Second Study Supports that NGAL Test Identifies Acute Kidney Injury Early in Critically Ill Patients
18 December 2009 - 1:00AM
PR Newswire (US)
WALTHAM, Mass., Dec. 17 /PRNewswire-FirstCall/ -- According to a
new study published last week in Intensive Care Medicine, a novel
bedside blood test measured in critically ill patients being
admitted to the intensive care unit can help to identify which
patients are at risk for acute kidney injury (AKI). The study
carried out in Vicenza, Italy, tested blood samples collected
during admission to the ICU using the TriageĀ® NGAL Test, a product
currently sold by Inverness Medical Innovations, Inc. (NYSE:IMA)
outside of the United States.* AKI is a common and often
devastating complication for up to 25% of critically ill patients
admitted to the ICU. AKI can lead to increasing hospital length of
stay and associated costs, and also increases risk of death. AKI is
often detected too late into its clinical progression when a
substantial portion of kidney function may already have been lost
and the window for initiating treatment to prevent further harm has
closed. Earlier this year a small study conducted at the University
Hospital of Clermont-Ferrand, France and published in the Journal
of Critical Care found that a new bedside blood test for a blood
biomarker called neutrophil gelatinase-associated lipocalin (NGAL)
offered the promise of rapidly assessing if a critically ill
patient is suffering from AKI. Now results from the prestigious
Department of Nephrology at San Bortolo Hospital in Vicenza Italy
have confirmed these findings in a larger study published this week
in Intensive Care Medicine. In this study of 301 critically ill
patients, plasma NGAL measured with the Triage NGAL Test was a
statistically significant diagnostic marker for AKI development
within the next 48 hours (area-under-ROC 0.78), and for renal
replacement therapy use (area-under-ROC 0.82). Moreover, peak
plasma NGAL concentrations increased with worsening AKI severity
(R=0.554, p