RNS Number:0421O
Profile Therapeutics PLC
28 July 2003

Letter to Profile Therapeutics plc

Companies Act 1985 - Disclosure of Interests In Shares

In accordance with sections 198 - 202 of the above Act (as amended by the
Companies Act 1989 and the Disclosure of Interests in Shares (Amendment)
Regulations 1993) we hereby notify you of a change in the interest of 3i Group
plc in the share capital of your company which is notifiable under the
provisions of the Act and which is detailed below.

Registered Holder               Beneficial Owner          Ordinary Shares of 2p
BNY (OCS) Nominees Limited      3i Group plc                          9,697,267
a/c 3i plc                                               
BNY (OCS) Nominees Limited      3i Bioscience                           544,117
a/c 3iBio                       Investment Trust plc                    

Total                                                                10,241,384

3i Holdings plc, 3i plc and 3i Investments plc are also interested in the shares 
beneficially owned by 3i Bioscience Investment Trust plc.


From 3i Group plc



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