, the Manager will deliver the related Net Proceeds in
same day funds to an account designated by the Company. The Company agrees that, if the Company, or its transfer agent (if applicable),
defaults in its obligation to deliver duly authorized ADSs on a Settlement Date, in addition to and in no way limiting the rights and
obligations set forth in Section 7 hereto, the Company will (i) hold the Manager harmless against any loss, claim, damage, or reasonable,
documented expense (including reasonable and documented legal fees and expenses), as incurred, arising out of or in connection with such
default by the Company, and (ii) pay to the Manager any commission, discount or other compensation to which the Manager would otherwise
have been entitled absent such default.
(viii) At
each Applicable Time, Settlement Date, and Representation Date, the Company shall be deemed to have affirmed each representation and warranty
contained in this Agreement as if such representation and warranty were made as of such date, modified as necessary to relate to the Registration
Statement and the Prospectus as amended as of such date (except for any representation and warranty which is as of a specific date, in
which case such representation and warranty shall be affirmed as of such specific date). Any obligation of the Manager to use its commercially
reasonable efforts to sell the ADSs on behalf of the Company shall be subject to the continuing accuracy of the representations and warranties
of the Company herein, to the performance by the Company of its obligations hereunder and to the continuing satisfaction of the additional
conditions specified in Section 6 of this Agreement.
(ix) If
the Company shall declare or make any dividend or other distribution of its assets (or rights to acquire its assets) to holders of its
securities (including Ordinary Shares or ADSs), by way of return of capital or otherwise (including, without limitation, any distribution
of cash, shares or other securities, property or options by way of a dividend, spin off, reclassification, corporate rearrangement, scheme
of arrangement or other similar transaction) (a “Distribution” and the record date for the determination of shareholders
entitled to receive the Distribution, the “Record Date”), the Company hereby covenants that, in connection with any
sales of ADSs pursuant to a Sales Notice on the Record Date, the Company shall issue and deliver such ADSs to the Manager on the Record
Date and the Record Date shall be the Settlement Date and the Company shall cover any additional costs of the Manager in connection with
the delivery of ADSs on the Record Date.
(c) Term
Sales. If the Company wishes to sell the ADSs pursuant to this Agreement in a manner other than as set forth in Section 2(b) of this
Agreement (each, a “Placement”), the Company will notify the Manager of the proposed terms of such Placement. If the
Manager, acting as principal, wishes to accept such proposed terms (which it may decline to do for any reason in its sole discretion)
or, following discussions with the Company wishes to accept amended terms, the Manager and the Company will enter into a Terms Agreement
setting forth the terms of such Placement. The terms set forth in a Terms Agreement will not be binding on the Company or the Manager
unless and until the Company and the Manager have each executed such Terms Agreement accepting all of the terms of such Terms Agreement.
In the event of a conflict between the terms of this Agreement and the terms of a Terms Agreement, the terms of such Terms Agreement will
control. A Terms Agreement may also specify certain provisions relating to the reoffering of such ADSs by the Manager. The commitment
of the Manager to purchase the ADSs pursuant to any Terms Agreement shall be deemed to have been made on the basis of the representations
and warranties of the Company herein contained and shall be subject to the terms and conditions herein set forth. Each Terms Agreement
shall specify the number of the ADSs to be purchased by the Manager pursuant thereto, the price to be paid to the Company for such ADSs,
any provisions relating to rights of, and default by, underwriters acting together with the Manager in the reoffering of the ADSs, and
the time and date (each such time and date being referred to herein as a “Time of Delivery”) and place of delivery
of and payment for such ADSs. Such Terms Agreement shall also specify any requirements for opinions of counsel, accountants’ letters
and officers’ certificates pursuant to Section 6 of this Agreement and any other information or documents required by the Manager.
(d) Maximum
Number of ADSs. Under no circumstances shall the Company cause or request the offer or sale of any ADSs if, after giving effect to
the sale of such ADSs, the aggregate amount of ADSs sold pursuant to this Agreement would exceed the lesser of (A) together with all sales
of ADSs under this Agreement, the Maximum Amount, (B) the amount available for offer and sale under the currently effective Registration
Statement and (C) the amount authorized from time to time to be issued and sold under this Agreement by the Board, a duly authorized committee
thereof or a duly authorized executive committee, and notified to the Manager in writing. Under no circumstances shall the Company cause
or request the offer or sale of any ADSs pursuant to this Agreement at a price lower than the minimum price authorized from time to time
by the Board, a duly authorized committee thereof or a duly authorized executive officer, and notified to the Manager in writing. Further,
under no circumstances shall the Company cause or permit the aggregate offering amount of Ordinary Shares represented by ADSs sold pursuant
to this Agreement to exceed the Maximum Amount.
(e) Regulation
M Notice. Unless the exceptive provisions set forth in Rule 101(c)(1) of Regulation M under the Exchange Act are satisfied
with respect to the ADSs, the Company shall give the Manager at least one (1) Trading Day’s prior notice of its intent to sell any
ADSs in order to allow the Manager time to comply with Regulation M.
3. Representations
and Warranties. The Company represents and warrants to, and agrees with, the Manager at the Execution Time and on each such time that
the following representations and warranties are repeated or deemed to be made pursuant to this Agreement (except to the extent such representation
and warranty specifies a different time), as set forth below, except as set forth in the Registration Statement, the Prospectus or the
Incorporated Documents.
(a) Subsidiaries.
All of the direct and indirect subsidiaries (individually, a “Subsidiary”) of the Company are set forth on Exhibit
21.1 to the Company’s most recent Annual Report on Form 20-F filed with the Commission. The Company owns, directly or indirectly,
all of the share capital or other equity interests of each Subsidiary free and clear of any “Liens” (which for purposes
of this Agreement shall mean a lien, charge, security interest, encumbrance, right of first refusal, preemptive right or other restriction),
and all of the issued and outstanding share capital and other equity interests of each Subsidiary are validly issued and are fully paid,
non-assessable and free of preemptive and similar rights to subscribe for or purchase securities.
(b) Organization
and Qualification. The Company and each of the Subsidiaries is an entity duly incorporated or otherwise organized, validly existing
and, if applicable under the laws of the jurisdiction in which it was formed, in good standing under the laws of the jurisdiction of its
incorporation or organization, with the requisite power and authority to own and use its properties and assets and to carry on its business
as currently conducted, except where the failure of a Subsidiary to be in good standing would not have a Material Adverse Effect. Neither
the Company nor any Subsidiary is in violation nor in default of any of the provisions of its respective certificate or articles of incorporation
or memorandum and articles of association, as applicable, bylaws (if applicable) or other organizational or charter documents. Each of
the Company and the Subsidiaries is duly qualified to conduct business and is in good standing as a foreign corporation or other entity
in each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, except
where the failure to be so qualified or in good standing, as the case may be, could not have or reasonably be expected to result in: (i)
a material adverse effect on the legality, validity or enforceability of this Agreement, (ii) a material adverse effect on the results
of operations, assets, business, prospects or condition (financial or otherwise) of the Company and the Subsidiaries, taken as a whole,
from that set forth in the Registration Statement, the Base Prospectus, any Prospectus Supplement, the Prospectus or the Incorporated
Documents, or (iii) a material adverse effect on the Company’s ability to perform in any material respect on a timely basis its
obligations under this Agreement (any of (i), (ii) or (iii), a “Material Adverse Effect”) and no “Proceeding”
(which for purposes of this Agreement shall mean any action, claim, suit, investigation or proceeding (including, without limitation,
an informal investigation or partial proceeding, such as a deposition), whether commenced or threatened) has been instituted in any such
jurisdiction revoking, limiting or curtailing or seeking to revoke, limit or curtail such power and authority or qualification. Neither
the Company nor any of its Israeli subsidiaries is currently designated as a "breaching company" (within the meaning of the
Israeli Companies Law, 1999) (the "Companies Law") by the Registrar of Companies of the State of Israel, nor has a proceeding
been instituted in Israel by the Registrar of Companies of the State of Israel for the dissolution of the Company or any of its Israeli
subsidiaries.
(c) Authorization
and Enforcement. The Company has the requisite corporate power and authority to enter into and to consummate the transactions contemplated
by this Agreement and otherwise to carry out its obligations hereunder. The execution and delivery of this Agreement by the Company and
the consummation by it of the transactions contemplated hereby have been duly authorized by all necessary action on the part of the Company
and no further action is required by the Company, the Board or the Company’s shareholders in connection herewith other than in connection
with the Required Approvals. This Agreement has been duly executed and delivered by the Company and, when delivered in accordance with
the terms hereof, will constitute the valid and binding obligation of the Company enforceable against the Company in accordance with its
terms, except (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, moratorium and other
laws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by laws relating to the availability
of specific performance, injunctive relief or other equitable remedies and (iii) insofar as indemnification and contribution provisions
may be limited by applicable law.
(d) No
Conflicts. The execution, delivery and performance by the Company of this Agreement, the issuance of the Ordinary Shares and sale
of the ADSs representing such Ordinary Shares and the consummation by it of the transactions contemplated hereby do not and will not (i)
conflict with or violate any provision of the Company’s or any Subsidiary’s certificate or articles of incorporation or memorandum
and articles of association, bylaws or other organizational or charter documents, or (ii) conflict with, or constitute a default (or an
event that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any of the properties
or assets of the Company or any Subsidiary, or give to others any rights of termination, amendment, anti-dilution or similar adjustments,
acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit facility, debt or other instrument
(evidencing a Company or Subsidiary debt or otherwise) or other understanding to which the Company or any Subsidiary is a party or by
which any property or asset of the Company or any Subsidiary is bound or affected, or (iii) subject to the Required Approvals, conflict
with or result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any court or governmental
authority to which the Company or a Subsidiary is subject (including federal and state securities laws and regulations), or by which any
property or asset of the Company or a Subsidiary is bound or affected; except in the case of each of clauses (ii) and (iii), such as could
not, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect.
(e) Filings,
Consents and Approvals. The Company is not required to obtain any consent, waiver, authorization or order of, give any notice to,
or make any filing or registration with, any court or other federal, state, local, Israeli or other non-US governmental authority or other
“Person” (defined as an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture,
limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind, including
the Trading Market) in connection with the execution, delivery and performance by the Company of this Agreement, other than (i) the filings
required by this Agreement, (ii) the filing with the Commission of the Prospectus Supplement, (iii) the filing of application(s) to and
approval by the Trading Market for the listing of the ADSs for trading thereon in the time and manner required thereby, and (iv) such
filings as are required to be made under applicable U.S. state or non-U.S. securities laws and the rules and regulations of the Financial
Industry Regulatory Authority, Inc. (“FINRA”) or the laws of Israel (collectively, the “Required Approvals”).
(f) Issuance
of Ordinary Shares and ADSs. The Ordinary Shares represented by the ADSs are duly authorized and, when issued and paid for in accordance
with this Agreement, will be duly and validly issued, fully paid and nonassessable, free and clear of all Liens imposed by the Company.
The Company has reserved from its duly authorized shares capital a sufficient number of Ordinary Shares for the issuance of the ADSs issuable
pursuant to this Agreement. The offer and sale by the Company of the Ordinary Shares represented by ADSs and the offer and sale of the
ADSs has been registered under the Act and all of the ADSs are freely transferable and tradable by the purchasers thereof without restriction
(other than any restrictions arising solely from an act or omission of such a purchaser). The Ordinary Shares represented by ADSs are
being offered and sold pursuant to the Registration Statement and the issuance of the Ordinary Shares has been registered by the Company
under the Act. The Company and the Depositary have prepared and filed with the Commission registration statements relating to the ADSs
on Form F-6 (File No. 333-183741 and 333-249933) for the registration of the ADSs under the Act, which became effective on September 19,
2012 and November 6, 2020, respectively, and are effective as of the date hereof. The “Plan of Distribution” section
within the Registration Statement permits the offer and sale of the Ordinary Shares represented by ADSs as contemplated by this Agreement.
Upon receipt of the ADSs, the purchasers of such ADSs will have good and marketable title to such ADSs and the ADSs will be freely tradable
on the Trading Market.
(g) Capitalization.
The capitalization of the Company is as set forth in the SEC Reports. The Company has not issued any share capital, Ordinary Shares, including
Ordinary Shares represented by ADSs, since its most recently filed periodic report under the Exchange Act, other than pursuant to the
exercise of employee share options under the Company’s share option plans, the issuance of Ordinary Shares or ADSs to employees
pursuant to the Company’s employee share purchase plan and pursuant to the conversion and/or exercise of securities exercisable,
exchangeable or convertible into Ordinary Shares, including Ordinary Shares represented by ADSs, (“Ordinary Share Equivalents”)
outstanding as of the date of the most recently filed periodic report under the Exchange Act. No Person has any right of first refusal,
preemptive right, right of participation, or any similar right to participate in the transactions contemplated by this Agreement. Except
as set forth in the SEC Reports, there are no outstanding options, warrants, scrip rights to subscribe to, calls or commitments of any
character whatsoever relating to, or securities, rights or obligations convertible into or exercisable or exchangeable for, or giving
any Person any right to subscribe for or acquire, any Ordinary Shares, including Ordinary Shares represented by ADSs, or the share capital
of any Subsidiary, or contracts, commitments, understandings or arrangements by which the Company or any Subsidiary is or may become bound
to issue additional Ordinary Shares, including Ordinary Shares represented by ADSs, or Ordinary Share Equivalents or share capital of
any Subsidiary. The issuance and sale of the Ordinary Shares represented by the ADSs pursuant to this Agreement will not obligate the
Company or any Subsidiary to issue Ordinary Shares, including Ordinary Shares represented by ADSs, or other securities to any Person.
Except as set forth in the SEC Reports, there are no outstanding securities or instruments of the Company or any Subsidiary with any provision
that adjusts the exercise, conversion, exchange or reset price of such security or instrument upon an issuance of securities by the Company
or any Subsidiary. Except as set forth in the SEC Reports, there are no outstanding securities or instruments of the Company or any Subsidiary
that contain any redemption or similar provisions, and there are no contracts, commitments, understandings or arrangements by which the
Company or any Subsidiary is or may become bound to redeem a security of the Company or such Subsidiary. The Company does not have any
share appreciation rights or “phantom stock” plans or agreements or any similar plan or agreement. All of the outstanding
Ordinary Shares of the Company, including Ordinary Shares represented by ADSs, are duly authorized, validly issued, fully paid and nonassessable,
have been issued in compliance with all federal and state securities laws, and none of such outstanding shares was issued in violation
of any preemptive rights or similar rights to subscribe for or purchase securities. No further approval or authorization of any shareholder,
the Board or others is required for the issuance and sale of the Ordinary Shares represented by the ADSs pursuant to this Agreement. Except
as set forth in the SEC Reports, there are no shareholders agreements, voting agreements or other similar agreements with respect to the
Company’s Ordinary Shares, Ordinary Shares represented by ADSs or share capital to which the Company is a party or, to the knowledge
of the Company, between or among any of the Company’s shareholders.
(h) Registration
Statement. The Company meets the requirements for use of Form F-3 under the Act and has prepared and filed with the Commission
the Registration Statement, including a related Base Prospectus, for registration under the Act of the offering and sale of the Ordinary
Shares represented by the ADSs. The Registration Statement is effective and available for the offer and sale of the Ordinary Shares represented
by ADSs as of the date hereof. As filed, the Base Prospectus contains in all material respects all information required by the Act and
the rules thereunder, and, except to the extent the Manager shall agree in writing to a modification, shall be in all substantive respects
in the form furnished to the Manager prior to the Execution Time or prior to any such time this representation is repeated or deemed to
be made. The Registration Statement, at the Execution Time, each such time this representation is repeated or deemed to be made, and at
all times during which a prospectus is required by the Act to be delivered (whether physically or through compliance with Rule 172,
173 or any similar rule) in connection with any offer or sale of the Ordinary Shares represented by ADSs, meets the requirements set forth
in Rule 415(a)(1)(x). The initial Effective Date of the Registration Statement was not earlier than the date three years before the
Execution Time. The Company meets the transaction requirements as set forth in General Instruction I.B.1 of Form F-3 or, if applicable,
as set forth in General Instruction I.B.5 of Form F-3 with respect to the aggregate market value of securities being sold pursuant to
this offering and during the twelve (12) months prior to this offering.
(i) Accuracy
of Incorporated Documents. The Incorporated Documents, when they were filed with the Commission, conformed in all material respects
to the requirements of the Exchange Act and the rules thereunder, and none of the Incorporated Documents, when they were filed with the
Commission, contained any untrue statement of a material fact or omitted to state a material fact necessary to make the statements therein,
in light of the circumstances under which they were made not misleading; and any further documents so filed and incorporated by reference
in the Registration Statement, the Base Prospectus, the Prospectus Supplement or the Prospectus, when such documents are filed with the
Commission, will conform in all material respects to the requirements of the Exchange Act and the rules thereunder, as applicable, and
will not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in
light of the circumstances under which they were made, not misleading.
(j) Ineligible
Issuer. (i) At the earliest time after the filing of the Registration Statement that the Company or another offering participant
made a bona fide offer (within the meaning of Rule 164(h)(2)) of the ADSs and (ii) as of the Execution Time and on each such
time this representation is repeated or deemed to be made (with such date being used as the determination date for purposes of this clause (ii)),
the Company was not and is not an Ineligible Issuer (as defined in Rule 405), without taking account of any determination by the
Commission pursuant to Rule 405 that it is not necessary that the Company be considered an Ineligible Issuer.
(k) Free
Writing Prospectus. The Company is eligible to use Issuer Free Writing Prospectuses. Each Issuer Free Writing Prospectus does not
include any information the substance of which conflicts with the information contained in the Registration Statement, including any Incorporated
Documents and any prospectus supplement deemed to be a part thereof that has not been superseded or modified; and each Issuer Free Writing
Prospectus does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the
statements therein, in the light of the circumstances under which they were made, not misleading. The foregoing sentence does not apply
to statements in or omissions from any Issuer Free Writing Prospectus based upon and in conformity with written information furnished
to the Company by the Manager specifically for use therein. Any Issuer Free Writing Prospectus that the Company is required to file pursuant
to Rule 433(d) has been, or will be, filed with the Commission in accordance with the requirements of the Act and the rules thereunder.
Each Issuer Free Writing Prospectus that the Company has filed, or is required to file, pursuant to Rule 433(d) or that was prepared by
or behalf of or used by the Company complies or will comply in all material respects with the requirements of the Act and the rules thereunder.
The Company will not, without the prior consent of the Manager, prepare, use or refer to, any Issuer Free Writing Prospectuses.
(l) Proceedings
Related to Registration Statement. The Registration Statement is not the subject of a pending proceeding or examination under Section 8(d)
or 8(e) of the Act, and the Company is not the subject of a pending proceeding under Section 8A of the Act in connection with the
offering of the ADSs. The Company has not received any notice that the Commission has issued or intends to issue a stop-order with respect
to the Registration Statement or that the Commission otherwise has suspended or withdrawn the effectiveness of the Registration Statement,
either temporarily or permanently, or intends or has threatened in writing to do so.
(m) SEC
Reports. The Company has complied in all material respects with requirements to file all reports, schedules, forms, statements and
other documents required to be filed by the Company under the Act and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof,
for the one year preceding the date hereof (or such shorter period as the Company was required by law or regulation to file such material)
(the foregoing materials, including the exhibits thereto and documents incorporated by reference therein, together with the Prospectus
and the Prospectus Supplement, being collectively referred to herein as the “SEC Reports”) on a timely basis or has
received a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension. As
of their respective dates, the SEC Reports complied in all material respects with the requirements of the Act and the Exchange Act, as
applicable, and none of the SEC Reports, when filed, contained any untrue statement of a material fact or omitted to state a material
fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which
they were made, not misleading. The financial statements of the Company included in the SEC Reports comply in all material respects with
applicable accounting requirements and the rules and regulations of the Commission with respect thereto as in effect at the time of filing.
The interactive data in eXtensible Business Reporting Language included or incorporated by reference in the Registration Statement fairly
presents the information called for in all material respects and has been prepared in accordance with the Commission's rules and guidelines
applicable thereto. No other financial statements or supporting schedules are required to be included in the Registration Statement, the
Base Prospectus, any Prospectus Supplement or the Prospectus. Such financial statements have been prepared in accordance with United States
generally accepted accounting principles applied on a consistent basis during the periods involved (“GAAP”), except
as may be otherwise specified in such financial statements or the notes thereto and except that unaudited financial statements may not
contain all footnotes required by GAAP, and fairly present in all material respects the financial position of the Company and its consolidated
Subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the
case of unaudited statements, to normal, immaterial, year-end audit adjustments.
(n)
Statistical and Market-Related Data. All statistical, demographic and market-related data included in the Registration Statement
or the Prospectus are based on or derived from sources that the Company believes, after reasonable inquiry, to be reliable and accurate.
To the extent required, the Company has obtained the written consent for the use of such data from such sources.
(o) Material
Changes; Undisclosed Events, Liabilities or Developments. Since the date of the latest audited financial statements included within
the SEC Reports, except as specifically disclosed in a subsequent SEC Report filed prior to the date on which this representation is being
made, (i) there has been no event, occurrence or development that has had or that could reasonably be expected to result in a Material
Adverse Effect, (ii) the Company has not incurred any liabilities (contingent or otherwise) other than (A) trade payables and accrued
expenses incurred in the ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in
the Company’s financial statements pursuant to GAAP or disclosed in filings made with the Commission, (iii) the Company has not
altered its method of accounting, (iv) the Company has not declared or made any dividend or distribution of cash or other property to
its shareholders or purchased, redeemed or made any agreements to purchase or redeem any of its capital shares, (v) the Company has not
issued any equity securities to any officer, director or “Affiliate” (defined as any Person that, directly or indirectly
through one or more intermediaries, controls or is controlled by or is under common control with a Person, as such terms are used in and
construed under Rule 144 under the Act), except pursuant to existing Company share option plans, and (vi) no executive officer of the
Company or member of the Board has resigned from any position with the Company. The Company does not have pending before the Commission
any request for confidential treatment of information. Except for the issuance of the ADSs contemplated by this Agreement, no event, liability,
fact, circumstance, occurrence or development has occurred or exists or is reasonably expected to occur or exist with respect to the Company
or its Subsidiaries or their respective businesses, prospects, properties, operations, assets or financial condition that would be required
to be disclosed by the Company under applicable securities laws at the time this representation is made or deemed made that has not been
publicly disclosed at least one (1) Trading Day prior to the time that this representation is made.
(p) Litigation.
Except as set forth in the SEC Reports, there is no action, suit, inquiry, notice of violation, proceeding or investigation pending or,
to the knowledge of the Company, threatened against or affecting the Company, any Subsidiary or any of their respective properties before
or by any court, arbitrator, governmental or administrative agency or regulatory authority (federal, state, county, local, Israeli or
other non-U.S.) (collectively, an “Action”). None of the Actions set forth in the SEC Reports, (i) adversely affects
or challenges the legality, validity or enforceability of this Agreement or the ADSs or (ii) could, if there were an unfavorable decision,
have or reasonably be expected to result in a Material Adverse Effect. Neither the Company nor any Subsidiary, nor, to the knowledge of
the Company, any director or officer thereof, is or has been the subject of any Action involving a claim of violation of or liability
under federal or state securities laws or a claim of breach of fiduciary duty. There has not been, and to the knowledge of the Company,
there is not pending or contemplated, any investigation by the Commission involving the Company or, to the knowledge of the Company, any
current or former director or officer of the Company. The Commission has not issued any stop order or other order suspending the effectiveness
of any registration statement filed by the Company or any Subsidiary under the Exchange Act or the Act.
(q) Labor
Relations. No labor dispute exists or, to the knowledge of the Company, is imminent with respect to any of the employees of the Company,
which could reasonably be expected to result in a Material Adverse Effect. Except as set forth in the SEC Reports, none of the Company’s
or its Subsidiaries’ employees is a member of a union that relates to such employee’s relationship with the Company or such
Subsidiary, and neither the Company nor any of its Subsidiaries is a party to a collective bargaining agreement, and the Company and its
Subsidiaries believe that their relationships with their employees are good. To the knowledge of the Company, no executive officer of
the Company or any Subsidiary, is, or is now expected to be, in violation of any material term of any employment contract, confidentiality,
disclosure or proprietary information agreement or non-competition agreement, or any other contract or agreement or any restrictive covenant
in favor of any third party, and, to the knowledge of the Company, the continued employment of each such executive officer does not subject
the Company or any of its Subsidiaries to any liability with respect to any of the foregoing matters. The Company and its Subsidiaries
are in compliance in all material respects with all applicable U.S. federal, state, local, Israeli and other non-U.S. laws and regulations
relating to employment and employment practices, terms and conditions of employment and wages and hours, except where the failure to be
in compliance could not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.
(r) Compliance.
Neither the Company nor any Subsidiary: (i) is in default under or in violation of (and no event has occurred that has not been waived
that, with notice or lapse of time or both, would result in a default by the Company or any Subsidiary under), nor has the Company or
any Subsidiary received notice of a claim that it is in default under or that it is in violation of, any indenture, loan or credit agreement
or any other agreement or instrument to which it is a party or by which it or any of its properties is bound (whether or not such default
or violation has been waived), (ii) is in violation of any judgment, decree or order of any court, arbitrator or other governmental authority
or (iii) is or has been in violation of any statute, rule, ordinance or regulation of any governmental authority, including without limitation
all foreign, federal, state, local, Israeli and other non-U.S. laws relating to taxes, environmental protection, occupational health and
safety, product quality and safety and employment and labor matters, except in each case of (i), (ii) and (iii) as could not have or reasonably
be expected to result in a Material Adverse Effect.
(s) Environmental
Laws. The Company and its Subsidiaries (i) are in compliance in all material respects with all federal, state, local, Israeli or
other non-U.S. laws relating to pollution or protection of human health or the environment (including ambient air, surface water, groundwater,
land surface or subsurface strata), including laws relating to emissions, discharges, releases or threatened releases of chemicals, pollutants,
contaminants, or toxic or hazardous substances or wastes (collectively, “Hazardous Materials”) into the environment,
or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of Hazardous
Materials, as well as all authorizations, codes, decrees, demands, or demand letters, injunctions, judgments, licenses, notices or notice
letters, orders, permits, plans or regulations, issued, entered, promulgated or approved thereunder (“Environmental Laws”);
(ii) have received all permits licenses or other approvals required of them under applicable Environmental Laws to conduct their respective
businesses; and (iii) are in compliance in all material respects with all terms and conditions of any such permit, license or approval
where in each clause (i), (ii) and (iii), the failure to so comply could be reasonably expected to have, individually or in the aggregate,
a Material Adverse Effect.
(t) Regulatory
Permits. The Company and the Subsidiaries possess all certificates, authorizations and permits issued by the appropriate federal,
state, local, Israeli or other non-U.S. governmental or regulatory authorities necessary to conduct their respective businesses as described
in the SEC Reports, except where the failure to possess such permits could not reasonably be expected to result in a Material Adverse
Effect (“Material Permits”), and neither the Company nor any Subsidiary has received any notice of proceedings relating
to the revocation or modification of any Material Permit. The Company has not engaged in any form of solicitation, advertising or other
action constituting an offer or a sale under the Israeli Securities Law, 5728-1968 and the regulations promulgated thereunder in connection
with the transactions contemplated hereby, which would require the Company to publish a prospectus in the State of Israel under the laws
of the State of Israel.
(u) Title
to Assets. The Company and the Subsidiaries have good and marketable title in fee simple to all real property owned by them and good
and marketable title in all personal property owned by them that is material to the business of the Company and the Subsidiaries, in each
case free and clear of all Liens, except for (i) Liens as do not materially affect the value of such property and do not materially interfere
with the use made and proposed to be made of such property by the Company and the Subsidiaries and (ii) Liens for the payment of federal,
state, Israeli, non-U.S. or other taxes, for which appropriate reserves have been made therefor in accordance with GAAP and, the payment
of which is neither delinquent nor subject to penalties. Any real property and facilities held under lease by the Company and the Subsidiaries
are held by them under valid, subsisting and enforceable leases with which the Company and the Subsidiaries are in material compliance.
(v) Intellectual
Property. The Company and the Subsidiaries have, or have rights to use, all patents, patent applications, trademarks, trademark applications,
service marks, trade names, trade secrets, inventions, copyrights, licenses and other intellectual property rights and similar rights
necessary or required for use in connection with their respective businesses as described in the SEC Reports and which the failure to
so have could have a Material Adverse Effect (collectively, the “Intellectual Property Rights”). None of, and neither
the Company nor any Subsidiary has received a notice (written or otherwise) that any of, the Intellectual Property Rights has expired,
terminated or been abandoned, or is expected to expire or terminate or be abandoned, within two (2) years from the date of this Agreement,
except as would not be reasonably expected to have a Material Adverse Effect. Except as set forth in the SEC Reports, neither the Company
nor any Subsidiary has received, since the date of the latest audited financial statements included within the SEC Reports, a written
notice of a claim or otherwise has any knowledge that the Intellectual Property Rights violate or infringe upon the rights of any Person,
except as could not have or reasonably be expected to not have a Material Adverse Effect. To the knowledge of the Company, all such Intellectual
Property Rights are enforceable and there is no existing infringement by another Person of any of the Intellectual Property Rights. The
Company and its Subsidiaries have taken reasonable security measures to protect the secrecy, confidentiality and value of all of their
intellectual properties, except where failure to do so could not, individually or in the aggregate, reasonably be expected to have a Material
Adverse Effect. The Company has no knowledge of any facts that would preclude it from having valid license rights or clear title to the
Intellectual Property rights. The Company has no knowledge that it lacks or will be unable to obtain any rights or licenses to use all
Intellectual Property Rights that are necessary to conduct its business.
(w) Insurance.
The Company and the Subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in such
amounts as are prudent and customary in the businesses in which the Company and the Subsidiaries are engaged, including, but not limited
to, directors and officers insurance coverage. Neither the Company nor any Subsidiary has any reason to believe that it will not be able
to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may
be necessary to continue its business without a significant increase in cost.
(x) Affiliate
Transactions. Except as set forth in the SEC Reports, none of the officers or directors of the Company or any Subsidiary and, to the
knowledge of the Company, none of the employees of the Company or any Subsidiary is presently a party to any transaction with the Company
or any Subsidiary (other than for services as employees, officers and directors), including any contract, agreement or other arrangement
providing for the furnishing of services to or by, providing for rental of real or personal property to or from, providing for the borrowing
of money from or lending of money to or otherwise requiring payments to or from any officer, director or such employee or, to the knowledge
of the Company, any entity in which any officer, director, or any such employee has a substantial interest or is an officer, director,
trustee, shareholder, member or partner, in each case in excess of $120,000 other than for (i) payment of salary or consulting fees for
services rendered, (ii) reimbursement for expenses incurred on behalf of the Company and (iii) other employee benefits, including share
option agreements under any share option plan of the Company.
(y) Sarbanes
Oxley Compliance. The Company and the Subsidiaries are in compliance in all material respects with any and all applicable requirements
of the Sarbanes-Oxley Act of 2002, as amended, that are effective as of the date hereof, and any and all applicable rules and regulations
promulgated by the Commission thereunder that are effective as of the date hereof. The Company and the Subsidiaries maintain a system
of internal accounting controls sufficient to provide reasonable assurance that: (i) transactions are executed in accordance with management’s
general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity
with GAAP and to maintain asset accountability, (iii) access to assets is permitted only in accordance with management’s general
or specific authorization, and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals
and appropriate action is taken with respect to any differences. The Company and the Subsidiaries have established disclosure controls
and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Company and the Subsidiaries and designed such disclosure
controls and procedures to ensure that information required to be disclosed by the Company in the reports it files or submits under the
Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the Commission’s rules and forms.
The Company’s certifying officers have evaluated the effectiveness of the disclosure controls and procedures of the Company and
the Subsidiaries as of the end of the period covered by the most recently filed Form 20-F under the Exchange Act (such date, the “Evaluation
Date”), and the disclosure controls and procedures are effective in all material respects to perform the functions for which
they were established. The Company presented in its most recently filed periodic report under the Exchange Act the conclusions of the
certifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation
Date. Since the Evaluation Date, to the Company's knowledge, there have been no significant deficiencies or material weaknesses in the
Company's internal control over financial reporting (whether or not remediated) and no change in the Company's internal control over financial
reporting that has materially affected, or is reasonably likely to materially affect, the Company's internal control over financial reporting.
Since the Evaluation Date, there have been no changes in the internal control over financial reporting (as such term is defined in the
Exchange Act) of the Company and its Subsidiaries that have materially affected, or is reasonably likely to materially affect, the internal
control over financial reporting of the Company and its Subsidiaries.
(z) Certain
Fees. Other than payments to be made to the Manager, no brokerage or finder’s fees or commissions are or will be payable by
the Company or any Subsidiary to any broker, financial advisor or consultant, finder, placement agent, investment banker, bank or other
Person with respect to the transactions contemplated by this Agreement. The Manager shall have no obligation with respect to any fees
or with respect to any claims made by or on behalf of other Persons for fees of a type contemplated in this Section that may be due in
connection with the transactions contemplated by this Agreement.
(aa) No Other
Sales Agency Agreement. The Company has not entered into any other sales agency agreements or other similar arrangements with any
agent or any other representative in respect of at the market offerings of the Ordinary Shares or Ordinary Shares represented by ADSs.
(bb) Investment
Company. The Company is not, and is not an Affiliate of, and immediately after receipt of payment for the ADSs pursuant to this
Agreement, will not be or be an Affiliate of, an “investment company” within the meaning of the Investment Company Act of
1940, as amended. The Company shall conduct its business in a manner so that it and its Subsidiaries will not become an “investment
company” subject to registration under the Investment Company Act of 1940, as amended.
(cc) Listing
and Maintenance Requirements. The ADSs are listed on the Trading Market and the sale and delivery of the ADSs as contemplated by this
Agreement does not contravene the rules and regulations of the Trading Market. The Ordinary Shares or Ordinary Shares represented by ADSs
are registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and the Company has taken no action designed to, or which to its
knowledge is likely to have the effect of, terminating the registration of the Ordinary Shares or Ordinary Shares represented by ADSs
under the Exchange Act nor has the Company received any notification that the Commission is contemplating terminating such registration.
Except as set forth in the SEC Reports, the Company has not, in the 12 months preceding the date hereof, received notice from any Trading
Market on which the Ordinary Shares and/or ADSs are or have been listed or quoted to the effect that the Company is not in compliance
with the listing or maintenance requirements of such Trading Market. The Company is, and has no reason to believe that it will not in
the foreseeable future continue to be, in compliance with all such listing and maintenance requirements. The ADSs are currently eligible
for electronic transfer through the Depository Trust Company or another established clearing corporation and the Company is current in
payment of the fees to the Depositary and the Depository Trust Company (or such other established clearing corporation) in connection
with such electronic transfer.
(dd) [RESERVED]
(ee) Solvency.
Based on the consolidated financial condition of the Company as of the date hereof, (i) the fair saleable value of the Company’s
assets exceeds the amount that will be required to be paid on or in respect of the Company’s existing debts and other liabilities
(including known contingent liabilities) as they mature, (ii) the Company’s assets do not constitute unreasonably small capital
to carry on its business as now conducted and as proposed to be conducted including its capital needs taking into account the particular
capital requirements of the business conducted by the Company, consolidated and projected capital requirements and capital availability
thereof, and (iii) the current cash flow of the Company, together with the proceeds the Company would receive, were it to liquidate all
of its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in respect of
its liabilities when such amounts are required to be paid. The Company does not intend to incur debts beyond its ability to pay such debts
as they mature (taking into account the timing and amounts of cash to be payable on or in respect of its debt) within one year from the
date hereof. The Company has no knowledge of any facts or circumstances which lead it to believe that it will file for reorganization
or liquidation under the bankruptcy or reorganization laws of any jurisdiction within one year from the date hereof. The SEC Reports set
forth as of the date hereof all outstanding secured and unsecured Indebtedness of the Company or any Subsidiary, or for which the Company
or any Subsidiary has commitments. For the purposes of this Agreement, “Indebtedness” means (x) any liabilities for
borrowed money or amounts owed in excess of $100,000 (other than trade accounts payable incurred in the ordinary course of business),
(y) all guaranties, endorsements and other contingent obligations in respect of indebtedness of others, whether or not the same are or
should be reflected in the Company’s consolidated balance sheet (or the notes thereto), except guaranties by endorsement of negotiable
instruments for deposit or collection or similar transactions in the ordinary course of business; and (z) the present value of any lease
payments in excess of $100,000 due under leases required to be capitalized in accordance with GAAP. Except as set forth in the SEC Reports,
neither the Company nor any Subsidiary is in default with respect to any Indebtedness.
(ff) Tax Status.
Except for matters that would not, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect,
the Company and its Subsidiaries each (i) has made or filed, or has received timely extension thereof, all United States federal, state,
local, Israeli and other non-U.S. income and all foreign income and franchise tax returns, reports and declarations required by any jurisdiction
to which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in amount, shown or determined
to be due on such returns, reports and declarations and (iii) has set aside on its books provision reasonably adequate for the payment
of all material taxes for periods subsequent to the periods to which such returns, reports or declarations apply. There are no unpaid
taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company or of any
Subsidiary know of no basis for any such claim.
(gg) Foreign
Corrupt Practices. Neither the Company nor any Subsidiary, nor to the knowledge of the Company or any Subsidiary, any agent or other
person acting on behalf of the Company or any Subsidiary, has (i) directly or indirectly, used any funds for unlawful contributions, gifts,
entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any unlawful payment to foreign
or domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii)
failed to disclose fully any contribution made by the Company or any Subsidiary (or made by any person acting on its behalf of which the
Company is aware) which is in violation of law, or (iv) violated in any material respect any provision of the Foreign Corrupt Practices
Act of 1977, as amended, or any applicable law or regulation implementing the OECD Convention on Combating Bribery of Foreign Public Officials
in International Business Transactions, or committed an offence under the Bribery Act 2010 of the United Kingdom or any other applicable
anti-bribery or any other applicable anti-corruption law, including, without limitation, Section 291A of the Israel Penal Law 5737-1977
and the rules and regulations thereunder.
(hh) Accountants.
The Company's accounting firm is set forth in the SEC Reports. To the knowledge and belief of the Company, such accounting firm (i) is
a registered public accounting firm as required by the Exchange Act and the rules of the Public Company Accounting Oversight Board ("PCAOB"),
(ii) has expressed its opinion with respect to the financial statements included in the Company's Annual Report for the fiscal year ended
December 31, 2023, (iii) is in compliance with the applicable requirements relating to the qualification of accountants under Rule 2-01
of Regulation S-X under the Act and (iv) a registered public accounting firm as defined by PCAOB whose registration has not been suspended
or revoked and who has not requested such registration to be withdrawn.
(ii) Regulation
M Compliance. The Company has not, and to its knowledge no one acting on its behalf has, (i) taken, directly or indirectly,
any action designed to cause or to result in the stabilization or manipulation of the price of any security of the Company to facilitate
the sale or resale of any of the Ordinary Shares or ADSs, (ii) sold, bid for, purchased, or, paid any compensation for soliciting purchases
of, any of the Ordinary Shares or ADSs, or (iii) paid or agreed to pay to any Person any compensation for soliciting another to purchase
any other securities of the Company, other than, in the case of clauses (ii) and (iii), compensation paid to the Manager in connection
with the sale of the ADSs hereunder.
(jj) FDA.
As to each product subject to the jurisdiction of the U.S. Food and Drug Administration (“FDA”) under the Federal Food,
Drug and Cosmetic Act, as amended, and the regulations thereunder (“FDCA”) that is manufactured, packaged, labeled,
tested, distributed, sold, and/or marketed by the Company or any of its Subsidiaries (each such product, a “Pharmaceutical Product”),
such Pharmaceutical Product is being manufactured, packaged, labeled, tested, distributed, sold and/or marketed by the Company in compliance
with all applicable requirements under FDCA and similar laws, rules and regulations relating to registration, investigational use, premarket
clearance, licensure, or application approval, good manufacturing practices, good laboratory practices, good clinical practices, product
listing, quotas, labeling, advertising, record keeping and filing of reports, except where the failure to be in compliance would not have
a Material Adverse Effect. There is no pending, completed or, to the Company's knowledge, threatened, action (including any lawsuit, arbitration,
or legal or administrative or regulatory proceeding, charge, complaint, or investigation) against the Company or any of its Subsidiaries,
and none of the Company or any of its Subsidiaries has received any notice, warning letter or other communication from the FDA or any
other governmental entity, which (i) contests the premarket clearance, licensure, registration, or approval of, the uses of, the distribution
of, the manufacturing or packaging of, the testing of, the sale of, or the labeling and promotion of any Pharmaceutical Product, (ii)
withdraws its approval of, requests the recall, suspension, or seizure of, or withdraws or orders the withdrawal of advertising or sales
promotional materials relating to, any Pharmaceutical Product, (iii) imposes a clinical hold on any clinical investigation by the Company
or any of its Subsidiaries, (iv) enjoins production at any facility of the Company or any of its Subsidiaries, (v) enters or proposes
to enter into a consent decree of permanent injunction with the Company or any of its Subsidiaries, or (vi) otherwise alleges any violation
of any laws, rules or regulations by the Company or any of its Subsidiaries, and which, either individually or in the aggregate, would
have a Material Adverse Effect. The properties, business and operations of the Company have been and are being conducted in all material
respects in accordance with all applicable laws, rules and regulations of the FDA. The Company has not been informed by the FDA
that the FDA will prohibit the marketing, sale, license or use in the United States of any product proposed to be developed, produced
or marketed by the Company nor has the FDA expressed any concern as to approving or clearing for marketing any product being developed
or proposed to be developed by the Company.
(kk) Share
Option Plans. With respect to the share options (the "Share Options") granted pursuant to the share-based compensation
plans of the Company and its subsidiaries (the "Company Share Plans"), (i) each Share Option purported to be issued under
Section 102 of the Israeli Tax Ordinance - (New Version) 1961 qualifies for treatment under that section and for treatment under either
the capital gains track or the employment income track, as was indicated with respect to each such Share Option at the date that such
Share Option was granted, except as would not reasonably be expected to result in a Material Adverse Effect, (ii) each Share Option intended
to qualify as an "incentive stock option" under Section 422 of the Code (as defined below) so qualifies, except as would not
reasonably be expected to result in a Material Adverse Effect, (iii) each grant of a Share Option was duly authorized no later than the
date on which the grant of such Share Option was by its terms to be effective (the "Grant Date") by all necessary corporate
action, including, as applicable, approval by the Board (or a duly constituted and authorized committee thereof) and any required shareholder
approval, and the award agreement governing such grant (if any) was duly executed and delivered by each party thereto, (iv) each such
grant was made in accordance with the terms of the Company Share Plans and all other applicable laws and regulatory rules or requirements,
and (v) each such grant was properly accounted for in accordance with GAAP in the financial statements (including the related notes) of
the Company included in the Registration Statement and Prospectus.
(ll) Cybersecurity.
(i)(x) There has been no security breach or other compromise of or relating to any of the Company’s or any Subsidiary’s information
technology and computer systems, networks, hardware, software, data (including the data of its respective customers, employees, suppliers,
vendors and any third party data maintained by or on behalf of it), equipment or technology (collectively, “IT Systems and Data”),
except as would not, individually or in the aggregate, have a Material Adverse Effect, and (y) the Company and the Subsidiaries have not
been notified of, and has no knowledge of any event or condition that would reasonably be expected to result in, any material security
breach or other compromise to its IT Systems and Data; (ii) the Company and the Subsidiaries are presently in compliance in all material
respects with all applicable laws or statutes (including, but not limited to, the European Union General Data Protection Regulation and
the Israeli Privacy Protection Regulations, Information, Security, 2017) and all applicable judgments, orders, rules and regulations of
any court or arbitrator or governmental or regulatory authority, internal policies and contractual obligations relating to the privacy
and security of IT Systems and Data and to the protection of such IT Systems and Data from unauthorized use, access, misappropriation
or modification, except as would not, individually or in the aggregate, have a Material Adverse Effect; (iii) the Company and the
Subsidiaries have implemented and maintained commercially reasonable safeguards to maintain and protect its material confidential information
and the integrity, continuous operation, redundancy and security of all IT Systems and Data; and (iv) the Company and the Subsidiaries
have implemented backup and disaster recovery technology consistent with industry standards and practices.
(mm) Compliance
with Data Privacy Laws. (i) The Company and the Subsidiaries are, and at all times during the past three years were, in compliance
with all applicable data privacy and security laws and regulations, including, as applicable, the European Union General Data Protection
Regulation (“GDPR”) (EU 2016/679) and Israeli Privacy Protection Regulations, Information, Security, 2017 (collectively,
“Privacy Laws”); (ii) the Company and the Subsidiaries have in place, comply with, and take appropriate steps
reasonably designed to ensure compliance with their policies and procedures relating to data privacy and security and the collection,
storage, use, disclosure, handling and analysis of Personal Data (the “Policies”); (iii) the Company provides
accurate notice of its applicable Policies to its customers, employees, third party vendors and representatives as required by Privacy
Laws; and (iv) applicable Policies provide accurate and sufficient notice of the Company’s then-current privacy practices relating
to its subject matter, and do not contain any material omissions of the Company’s then-current privacy practices, as required by
Privacy Laws. “Personal Data” means (i) a natural person’s name, street address, telephone number,
email address, photograph, social security number, bank information, or customer or account number; (ii) any information which would
qualify as “personally identifying information” under the Federal Trade Commission Act, as amended; (iii) “personal
data” as defined by GDPR; and (iv) any other piece of information that allows the identification of such natural person, or
his or her family, or permits the collection or analysis of any identifiable data related to an identified person’s health or sexual
orientation. (i) None of such disclosures made or contained in any of the Policies have been inaccurate, misleading, or deceptive
in violation of any Privacy Laws and (ii) the execution, delivery and performance of this Agreement will not result in a breach of
any Privacy Laws or Policies. Neither the Company nor the Subsidiaries, (i) has, to the knowledge of the Company, received
written notice of any actual or potential liability of the Company or the Subsidiaries under, or actual or potential violation by the
Company or the Subsidiaries of, any of the Privacy Laws; (ii) is currently conducting or paying for, in whole or in part, any investigation,
remediation or other corrective action pursuant to any regulatory request or demand pursuant to any Privacy Law; or (iii) is a party
to any order, decree, or agreement by or with any court or arbitrator or governmental or regulatory authority that imposed any obligation
or liability under any Privacy Law.
(nn) Office
of Foreign Assets Control. Neither the Company nor any of its Subsidiaries, nor to the knowledge of the Company, any of the directors,
officers or employees of the Company or its Subsidiaries, is an individual or entity that is, or is owned or controlled by an individual
or entity that is: (i) the subject of any sanctions administered or enforced by the U.S. Department of Treasury’s Office of
Foreign Assets Control, the United Nations Security Council, the European Union, His Majesty’s Treasury, or other relevant sanctions
authority, including by virtue of similar laws or rules of the State of Israel (collectively, “Sanctions”), nor (ii) located,
organized or resident in a country or territory that is the subject of Sanctions. Neither the Company nor any of its Subsidiaries will,
directly or indirectly, use the proceeds of the transactions contemplated hereby, or lend, contribute or otherwise make available such
proceeds to any Subsidiary, joint venture partner or other Person: (i) to fund or facilitate any activities or business of or with
any Person or in any country or territory that, at the time of such funding or facilitation, is the subject of Sanctions or (ii) in
any other manner that will result in a violation of Sanctions by any Person (including any Person participating in the transactions contemplated
hereby, whether as underwriter, advisor, investor or otherwise). For the past five years, neither the Company nor any of its Subsidiaries
has knowingly engaged in, and is not now knowingly engaged in, any dealings or transactions with any Person, or in any country or territory,
that at the time of the dealing or transaction is or was the subject of Sanctions.
(oo) U.S.
Real Property Holding Corporation. The Company is not and has never been a U.S. real property holding corporation within the meaning
of Section 897 of the Internal Revenue Code of 1986, as amended, and the Company shall so certify upon the Manager’s request.
(pp) Bank
Holding Company Act. Neither the Company nor any of its Subsidiaries or Affiliates is subject to the Bank Holding Company Act of 1956,
as amended (the “BHCA”) and to regulation by the Board of Governors of the Federal Reserve System (the “Federal
Reserve”). Neither the Company nor any of its Subsidiaries or Affiliates owns or controls, directly or indirectly, five percent
(5%) or more of the outstanding shares of any class of voting securities or twenty-five percent (25%) or more of the total equity of a
bank or any entity that is subject to the BHCA and to regulation by the Federal Reserve. Neither the Company nor any of its Subsidiaries
or Affiliates exercises a controlling influence over the management or policies of a bank or any entity that is subject to the BHCA and
to regulation by the Federal Reserve.
(qq) Money
Laundering. The operations of the Company and its Subsidiaries are and have been conducted at all times in compliance with applicable
financial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the money
laundering statutes of all jurisdictions where the Company or any of its Subsidiaries conducts business including the Israel Prohibition
on Money Laundering Law, 5760-2000, Israel Prohibition on Money Laundering Order, 5761-2001 and the Israel Prohibition on Terrorist Financing
Law, 5765-2005, any applicable money laundering statutes and applicable rules and regulations thereunder (collectively, the “Money
Laundering Laws”), and no Action or Proceeding by or before any court or governmental agency, authority or body or any arbitrator
involving the Company or any Subsidiary with respect to the Money Laundering Laws is pending or, to the knowledge of the Company or any
Subsidiary, threatened.
(rr) FINRA
Member Shareholders. There are no affiliations with any FINRA member firm among the Company’s officers, directors or, to the
knowledge of the Company, any five percent (5%) or greater shareholder of the Company, except as set forth in the Registration Statement,
the Base Prospectus, any Prospectus Supplement or the Prospectus.
(ss) ERISA
Compliance. Except as otherwise disclosed in the Registration Statement and the Prospectus, the Company and its Subsidiaries and any
"employee benefit plan" (as defined under the Employee Retirement Income Security Act of 1974, as amended, and the regulations
and published interpretations thereunder (collectively, "ERISA")) established or maintained by the Company, its Subsidiaries
or their "ERISA Affiliates" (as defined below) are in compliance in all material respects with ERISA. "ERISA Affiliate"
means, with respect to the Company or any of its Subsidiaries, any member of any group of organizations described in Sections 414(b),
(c), (m) or (o) of the Internal Revenue Code of 1986, as amended, and the regulations and published interpretations thereunder (the "Code")
of which the Company or such Subsidiary is a member. No "reportable event" (as defined under ERISA) has occurred or is reasonably
expected to occur with respect to any "employee benefit plan" established or maintained by the Company, its Subsidiaries or
any of their ERISA Affiliates. No "employee benefit plan" established or maintained by the Company, its Subsidiaries or any
of their ERISA Affiliates, if such "employee benefit plan" were terminated, would have any "amount of unfunded benefit
liabilities" (as defined under ERISA). Neither the Company, its Subsidiaries nor any of their ERISA Affiliates has incurred or reasonably
expects to incur any liability under (i) Title IV of ERISA with respect to termination of, or withdrawal from, any "employee benefit
plan" or (ii) Sections 412, 4971, 4975 or 4980B of the Code. Each "employee benefit plan" established or maintained by
the Company, its subsidiaries or any of their ERISA Affiliates that is intended to be qualified under Section 401(a) of the Code is so
qualified and nothing has occurred, whether by action or failure to act, which would cause the loss of such qualification.
(tt) Authorization
of the Deposit Agreement. The Deposit Agreement has been duly authorized, executed and delivered by the Company and constitutes a
legal, valid and binding agreement of the Company, enforceable against the Company in accordance with its terms, except as enforcement
thereof may be limited by bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and similar laws of general applicability
relating to or affecting creditors' rights and to general principles of equity; upon due issuance by the Depositary of ADSs against the
deposit of the Ordinary Shares in respect thereof in accordance with the Deposit Agreement, such ADSs sold hereunder will be duly and
validly issued and the owners and holders thereof will be entitled to the rights specified therein and in the Deposit Agreement; and the
Deposit Agreement and the ADSs conform in all material respects to the descriptions thereof contained in the Prospectus.
(uu) Forward-Looking
Statements. Each financial or operational projection or other "forward-looking statement" (as defined by Section 27A of
the Act or Section 21E of the Exchange Act) contained in the Registration Statement or the Prospectus (i) was so included by the Company
in good faith and with reasonable basis after due consideration by the Company of the underlying assumptions, estimates and other applicable
facts and circumstances and (ii) as required, is accompanied by meaningful cautionary statements identifying those factors that could
cause actual results to differ materially from those in such forward-looking statement. No such statement was made that was false or misleading
with the knowledge of a director or senior manager of the Company that it was false or misleading.
(vv) Israeli
Tax Benefits. (i) The Company is in compliance with all conditions and requirements stipulated by the instruments of approval and
tax ruling (the "Ruling") granted to it with respect to "Benefited Enterprise" ("Tax Incentive Program")
status of the Company and/or any of its facilities as well as with respect to the other tax benefits received by the Company as set forth
under the caption "Israeli Tax Considerations and Government Programs" in the Registration Statement and the Prospectus and
by Israeli laws and regulations relating to its Tax Incentive Program and the aforementioned other tax benefits received by the Company;
(ii) all information supplied by the Company with respect to applications relating to its Tax Incentive Program (including in connection
with the Ruling) was true, correct and complete when supplied to the appropriate authorities; and (iii) the Company has not received any
notice of any proceeding or investigation relating to revocation or modification of any of its current or past Tax Incentive Program granted
with respect to the Company and/or any of its facilities, in each case except for any failure to comply, inaccuracy or notice (as appropriate)
that would not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect.
(ww) No Immunity.
Neither the Company nor any of its Subsidiaries or their properties or assets has immunity under the State of Israel, U.S. federal or
New York state law from any legal action, suit or proceeding, from the giving of any relief in any such legal action, suit or proceeding,
from set-off or counterclaim, from the jurisdiction of the State of Israel, U.S. federal or New York state court, from service of process,
attachment upon or prior to judgment, or attachment in aid of execution of judgment, or from execution of a judgment, or other legal process
or proceeding for the giving of any relief or for the enforcement of a judgment, in any such court with respect to their respective obligations,
liabilities or any other matter under or arising out of or in connection herewith; and, to the extent that the Company or any of its subsidiaries
or any of its properties, assets or revenues may have or may hereafter become entitled to any such right of immunity in any such court
in which proceedings arising out of, or relating to the transactions contemplated by this Agreement, may at any time be commenced, the
Company has, pursuant to this Agreement, waived, and it will waive, or will cause its Subsidiaries to waive, such right to the extent
permitted by law.
(xx) Enforcement
of Foreign Judgments. Any final judgment for a fixed or determined sum of money rendered by any U.S. federal or New York state court
located in the State of New York having jurisdiction under its own laws in respect of any suit, action or proceeding against the Company
based upon this Agreement are enforceable against the Company by the courts of the State of Israel, without reconsideration or reexamination
of the merits, subject to the limitations described in the Registration Statement and the Prospectus under "Enforceability of Civil
Liabilities."
(yy) Valid
Choice of Law. The choice of laws of the State of New York as the governing law of this Agreement is a valid choice of law under the
laws of the State of Israel and would be enforceable by the courts of the State of Israel, subject to the restrictions described under
the caption "Enforceability of Civil Liabilities" in the Registration Statement and the Prospectus. The Company has the power
to submit, and pursuant to Section 16 of this Agreement, has legally, validly, effectively and irrevocably submitted, to the personal
jurisdiction of each New York state and United States federal court sitting in the City of New York and has validly and irrevocably waived
any objection to the laying of venue of any suit, action or proceeding brought in such court.
(zz) Indemnification
and Contribution. The indemnification and contribution provisions set forth in Section 7 hereof do not contravene Israeli law or public
policy.
(aaa) Dividends.
Except as disclosed in the Registration Statement and the Prospectus, (i) no approvals are currently required under the laws of the State
of Israel in order for the Company to pay dividends or other distributions declared by the Company to the holders of Shares assuming the
Company has sufficient profits for distribution under the Companies Law, and (ii) under current laws and regulations of the State of Israel,
any amount payable with respect to the Shares upon liquidation of the Company or upon redemption thereof and dividends and other distributions
declared and payable on the share capital of the Company may be paid by the Company in United States dollars or euros and freely transferred
out of the State of Israel, subject to payment of applicable withholding taxes or an exemption therefrom.
(bbb) Legal
Action. A holder of the ADSs and the Manager are each entitled to sue as plaintiff in the court of the jurisdiction of formation and
domicile of the Company for the enforcement of their respective rights under this Agreement and the ADSs and such access to such courts
will not be subject to any conditions which are not applicable to residents of such jurisdiction or a company incorporated in such jurisdiction
except that plaintiffs not residing in the State of Israel may be required to guarantee payment of a possible order for payment of costs
or damages at the request of the defendant.
(ccc) Foreign
Issuer. The Company is a "foreign private issuer" as defined in Rule 405 under the Securities Act.
(ddd) Emerging
Growth Company. The Company has been and is an "emerging growth company," as defined in Section 2(a) of the Securities Act
(an "Emerging Growth Company").
4. Agreements.
The Company agrees with the Manager that:
(a) Right
to Review Amendments and Supplements to Registration Statement and Prospectus. During any period when the delivery of a prospectus
relating to the ADSs is required (including in circumstances where such requirement may be satisfied pursuant to Rule 172, 173 or
any similar rule) to be delivered under the Act in connection with the offering or the sale of ADSs, the Company will not file any amendment
to the Registration Statement or supplement (including any Prospectus Supplement, but excluding any annual report of the Company filed
pursuant to Section 13(a) or 15(d) of the Exchange Act) to the Base Prospectus unless the Company has furnished to the Manager a copy
for its review prior to filing and will not file any such proposed amendment or supplement to which the Manager reasonably objects (provided,
however, that the Company will have no obligation to provide the Manager any advance copy of such filing or to provide the Manager an
opportunity to object to such filing if the filing does not name the Manager and does not relate to the transactions under this Agreement).
The Company has properly completed the Prospectus, in a form approved by the Manager, and filed such Prospectus, as amended at the Execution
Time, with the Commission pursuant to the applicable paragraph of Rule 424(b) by the Execution Time and will cause any supplement
to the Prospectus to be properly completed, in a form approved by the Manager, and will file such supplement with the Commission pursuant
to the applicable paragraph of Rule 424(b) within the time period prescribed thereby and will provide evidence reasonably satisfactory
to the Manager of such timely filing. The Company will promptly advise the Manager (i) when the Prospectus, and any supplement thereto,
shall have been filed (if required) with the Commission pursuant to Rule 424(b), (ii) when, during any period when the delivery
of a prospectus (whether physically or through compliance with Rule 172, 173 or any similar rule) is required under the Act in connection
with the offering or sale of the Ordinary Shares or ADSs, any amendment to the Registration Statement shall have been filed or become
effective (other than any annual report of the Company filed pursuant to Section 13(a) or 15(d) of the Exchange Act), (iii) of any
request by the Commission or its staff for any amendment of the Registration Statement, or for any supplement to the Prospectus or for
any additional information, (iv) of the issuance by the Commission of any stop order suspending the effectiveness of the Registration
Statement or of any notice objecting to its use or the institution or threatening of any proceeding for that purpose and (v) of the
receipt by the Company of any notification with respect to the suspension of the qualification of the Ordinary Shares or ADSs for sale
in any jurisdiction or the institution or threatening of any proceeding for such purpose. The Company will use its commercially reasonable
best efforts to prevent the issuance of any such stop order or the occurrence of any such suspension or objection to the use of the Registration
Statement and, upon such issuance, occurrence or notice of objection, to obtain as soon as possible the withdrawal of such stop order
or relief from such occurrence or objection, including, if necessary, by filing an amendment to the Registration Statement or a new registration
statement and using its commercially reasonable efforts to have such amendment or new registration statement declared effective as soon
as practicable.
(b) Subsequent
Events. If, at any time on or after an Applicable Time but prior to the related Settlement Date, any event occurs as a result of which
the Registration Statement or Prospectus would include any untrue statement of a material fact or omit to state any material fact necessary
to make the statements therein in the light of the circumstances under which they were made or the circumstances then prevailing not misleading,
the Company will (i) notify promptly the Manager so that any use of the Registration Statement or Prospectus may cease until such
are amended or supplemented; (ii) amend or supplement the Registration Statement or Prospectus to correct such statement or omission;
and (iii) supply any such amendment or supplement to the Manager in such quantities as the Manager may reasonably request.
(c) Notification
of Subsequent Filings. During any period when the delivery of a prospectus relating to the ADSs is required (including in circumstances
where such requirement may be satisfied pursuant to Rule 172, 173 or any similar rule) to be delivered under the Act, any event occurs
as a result of which the Prospectus as then supplemented would include any untrue statement of a material fact or omit to state any material
fact necessary to make the statements therein in the light of the circumstances under which they were made not misleading, or if it shall
be necessary to amend the Registration Statement, file a new registration statement or supplement the Prospectus to comply with the Act
or the Exchange Act or the respective rules thereunder, including in connection with use or delivery of the Prospectus, the Company promptly
will (i) notify the Manager of any such event (provided that such notification to the Manager shall not be required if a Sales Notice
has neither been delivered nor is pending at the time of such event, but such notification shall be required at least three (3) Trading
Days prior to delivery by the Company of any Sales Notice to the Manager to sell ADSs hereunder), (ii) subject to Section 4(a), prepare
and file with the Commission an amendment or supplement or new registration statement which will correct such statement or omission or
effect such compliance, (iii) use its commercially reasonable efforts to have any amendment to the Registration Statement or new
registration statement declared effective as soon as practicable in order to avoid any disruption in use of the Prospectus and (iv) supply
any supplemented Prospectus to the Manager in such quantities as the Manager may reasonably request.
(d) Earnings
Statements. As soon as practicable, the Company will make generally available to its security holders and to the Manager an earnings
statement or statements of the Company and its Subsidiaries which will satisfy the provisions of Section 11(a) of the Act and Rule 158.
For the avoidance of doubt, the Company’s compliance with the reporting requirements of the Exchange Act shall be deemed to satisfy
the requirements of this Section 4(d).
(e) Delivery
of Registration Statement. Upon the request of the Manager, the Company will furnish to the Manager and counsel for the Manager, without
charge, signed copies of the Registration Statement (including exhibits thereto) and, so long as delivery of a prospectus by the Manager
or dealer may be required by the Act (including in circumstances where such requirement may be satisfied pursuant to Rule 172, 173
or any similar rule), as many copies of the Prospectus and each Issuer Free Writing Prospectus and any supplement thereto as the Manager
may reasonably request. The Company will pay the expenses of printing or other production of all documents relating to the offering.
(f) Qualification
of ADSs. The Company will arrange, if necessary, for the qualification of the ADSs or Ordinary Shares for sale under the laws of such
jurisdictions as the Manager may designate and will maintain such qualifications in effect so long as required for the distribution of
the ADSs; provided that in no event shall the Company be obligated to qualify to do business in any jurisdiction where it is not now so
qualified or to take any action that would subject it to service of process in suits, other than those arising out of the offering or
sale of the ADSs, in any jurisdiction where it is not now so subject.
(g) Free
Writing Prospectus. The Company agrees that, unless it has or shall have obtained the prior written consent of the Manager, and the
Manager agrees with the Company that, unless it has or shall have obtained, as the case may be, the prior written consent of the Company,
it has not made and will not make any offer relating to the ADSs that would constitute an Issuer Free Writing Prospectus or that would
otherwise constitute a “free writing prospectus” (as defined in Rule 405) required to be filed by the Company with the
Commission or retained by the Company under Rule 433. Any such free writing prospectus consented to by the Manager or the Company
is hereinafter referred to as a “Permitted Free Writing Prospectus.” The Company agrees that (i) it has treated
and will treat, as the case may be, each Permitted Free Writing Prospectus as an Issuer Free Writing Prospectus and (ii) it has complied
and will comply, as the case may be, with the requirements of Rules 164 and 433 applicable to any Permitted Free Writing Prospectus,
including in respect of timely filing with the Commission, legending and record keeping.
(h) Subsequent
Equity Issuances. The Company shall not deliver any Sales Notice hereunder (and any Sales Notice previously delivered shall not apply
during such two (2) Trading Days) for at least two (2) Trading Days prior to any date on which the Company or any Subsidiary offers, sells,
issues, contracts to sell, contracts to issue or otherwise disposes of, directly or indirectly, any other Ordinary Shares, ADSs or any
Ordinary Share Equivalents (other than the ADSs issuable pursuant to this Agreement), subject to Manager’s right to waive this obligation,
provided that, without compliance with the foregoing obligation, the Company may issue (i) Ordinary Shares or ADSs or Ordinary Share Equivalents
pursuant to any employee equity plan, share ownership plan or dividend reinvestment plan of the Company in effect from time to time and
(iii) Ordinary Shares or ADSs issuable upon the conversion or exercise of Ordinary Share Equivalents outstanding from time to time, and
(iii) ADSs, Ordinary Shares or any Ordinary Share Equivalents in a privately negotiated transactions to vendors, service providers, strategic
partners or potential strategic partners, provided that such issuances are not made for capital raising purposes and are conducted in
a manner so as not to be integrated with the offering of ADSs hereby for purposes of Regulation M and to not constitute a distribution
for purposes of Regulation M.
(i) Market
Manipulation. Until the termination of this Agreement, the Company will not take, directly or indirectly, any action designed to or
that would constitute or that might reasonably be expected to cause or result in, under the Exchange Act or otherwise, stabilization or
manipulation in violation of the Act, Exchange Act or the rules and regulations thereunder of the price of any security of the Company
to facilitate the sale or resale of the ADSs or otherwise violate any provision of Regulation M under the Exchange Act.
(j) Notification
of Incorrect Certificate. The Company will, at any time during the term of this Agreement, as supplemented from time to time, advise
the Manager immediately after it shall have received notice or obtained knowledge thereof, of any information or fact that would alter
or affect any opinion, certificate, letter and other document provided to the Manager pursuant to Section 6 herein.
(k) Certification
of Accuracy of Disclosure. Upon commencement of the offering of the ADSs under this Agreement (and upon the recommencement of the
offering of the ADSs under this Agreement following the termination of a suspension of sales hereunder lasting more than 30 Trading Days),
and each time that (i) a new Registration Statement is filed and declared effective, (ii) the Registration Statement or Prospectus shall
be amended or supplemented, other than by means of Incorporated Documents, (iii) the Company files its Annual Report on Form 20-F under
the Exchange Act, (iv) the Company files a report on Form 6-K under the Exchange Act containing financial information for a six month
period, or the Company voluntarily files a report on Form 6-K under the Exchange Act containing financial information for a three month
period or a nine month period (v) the Company files a report on Form 6-K containing amended financial information (other than information
that is furnished and not filed), if the Manager reasonably determines that the information in such Form 6-K is material, or (vi) the
ADSs are delivered to the Manager as principal at the Time of Delivery pursuant to a Terms Agreement (such commencement or recommencement
date and each such date referred to in (i), (ii), (iii), (iv), (v) and (vi) above, a “Representation Date”), unless
waived by the Manager, the Company shall furnish or cause to be furnished to the Manager forthwith a certificate dated and delivered within
five (5) Trading Days of the Representation Date, in form reasonably satisfactory to the Manager to the effect that the statements contained
in the certificate referred to in Section 6 of this Agreement which were last furnished to the Manager are true and correct at the Representation
Date, as though made at and as of such date (except that such statements shall be deemed to relate to the Registration Statement and the
Prospectus as amended and supplemented to such date) or, in lieu of such certificate, a certificate of the same tenor as the certificate
referred to in said Section 6, modified as necessary to relate to the Registration Statement and the Prospectus as amended and supplemented
to the date of delivery of such certificate. Notwithstanding the foregoing, the requirement to furnish or cause to be furnished a certificate
under this Section 4(k) shall be waived for any Representation Date occurring at a time at which no instruction to the Manager to sell
ADSs pursuant to this Agreement has been delivered by the Company or is pending. Notwithstanding the foregoing, if the Company subsequently
decides to sell ADSs following any Representation Date when the Company relied on such waiver and did not provide the Manager a certificate
pursuant to this Section 4(k), then before the Company instructs the Manager to sell ADSs pursuant to this Agreement, the Company shall
provide the Manager such certificate to the extent required under this Section 4(k) and not previously delivered.
(l) Bring
Down Opinions; Negative Assurance. Within five (5) Trading Days of each Representation Date, unless waived by the Manager, the Company
shall furnish or cause to be furnished forthwith to the Manager and to counsel to the Manager a written opinion of Company Israeli Counsel
and a written opinion of Company U.S. Counsel addressed to the Manager and dated and delivered within five (5) Trading Days of such Representation
Date, in form and substance reasonably satisfactory to the Manager, including a negative assurance representation from Company U.S. Counsel.
The requirement to furnish or cause to be furnished opinions (but not with respect to a negative assurance representation from US Counsel)
under this Section 4(l) shall be waived for any Representation Date other than a new Registration Statement is filed and declared effective
or a Representation Date on which a material amendment to the Registration Statement or Prospectus is made or the Company files its Annual
Report on Form 20-F or a material amendment thereto under the Exchange Act, unless the Manager reasonably requests such deliverable required
by this Section 4(l) in connection with a Representation Date, upon which request such deliverable shall be deliverable hereunder. Notwithstanding
the foregoing, the requirement to furnish or cause to be furnished an opinion or negative assurance representation under this Section
4(l) shall be waived for any Representation Date occurring at a time at which no instruction to the Manager to sell ADSs pursuant to this
Agreement has been delivered by the Company or is pending. Notwithstanding the foregoing, if the Company subsequently decides to sell
ADSs following any Representation Date when the Company relied on such waiver and did not provide the Manager such opinions or negative
assurance representation pursuant to this Section 4(l), then before the Company instructs the Manager to sell ADSs pursuant to this Agreement,
the Company shall provide the Manager with such opinions or negative assurance representation to the extent required under this Section
4(l) and not previously delivered.
(m) Auditor
Bring Down “Comfort” Letter. Within five (5) Trading Days of each Representation Date, unless waived by the Manager, the
Company shall cause (1) the Company’s auditors (the “Accountants”), or other independent accountants satisfactory
to the Manager forthwith to furnish the Manager a letter, and (2) the Chief Financial Officer of the Company forthwith to furnish
the Manager a certificate, in each case dated and delivered within five (5) Trading Days of such Representation Date, in form satisfactory
to the Manager, of the same tenor as the letters and certificate referred to in Section 6 of this Agreement but modified to relate to
the Registration Statement and the Prospectus, as amended and supplemented to the date of such letters and certificate. The requirement
to furnish or cause to be furnished a “comfort” letter under this Section 4(m) shall be waived for any Representation Date
other than a Representation Date on which a new Registration Statement is filed and declared effective or a material amendment to the
Registration Statement or Prospectus is made or the Company files its Annual Report on Form 20-F or a material amendment thereto under
the Exchange Act, unless the Manager reasonably requests the deliverables required by this Section 4(m) in connection with a Representation
Date, upon which request such deliverable shall be deliverable hereunder. Notwithstanding the foregoing, the requirement to deliver or
cause to be delivered one or more letters or certificates under this Section 4(m) shall, at the request of the Company, be waived for
any Representation Date occurring at a time at which no instruction to the Manager to sell ADSs pursuant to this Agreement has been delivered
by the Company or is pending. Notwithstanding the foregoing, if the Company subsequently decides to sell ADSs following any Representation
Date when the Company relied on such waiver and did not provide the Manager with a letter or certificate pursuant to this Section 4(m),
then before the Company instructs the Manager to sell ADSs pursuant to this Agreement, the Company shall provide the Manager such letter
or certificate to the extent required under this Section 4(m) and not previously delivered.
(n) Due
Diligence Session. Upon commencement of the offering of the ADSs under this Agreement (and upon the recommencement of the offering
of the ADSs under this Agreement following the termination of a suspension of sales hereunder lasting more than thirty (30) Trading Days),
and within five (5) Trading Days at each Representation Date, the Company will conduct a due diligence session, in form and substance,
reasonably satisfactory to the Manager, which shall include representatives of management and Accountants. The Company shall cooperate
timely with any reasonable due diligence request from or review conducted by the Manager or its agents from time to time in connection
with the transactions contemplated by this Agreement, including, without limitation, providing information and available documents and
access to appropriate corporate officers and the Company’s agents during regular business hours, and timely furnishing or causing
to be furnished such certificates, letters and opinions from the Company, its officers and its agents, as the Manager may reasonably request.
The Company shall reimburse the Manager for Manager’s counsel’s fees in each such due diligence update session, up to a maximum
of $2,500 per update in connection with Section 4(k)(iv) and $5,000 per update in connection with Section 4(k)(iii), plus any incidental
expense incurred by the Manager in connection therewith.
(o) Acknowledgment
of Trading. The Company consents to the Manager trading in the Ordinary Shares and ADSs, subject to applicable law, for the Manager’s
own account and for the account of its clients at the same time as sales of the ADSs occur pursuant to this Agreement or pursuant to a
Terms Agreement.
(p) Disclosure
of ADSs Sold. The Company will disclose in its Annual Reports on Form 20-F and on Form 6-K when disclosing interim financial
reports, as applicable, the number of ADSs sold through the Manager under this Agreement, the Net Proceeds to the Company and the compensation
paid by the Company with respect to sales of ADSs pursuant to this Agreement during the relevant quarter; and, if required by any subsequent
change in Commission policy or request, more frequently by means of a Report of Foreign Private Issuer on Form 6-K or a further Prospectus
Supplement.
(q) Rescission
Right. If to the knowledge of the Company, the conditions set forth in Section 6 shall not have been satisfied as of the applicable
Settlement Date, the Company will offer to any Person who has agreed to purchase ADSs from the Company as the result of an offer to purchase
solicited by the Manager the right to refuse to purchase and pay for such ADSs.
(r) Bring
Down of Representations and Warranties. Each acceptance by the Company of an offer to purchase the ADSs hereunder, and each execution
and delivery by the Company of a Terms Agreement, shall be deemed to be an affirmation to the Manager that the representations and warranties
of the Company contained in or made pursuant to this Agreement are true and correct as of the date of such acceptance or of such Terms
Agreement as though made at and as of such date, and an undertaking that such representations and warranties will be true and correct
as of the Settlement Date for the ADSs relating to such acceptance or as of the Time of Delivery relating to such sale, as the case may
be, as though made at and as of such date (except that such representations and warranties shall be deemed to relate to the Registration
Statement and the Prospectus as amended and supplemented relating to such ADSs).
(s) Reservation
of Ordinary Shares. The Company shall ensure that there are at all times sufficient authorized share capital for issuance of Ordinary
Shares to provide for the issuance, free of any preemptive rights, out of its authorized but unissued Ordinary Shares or its Ordinary
Shares held in treasury, of a sufficient number of Ordinary Shares authorized for issuance by the Board to be represented by ADSs to be
delivered pursuant to the terms of this Agreement. The Company will use its commercially reasonable efforts to cause the Ordinary Shares
represented by ADSs issuable pursuant to this Agreement to be listed for trading on the Trading Market and to maintain such listing.
(t) Obligation
Under Exchange Act. During any period when the delivery of a prospectus relating to the Ordinary Shares represented by the ADSs is
required (including in circumstances where such requirement may be satisfied pursuant to Rule 172, 173 or any similar rule) to be
delivered under the Act, the Company will file all documents required to be filed with the Commission pursuant to the Exchange Act within
the time periods required by the Exchange Act and the regulations thereunder.
(u) DTC
Facility. The Company shall cooperate with the Manager and use its reasonable efforts to permit the ADSs to be eligible for clearance
and settlement through the facilities of DTC.
(v) Use
of Proceeds. The Company will apply the Net Proceeds from the sale of the ADSs in the manner set forth in the Prospectus.
(w) Filing
of Prospectus Supplement. If any sales are made pursuant to this Agreement which are not made in “at the market” offerings
as defined in Rule 415, including, without limitation, any Placement pursuant to a Terms Agreement, the Company shall file a Prospectus
Supplement describing the terms of such transaction, the amount of ADSs sold, the price thereof, the Manager’s compensation, and
such other information as may be required pursuant to Rule 424 and Rule 430B, as applicable, within the time required by Rule 424.
(x) Additional
Registration Statement. To the extent that the Registration Statement is not available for the sales of the Ordinary Shares represented
by ADSs as contemplated by this Agreement, the Company shall file a new registration statement with respect to any additional Ordinary
Shares and/or ADSs necessary to complete such sales of the Ordinary Shares represented by ADSs and, upon the filing of such registration
statement, shall cause such registration statement to become effective as promptly as practicable. After the effectiveness of any such
registration statement, all references to “Registration Statement” included in this Agreement shall be deemed to include
such new registration statement, including all documents incorporated by reference therein pursuant to Item 12 of Form F-3, and all
references to “Base Prospectus” included in this Agreement shall be deemed to include the final form of prospectus,
including all documents incorporated therein by reference, included in any such registration statement at the time such registration statement
became effective.
(y) Emerging
Growth Company; Foreign Private Issuer. The Company will promptly notify the Manager if the Company ceases to be an Emerging Growth
Company or a Foreign Private Issuer at any time prior to the later of (i) the sale of all ADSs provided for in the Prospectus and (ii)
the termination of this Agreement in accordance with Section 8 herein.
5. Payment
of Expenses. The Company agrees to pay the costs and expenses incident to the performance of its obligations under this Agreement,
whether or not the transactions contemplated hereby are consummated, including without limitation: (i) the preparation, printing
or reproduction and filing with the Commission of the Registration Statement (including financial statements and exhibits thereto), the
Prospectus and each Issuer Free Writing Prospectus, and each amendment or supplement to any of them; (ii) the printing (or reproduction)
and delivery (including postage, air freight charges and charges for counting and packaging) of such copies of the Registration Statement,
the Prospectus, and each Issuer Free Writing Prospectus, and all amendments or supplements to any of them, as may, in each case, be reasonably
requested for use in connection with the offering and sale of the ADSs; (iii) the preparation, printing, authentication, issuance
and delivery of certificates for the ADSs, including any stamp or transfer taxes in connection with the original issuance and sale of
the ADSs; (iv) the printing (or reproduction) and delivery of this Agreement, any blue sky memorandum and all other agreements or
documents printed (or reproduced) and delivered in connection with the offering of the ADSs; (v) the registration of the Ordinary
Shares and ADSs under the Exchange Act, if applicable, and the listing of the ADSs on the Trading Market; (vi) any registration or
qualification of the Ordinary Shares and Ordinary Shares represented by ADSs for offer and sale under the securities or blue sky laws
of the several states (including filing fees and the reasonable fees and expenses of counsel for the Manager relating to such registration
and qualification); (vii) the transportation and other expenses incurred by or on behalf of Company representatives in connection
with presentations to prospective purchasers of the ADSs; (viii) the fees and expenses of the Company’s accountants and the
fees and expenses of counsel (including local and special counsel) for the Company; (ix) the filing fee under FINRA Rule 5110; (x) the
reasonable fees and expenses of the Manager’s counsel, not to exceed $50,000 (excluding any periodic due diligence fees provided
for under Section 4(n)), which shall be paid upon the Execution Time; (xi) fees charged to the Manager by the Depositary in connection
with the issuance and sale of the ADSs and/or Ordinary Shares, which shall be paid promptly upon request by the Manager; and (xii) all
other costs and expenses incident to the performance by the Company of its obligations hereunder.
6. Conditions
to the Obligations of the Manager. The obligations of the Manager under this Agreement, any Terms Agreement and any Sales Notice shall
be subject to (i) the accuracy of the representations and warranties on the part of the Company contained herein as of the Execution
Time, each Representation Date, and as of each Applicable Time, Settlement Date and Time of Delivery, (ii) the performance by the
Company of its obligations hereunder and (iii) the following additional conditions:
(a) Filing
of Prospectus Supplement. The Prospectus, and any supplement thereto, required by Rule 424 to be filed with the Commission have
been filed in the manner and within the time period required by Rule 424(b) with respect to any sale of Ordinary Shares represented
by ADSs; each Prospectus Supplement shall have been filed in the manner required by Rule 424(b) within the time period required hereunder
and under the Act; any other material required to be filed by the Company pursuant to Rule 433(d) under the Act, shall have been
filed with the Commission within the applicable time periods prescribed for such filings by Rule 433; and no stop order suspending
the effectiveness of the Registration Statement or any notice objecting to its use shall have been issued and, to the knowledge of the
Company, no proceedings for that purpose shall have been instituted or threatened.
(b) Delivery
of Opinions. The Company shall have caused the (i) Company U.S. Counsel to furnish to the Manager its opinion and negative assurance
statement, (ii) Company Israeli Counsel to furnish to the Manager its opinion, and (iii) Depositary Counsel to furnish to the Manager
its opinion, in each case, dated as of such date and addressed to the Manager in form and substance acceptable to the Manager.
(c) Delivery
of Officer’s Certificate. The Company shall have furnished or caused to be furnished to the Manager a certificate of the Company
signed by the Chief Executive Officer or the President and the principal financial or accounting officer of the Company, dated as of such
date, to the effect that the signers of such certificate have carefully examined the Registration Statement, the Prospectus, any Prospectus
Supplement and any documents incorporated by reference therein and any supplements or amendments thereto and this Agreement and that:
(i) the
representations and warranties of the Company in this Agreement are true and correct in all material respects on and as of such date with
the same effect as if made on such date and the Company has complied in all material respects with all the agreements and satisfied all
the conditions on its part to be performed or satisfied at or prior to such date;
(ii) no
stop order suspending the effectiveness of the Registration Statement or any notice objecting to its use has been issued and, to the Company’s
knowledge, no proceedings for that purpose have been instituted or threatened; and
(iii) since
the date of the most recent financial statements included in the Registration Statement, the Prospectus and the Incorporated Documents,
there has been no Material Adverse Effect on the condition (financial or otherwise), results of operations, earnings, business or properties
of the Company and its subsidiaries, taken as a whole, whether or not arising from transactions in the ordinary course of business, except
as set forth in or contemplated in the Registration Statement and the Prospectus.
(d) Delivery
of Accountants’ “Comfort” Letter. The Company shall have requested and caused the Accountants to have furnished
to the Manager letters (which may refer to letters previously delivered to the Manager), dated as of such date, in form and substance
satisfactory to the Manager, confirming that they are independent accountants within the meaning of the Act and the Exchange Act and the
respective applicable rules and regulations adopted by the Commission thereunder and that they have performed a review of any unaudited
interim financial information of the Company included or incorporated by reference in the Registration Statement and the Prospectus and
provide customary “comfort” as to such review in form and substance satisfactory to the Manager.
(e) No
Material Adverse Event. Since the respective dates as of which information is disclosed in the Registration Statement, the Prospectus
and the Incorporated Documents, except as otherwise stated therein, there shall not have been (i) any change or decrease in previously
reported results specified in the letter or letters referred to in paragraph (d) of this Section 6 or (ii) any change, or any
development involving a prospective change, in or affecting the condition (financial or otherwise), earnings, business or properties of
the Company and its subsidiaries taken as a whole, whether or not arising from transactions in the ordinary course of business, except
as set forth in or contemplated in the Registration Statement, the Prospectus and the Incorporated Documents (exclusive of any amendment
or supplement thereto) the effect of which, in any case referred to in clause (i) or (ii) above, is, in the sole judgment of
the Manager, so material and adverse as to make it impractical or inadvisable to proceed with the offering or delivery of the ADSs as
contemplated by the Registration Statement (exclusive of any amendment thereof), the Incorporated Documents and the Prospectus (exclusive
of any amendment or supplement thereto).
(f) Payment
of All Fees. The Company shall have paid the required Commission filing fees relating to the Ordinary Shares and ADSs within the time
period required by Rule 456(b)(1)(i) of the Act without regard to the proviso therein and otherwise in accordance with Rules 456(b)
and 457(r) of the Act and, if applicable, shall have updated the “Calculation of Registration Fee” table in accordance with
Rule 456(b)(1)(ii) either in a post-effective amendment to the Registration Statement or on the cover page of a prospectus filed
pursuant to Rule 424(b).
(g) No
FINRA Objections. FINRA shall not have raised any objection with respect to the fairness and reasonableness of the terms and arrangements
under this Agreement.
(h) ADSs
Listed on Trading Market. The ADSs shall have been listed and admitted and authorized for trading on the Trading Market, and satisfactory
evidence of such actions shall have been provided to the Manager.
(i) Deposit
Agreement. The Deposit Agreement shall be in full force and effect, and the Company shall have taken all action necessary to permit
the deposit of the Ordinary Shares with the Depositary and the issuance of the ADSs in accordance with the Deposit Agreement.
(j) Other
Assurances. Prior to each Settlement Date and Time of Delivery, as applicable, the Company shall have furnished to the Manager such
further information, certificates and documents as the Manager may reasonably request.
If any of the conditions specified
in this Section 6 shall not have been fulfilled when and as provided in this Agreement, or if any of the opinions and certificates mentioned
above or elsewhere in this Agreement shall not be reasonably satisfactory in form and substance to the Manager and counsel for the Manager,
this Agreement and all obligations of the Manager hereunder may be canceled at, or at any time prior to, any Settlement Date or Time of
Delivery, as applicable, by the Manager. Notice of such cancellation shall be given to the Company in writing or by telephone and confirmed
in writing by email.
The documents required to
be delivered by this Section 6 shall be delivered to the office of Ellenoff Grossman & Schole LLP, counsel for the Manager, at 1345
Avenue of the Americas, New York, New York 10105, email: capmkts@egsllp.com, on each such date as provided in this Agreement.
7. Indemnification
and Contribution.
(a) Indemnification
by Company. The Company agrees to indemnify and hold harmless the Manager, the directors, officers, employees and agents of the Manager
and each person who controls the Manager within the meaning of either the Act or the Exchange Act against any and all losses, claims,
damages or liabilities, joint or several, to which they or any of them may become subject under the Act, the Exchange Act or other Federal
or state statutory law or regulation, at common law or otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of a material fact contained in the Registration
Statement for the registration of the Ordinary Shares and ADSs as originally filed or in any amendment thereof, or in the Base Prospectus,
any Prospectus Supplement, the Prospectus, any Issuer Free Writing Prospectus, or in any amendment thereof or supplement thereto, or arise
out of or are based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary
to make the statements therein not misleading or arise out of or are based upon any Proceeding, commenced or threatened (whether or not
the Manager is a target of or party to such Proceeding) or result from or relate to any breach of any of the representations, warranties,
covenants or agreements made by the Company in this Agreement, and agrees to reimburse each such indemnified party for any legal or other
expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action;
provided, however, that the Company will not be liable in any such case to the extent that any such loss, claim, damage
or liability arises out of or is based upon any such untrue statement or alleged untrue statement or omission or alleged omission made
therein in reliance upon and in conformity with written information furnished to the Company by the Manager specifically for inclusion
therein. This indemnity agreement will be in addition to any liability that the Company may otherwise have.
(b) Indemnification
by Manager. The Manager agrees to indemnify and hold harmless the Company, each of its directors, each of its officers who signs the
Registration Statement, and each person who controls the Company within the meaning of either the Act or the Exchange Act, to the same
extent as the foregoing indemnity from the Company to the Manager, but only with reference to written information relating to the Manager
furnished to the Company by the Manager specifically for inclusion in the documents referred to in the foregoing indemnity; provided,
however, that in no case shall the Manager be responsible for any amount in excess of the Broker Fee applicable to the ADSs and
paid hereunder. This indemnity agreement will be in addition to any liability which the Manager may otherwise have.
(c) Indemnification
Procedures. Promptly after receipt by an indemnified party under this Section 7 of notice of the commencement of any action,
such indemnified party will, if a claim in respect thereof is to be made against the indemnifying party under this Section 7, notify
the indemnifying party in writing of the commencement thereof; but the failure so to notify the indemnifying party (i) will not relieve
it from liability under paragraph (a) or (b) above unless and to the extent it did not otherwise learn of such action and such
failure results in the forfeiture by the indemnifying party of substantial rights and defenses and (ii) will not, in any event, relieve
the indemnifying party from any obligations to any indemnified party other than the indemnification obligation provided in paragraph (a)
or (b) above. The indemnifying party shall be entitled to appoint counsel of the indemnifying party’s choice at the indemnifying
party’s expense to represent the indemnified party in any action for which indemnification is sought (in which case the indemnifying
party shall not thereafter be responsible for the fees and expenses of any separate counsel retained by the indemnified party or parties
except as set forth below); provided, however, that such counsel shall be reasonably satisfactory to the indemnified party.
Notwithstanding the indemnifying party’s election to appoint counsel to represent the indemnified party in an action, the indemnified
party shall have the right to employ separate counsel (including local counsel), and the indemnifying party shall bear the documented
and reasonable fees, costs and expenses of such separate counsel if (i) the use of counsel chosen by the indemnifying party to represent
the indemnified party would present such counsel with a conflict of interest, (ii) the actual or potential defendants in, or targets
of, any such action include both the indemnified party and the indemnifying party and the indemnified party shall have reasonably concluded
that there may be legal defenses available to it and/or other indemnified parties which are different from or additional to those available
to the indemnifying party, (iii) the indemnifying party shall not have employed counsel reasonably satisfactory to the indemnified
party to represent the indemnified party within a reasonable time after notice of the institution of such action or (iv) the indemnifying
party shall authorize the indemnified party to employ separate counsel at the expense of the indemnifying party. An indemnifying party
will not, without the prior written consent of the indemnified parties, settle or compromise or consent to the entry of any judgment with
respect to any pending or threatened claim, action, suit or proceeding in respect of which indemnification or contribution may be sought
hereunder (whether or not the indemnified parties are actual or potential parties to such claim or action) unless such settlement, compromise
or consent includes an unconditional release of each indemnified party from all liability arising out of such claim, action, suit or proceeding.
(d) Contribution.
In the event that the indemnity provided in paragraph (a), (b) or (c) of this Section 7 is unavailable to or insufficient
to hold harmless an indemnified party for any reason, the Company and the Manager agree to contribute to the aggregate losses, claims,
damages and liabilities (including legal or other expenses reasonably incurred in connection with investigating or defending the same)
(collectively “Losses”) to which the Company and the Manager may be subject in such proportion as is appropriate to
reflect the relative benefits received by the Company on the one hand and by the Manager on the other from the offering of the ADSs; provided,
however, that in no case shall the Manager be responsible for any amount in excess of the Broker Fee applicable to the ADSs and
paid hereunder. If the allocation provided by the immediately preceding sentence is unavailable for any reason, the Company and the Manager
severally shall contribute in such proportion as is appropriate to reflect not only such relative benefits but also the relative fault
of the Company on the one hand and of the Manager on the other in connection with the statements or omissions which resulted in such Losses
as well as any other relevant equitable considerations. Benefits received by the Company shall be deemed to be equal to the total net
proceeds from the offering (before deducting expenses) received by it, and benefits received by the Manager shall be deemed to be equal
to the Broker Fee applicable to the ADSs and paid hereunder as determined by this Agreement. Relative fault shall be determined by reference
to, among other things, whether any untrue or any alleged untrue statement of a material fact or the omission or alleged omission to state
a material fact relates to information provided by the Company on the one hand or the Manager on the other, the intent of the parties
and their relative knowledge, access to information and opportunity to correct or prevent such untrue statement or omission. The Company
and the Manager agree that it would not be just and equitable if contribution were determined by pro rata allocation or any other method
of allocation which does not take account of the equitable considerations referred to above. Notwithstanding the provisions of this paragraph (d),
no person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Act) shall be entitled to contribution
from any person who was not guilty of such fraudulent misrepresentation. For purposes of this Section 7, each person who controls
the Manager within the meaning of either the Act or the Exchange Act and each director, officer, employee and agent of the Manager shall
have the same rights to contribution as the Manager, and each person who controls the Company within the meaning of either the Act or
the Exchange Act, each officer of the Company who shall have signed the Registration Statement and each director of the Company shall
have the same rights to contribution as the Company, subject in each case to the applicable terms and conditions of this paragraph (d).
8. Termination.
(a) The
Company shall have the right, by giving written notice as hereinafter specified, to terminate this Agreement in its sole discretion at
any time upon five (5) Business Days’ prior written notice. Any such termination shall be without liability of any party to any
other party except that (i) with respect to any pending sale, through the Manager for the Company, the obligations of the Company,
including in respect of compensation of the Manager, shall remain in full force and effect notwithstanding the termination and (ii) the
provisions of Sections 5, 6, 7, 8, 9, 10, 12, the second sentence of 13, 14 and 15 of this Agreement shall remain in full force and
effect notwithstanding such termination.
(b) The
Manager shall have the right, by giving written notice as hereinafter specified, to terminate the provisions of this Agreement relating
to the solicitation of offers to purchase the ADSs in its sole discretion at any time. Any such termination shall be without liability
of any party to any other party except that the provisions of Sections 5, 6, 7, 8, 9, 10, 12, the second sentence of 13, 14 and 15
of this Agreement shall remain in full force and effect notwithstanding such termination.
(c) This
Agreement shall remain in full force and effect until such date that this Agreement is terminated pursuant to Sections 8(a) or (b) above
or otherwise by mutual agreement of the parties, provided that any such termination by mutual agreement shall in all cases be deemed to
provide that Sections 5, 6, 7, 8, 9, 10, 12, the second sentence of 13, 14 and 15 of this Agreement shall remain in full force and
effect.
(d) Any
termination of this Agreement shall be effective on the date specified in such notice of termination, provided that such termination shall
not be effective until the close of business on the date of receipt of such notice by the Manager or the Company, as the case may be.
If such termination shall occur prior to the Settlement Date or Time of Delivery for any sale of the ADSs, such sale of the ADSs shall
settle in accordance with the provisions of Section 2(b) of this Agreement.
(e) In
the case of any purchase of ADSs by the Manager pursuant to a Terms Agreement, the obligations of the Manager pursuant to such Terms Agreement
shall be subject to termination, in the absolute discretion of the Manager, by prompt oral notice given to the Company prior to the Time
of Delivery relating to such ADSs, if any, and confirmed promptly by electronic mail, if since the time of execution of the Terms Agreement
and prior to such delivery and payment, (i) trading in the ADSs shall have been suspended by the Commission or the Trading Market
or trading in securities generally on the Trading Market shall have been suspended or limited or minimum prices shall have been established
on such exchange, (ii) a banking moratorium shall have been declared either by Federal or New York State authorities or (iii) there
shall have occurred any outbreak or escalation of hostilities, declaration by the United States of a national emergency or war, or other
calamity or crisis the effect of which on financial markets is such as to make it, in the sole judgment of the Manager, impractical or
inadvisable to proceed with the offering or delivery of the ADSs as contemplated by the Prospectus (exclusive of any amendment or supplement
thereto).
9. Representations
and Indemnities to Survive. The respective agreements, representations, warranties, indemnities and other statements of the Company
or its officers and of the Manager set forth in or made pursuant to this Agreement will remain in full force and effect, regardless of
any investigation made by the Manager or the Company or any of the officers, directors, employees, agents or controlling persons referred
to in Section 7, and will survive delivery of and payment for the ADSs.
10. Notices.
All communications hereunder will be in writing and effective only on receipt, and will be mailed, delivered, or e-mailed to the addresses
of the Company and the Manager, respectively, set forth on the signature page hereto.
11. Successors.
This Agreement will inure to the benefit of and be binding upon the parties hereto and their respective successors and the officers, directors,
employees, agents and controlling persons referred to in Section 7, and no other person will have any right or obligation hereunder.
12. No
Fiduciary Duty. The Company hereby acknowledges that (a) the purchase and sale of the ADSs pursuant to this Agreement is an arm’s-length
commercial transaction between the Company, on the one hand, and the Manager and any affiliate through which it may be acting, on the
other, (b) the Manager is acting solely as sales agent and/or principal in connection with the purchase and sale of the Company’s
securities and not as a fiduciary of the Company and (c) the Company’s engagement of the Manager in connection with the offering
and the process leading up to the offering is as independent contractors and not in any other capacity. Furthermore, the Company agrees
that it is solely responsible for making its own judgments in connection with the offering (irrespective of whether the Manager has advised
or is currently advising the Company on related or other matters). The Company agrees that it will not claim that the Manager has rendered
advisory services of any nature or respect, or owe an agency, fiduciary or similar duty to the Company, in connection with such transaction
or the process leading thereto.
13. Integration.
This Agreement and any Terms Agreement supersede all prior agreements and understandings (whether written or oral) between the Company
and the Manager with respect to the subject matter hereof. Notwithstanding anything herein to the contrary, the letter agreement, dated
July 2, 2024, by and between the Company and the Manager shall continue to be effective and the terms therein shall continue to survive
and be enforceable by the Manager in accordance with its terms, provided that, in the event of a conflict between the terms of the letter
agreement and this Agreement, the terms of this Agreement shall prevail.
14. Amendments;
Waivers. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed, in
the case of an amendment, by the Company and the Manager. No waiver of any default with respect to any provision, condition or requirement
of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other
provision, condition or requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any manner
impair the exercise of any such right.
15. Applicable
Law. This Agreement and any Terms Agreement will be governed by and construed in accordance with the laws of the State of New York
applicable to contracts made and to be performed within the State of New York. Each of the Company and the Manager: (i) agrees that
any legal suit, action or proceeding arising out of or relating to this Agreement shall be instituted exclusively in New York Supreme
Court, County of New York, or in the United States District Court for the Southern District of New York, (ii) waives any objection which
it may have or hereafter to the venue of any such suit, action or proceeding, and (iii) irrevocably consents to the exclusive jurisdiction
of the New York Supreme Court, County of New York, and the United States District Court for the Southern District of New York in any such
suit, action or proceeding. Each of the Company and the Manager further agrees to accept and acknowledge service of any and all process
which may be served in any such suit, action or proceeding in the New York Supreme Court, County of New York, or in the United States
District Court for the Southern District of New York and agrees that service of process upon the Company mailed by certified mail to the
Company’s address shall be deemed in every respect effective service of process upon the Company, in any such suit, action or proceeding,
and service of process upon the Manager mailed by certified mail to the Manager’s address shall be deemed in every respect effective
service process upon the Manager, in any such suit, action or proceeding. If either party shall commence an action or proceeding to enforce
any provision of this Agreement, then the prevailing party in such action or proceeding shall be reimbursed by the other party for its
reasonable attorney’s fees and other costs and expenses incurred with the investigation, preparation and prosecution of such action
or proceeding.
16. Submission
to Jurisdiction. The Company hereby submits to the exclusive jurisdiction of the U.S. federal and New York state courts in the Borough
of Manhattan in The City of New York in any suit or proceeding arising out of or relating to this Agreement or the transactions contemplated
hereby. The Company waives any objection which it may now or hereafter have to the laying of venue of any such suit or proceeding in such
courts. The Company agrees that final judgment in any such suit, action or proceeding brought in such court shall be conclusive and binding
upon the Company and may be enforced in any court to the jurisdiction of which Company is subject by a suit upon such judgment.
17. Judgment
Currency. The Company agrees to indemnify the Manager, its directors, officers, affiliates and each person, if any, who controls the
Manager within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, against any loss incurred by the Manager
as a result of any judgment or order being given or made for any amount due hereunder and such judgment or order being expressed and paid
in a currency (the "Judgment Currency") other than U.S. dollars and as a result of any variation as between (i) the rate
of exchange at which the U.S. dollar amount is converted into the Judgment Currency for the purpose of such judgment or order, and (ii)
the rate of exchange at which such indemnified person is able to purchase U.S. dollars with the amount of the Judgment Currency actually
received by the indemnified person. The foregoing indemnity shall constitute a separate and independent obligation of the Company and
shall continue in full force and effect notwithstanding any such judgment or order as aforesaid. The term "rate of exchange"
shall include any premiums and costs of exchange payable in connection with the purchase of, or conversion into, the relevant currency.
18. Waiver
of Immunity. To the extent that the Company has or hereafter may acquire any immunity (sovereign or otherwise) from jurisdiction of
any court of (i) the State of Israel, or any political subdivision thereof, (ii) the United States or the State of New York, (iii) any
jurisdiction in which it owns or leases property or assets or from any legal process (whether through service of notice, attachment prior
to judgment, attachment in aid of execution, execution, set-off or otherwise) with respect to themselves or their respective property
and assets or this Agreement, the Company hereby irrevocably waives such immunity in respect of its obligations under this Agreement to
the fullest extent permitted by applicable law.
19. Waiver
of Jury Trial. The Company hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trial
by jury in any legal proceeding arising out of or relating to this Agreement, any Terms Agreement or the transactions contemplated hereby
or thereby.
20. Counterparts.
This Agreement and any Terms Agreement may be executed in one or more counterparts, each one of which shall be an original, with the same
effect as if the signatures thereto and hereto were upon one and the same agreement. Counterparts may be delivered via electronic mail
(including any electronic signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions Act, the Electronic
Signatures and Records Act or other applicable law, e.g., www.docusign.com) or other transmission method and any counterpart so delivered
shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.
***************************
21. Headings.
The section headings used in this Agreement and any Terms Agreement are for convenience only and shall not affect the construction hereof.
If the foregoing is in accordance
with your understanding of our agreement, please sign and return to us the enclosed duplicate hereof, whereupon this letter and your acceptance
shall represent a binding agreement among the Company and the Manager.
Very truly yours,
CAN-FITE BIOPHARMA lTD. |
|
|
|
By: |
|
|
Name: |
Motti Farbstein |
|
Title: |
Chief Executive Officer and Chief Financial Officer |
|
Address for Notice:
26 Ben Gurion Street
Ramat Gan 5257346 Israel
Attention: Motti Farbstein
E-mail: motti@canfite.co.il
The foregoing Agreement is hereby confirmed and accepted
as of the date first written above.
H.C. WAINWRIGHT & CO., LLC
Address for Notice:
430 Park Avenue
New York, New York 10022
Attention: Chief Executive Officer
E-mail: notices@hcwco.com
Form of Terms Agreement
ANNEX I
CAN-FITE
BIOPHARMA lTD.
TERMS AGREEMENT
Dear Sirs:
Can-Fite
BioPharma Ltd. (the “Company”) proposes, subject to the terms and conditions stated herein and in the At The Market
Offering Agreement, dated August 30, 2024 (the “At The Market Offering Agreement”), between the Company and H.C. Wainwright
& Co., LLC (“Manager”), to issue and sell to Manager the securities specified in the Schedule I hereto
(the “Purchased ADSs”).
Each
of the provisions of the At The Market Offering Agreement not specifically related to the solicitation by the Manager, as agent of the
Company, of offers to purchase securities is incorporated herein by reference in its entirety, and shall be deemed to be part of this
Terms Agreement to the same extent as if such provisions had been set forth in full herein. Each of the representations and warranties
set forth therein shall be deemed to have been made at and as of the date of this Terms Agreement and the Time of Delivery, except that
each representation and warranty in Section 3 of the At The Market Offering Agreement which makes reference to the Prospectus (as
therein defined) shall be deemed to be a representation and warranty as of the date of the At The Market Offering Agreement in relation
to the Prospectus, and also a representation and warranty as of the date of this Terms Agreement and the Time of Delivery in relation
to the Prospectus as amended and supplemented to relate to the Purchased ADSs.
An
amendment to the Registration Statement (as defined in the At The Market Offering Agreement), or a supplement to the Prospectus, as the
case may be, relating to the Purchased ADSs, in the form heretofore delivered to the Manager is now proposed to be filed with the Securities
and Exchange Commission.
Subject
to the terms and conditions set forth herein and in the At The Market Offering Agreement which are incorporated herein by reference, the
Company agrees to issue and sell to the Manager and the latter agrees to purchase from the Company the number of Purchased ADSs at the
time and place and at the purchase price set forth in the Schedule I hereto.
If the foregoing is
in accordance with your understanding, please sign and return to us a counterpart hereof, whereupon this Terms Agreement, including those
provisions of the At The Market Offering Agreement incorporated herein by reference, shall constitute a binding agreement between the
Manager and the Company.
CAN-FITE BIOPHARMA lTD. |
|
By: |
|
|
Name: |
Motti Farbstein |
|
Title: |
Chief Executive Officer and Chief Financial Officer |
|
ACCEPTED as of the date first written above. |
|
H.C. WAINWRIGHT & CO., LLC |
|
By: |
|
|
Name: |
|
|
Title: |
|
|
48
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