Daxor's Blood Volume Analysis Uncovers Hidden Heart Failure Subtype in Nearly 1 in 5 Patients, Enabling Targeted Treatment
15 February 2025 - 12:00AM
Daxor Corporation (Nasdaq: DXR), the global leader in blood volume
measurement technology, today announces a groundbreaking case
series published in JACC: Case Reports has identified a distinct
phenotype in heart failure patients characterized by expanded blood
volume overload and elevated red blood cells, opening new avenues
for targeted treatment through therapeutic phlebotomy. In the
study, researchers evaluated 179 advanced heart failure patients
using Daxor's blood volume analysis (BVA). Through this analysis,
they identified thirty-six patients and closely monitored four
heart failure cases over a 12-month period, helping to detect an
under-recognized condition.
In the clinical case series, titled,
"Identification and Treatment of Hypervolemia and Polycythemia in
Patients With Advanced Heart Failure,” researchers discovered that
20% (36 patients) exhibited this specific hypervolemia/polycythemia
phenotype. Among these cases, four patients were selected for
therapeutic phlebotomy based on their functional status and risk
factors.
Key Takeaways:
- BVA detects
critical volume issues missed by standard blood tests that drive
patient outcomes.
- This condition affects
700,000-1,400,000 US heart failure patients (10-20% of ambulatory
cases).
- Patients with this phenotype show
worse clinical outcomes than typical heart failure cases.
- Higher stroke and blood clot risks
pose additional clinical challenges for these patients if
untreated.
- Therapeutic
phlebotomy guided by BVA showed significant symptom improvement
with zero hospitalizations/deaths over 12 months.
"BVA evaluation is an extremely useful and
specific diagnostic test,” said Marc A. Silver, MD, Banner
University Medical Center, Advanced Heart Failure, MCS and Heart
Transplant, the study's principal investigator. "BVA offers
precise, otherwise undetected derangements and insights into the
risk of thrombotic events.”
John L. Jefferies, MD, MBA, MPH, Daxor’s Chief
Medical Officer, stated, “Optimal volume management is crucial in
heart failure care, and these case studies highlight BVA’s
unmatched accuracy in identifying patients’ true volume status. By
providing precise, individualized guidance, BVA enables clinicians
to tailor interventions more effectively, enhancing patient
outcomes.”
About Daxor Corporation
Daxor Corporation (Nasdaq: DXR), is the global
leader in blood volume measurement technology focused on blood
volume testing innovation. We developed and market the BVA-100®
(Blood Volume Analyzer), the only diagnostic blood test cleared by
the FDA to provide safe, accurate, objective quantification of
blood volume status and composition compared to patient-specific
norms. Over 65,000+ tests have been performed at leading hospital
centers across the U.S., enhancing hospital performance metrics in
a broad range of surgical and medical conditions, including
significantly reducing mortality and readmissions in heart failure
and critical care. Daxor has several ongoing trials in the areas of
heart failure treatment with support from the NIH and is under
contract developing analyzers to improve combat casualty care with
the U.S. Department of Defense. Daxor's mission is to advance
healthcare by enabling optimal fluid management with blood volume
analysis. Daxor’s vision is optimal blood volume for all. For more
information, please visit our website at Daxor.com. Sign up to
receive news on Daxor’s innovative technology HERE.
Forward-Looking Statements
Certain statements in this release may include
forward-looking statements within the meaning of the Private
Securities Litigation Reform Act of 1995, including without
limitation, statements regarding the impact of hiring sales staff
and expansion of our distribution channels. Forward-looking
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future events that are based on current expectations and
assumptions and, as a result, are subject to risks and
uncertainties. Many factors could cause actual future events to
differ materially from the forward-looking statements in this
release, including, without limitation, those risk associated with
our post-market clinical data collection activities, benefits of
our products to patients, our expectations with respect to product
development and commercialization efforts, our ability to increase
market and physician acceptance of our products, potentially
competitive product offerings, intellectual property protection,
FDA regulatory actions, our ability to integrate acquired
businesses, our expectations regarding anticipated synergies with
and benefits from acquired businesses, and additional other risks
and uncertainties described in our filings with the SEC.
Forward-looking statements speak only as of the date when made.
Daxor does not assume any obligation to publicly update or revise
any forward-looking statements, whether as a result of new
information, future events or otherwise.
Investor Relations Contact:Bret ShapiroSr.
Managing Partner, CORE IR1-516-222-2560brets@coreir.com
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