hVIVO plc Favourable results for PrEP Biopharm's Flu Study (1438B)
14 June 2016 - 9:00PM
UK Regulatory
TIDMHVO
RNS Number : 1438B
hVIVO plc
14 June 2016
For immediate release 12.00pm: 14 June 2016
HVIVO PLC
("hVIVO" or the "Company")
hVIVO confirms favourable results for PrEP Biopharm's PrEP-001
Phase IIa influenza prophylaxis study
PrEP-001 phase IIa favourable results indicate Proof of
Concept
in an influenza prevention model. Coupled with previous
rhinovirus prevention studies, these data highlight PrEP-001's
pan-viral prophylaxis potential
hVIVO plc (AIM: HVO), the pioneer of human models of disease,
confirms favourable results were achieved in the PrEP-001 Phase IIa
influenza study, indicating proof of concept (POC) of PrEP-001's
prophylactic effect. Initial study results were previously
announced in April 2016. PrEP-001 is a nasally administered,
broad-spectrum agent that leverages the innate immune system to
prevent upper respiratory tract viral infections (colds and flus)
and is the lead program of PrEP Biopharm Limited, a UK biotech
company for respiratory infectious disease products, in which hVIVO
acquired a significant equity stake on 1 November 2015.
The study titled, "A Phase II, Repeated Dose, Double-Blinded,
Randomised, Controlled Study to Examine the Prophylactic Efficacy,
Safety and Tolerability of PrEP-001 in Healthy Subjects
Subsequently Challenged with Influenza A/Perth/16/2009 (H3N2)
Virus" contained 63 subjects and is the first of three Phase IIa
studies to be conducted by hVIVO for PrEP Biopharm. The study's
primary objective focused on assessing the changes in symptoms in
healthy subjects who received PrEP-001 compared to those who
received placebo. The study was held in hVIVO's purpose-built
quarantine unit located in London using hVIVO's influenza disease
model. Two additional Phase IIa studies, a challenge study in
asthmatic patients and a dosing study, are currently ongoing.
Similar to previous PrEP-001 phase IIa results obtained in a
rhinovirus challenge model, final unblinded review of the influenza
study's data confirmed a decrease in the number of symptoms in
subjects in the active treatment group compared to placebo. Review
of safety data confirmed encouraging safety results.
Full results of the trial will be presented at upcoming
scientific conferences and submitted for publication in
peer-reviewed journals.
hVIVO CEO Kym Denny commented, "We are delighted to report the
Proof of Concept for PrEP-001 in influenza, indicating PrEP-001's
potential to have a prophylactic effect across a range of
respiratory viruses. With additional phase IIa studies already
underway, I look forward to relaying further study results on
PrEP-001 in the future."
For further information, please contact:
hVIVO plc +44 207 756 1300
Kym Denny (Chief Executive Officer)
Graham Yeatman (Chief Financial & Business Officer)
Media Enquiries +44 203 021 3933 / +44 7854 979 420
Colin Paterson (Director of Marketing, Communication and Public
Relations)
Numis Securities Limited +44 207 260 1000
Michael Meade / Freddie Barnfield (Nominated Adviser)
James Black / Michael Burke (Corporate Broking)
Notes to Editors:
About hVIVO
hVIVO plc ("hVIVO") is a life sciences company pioneering a
technology platform of human disease models to accelerate drug
discovery and development in respiratory and infectious diseases,
including flu, RSV, asthma and common cold. hVIVO has
commercialised four disease models, successfully enrolled over
2,000 subjects and conducted over 40 product validation studies for
a wide range of industry, government and academic clients and
collaborators.
This information is provided by RNS
The company news service from the London Stock Exchange
END
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