TIDMFAB

RNS Number : 4785V

Fusion Antibodies PLC

04 December 2023

Prior to publication, the information contained within this announcement was deemed by the Company to constitute inside information for the purposes of Article 7 under the Market Abuse Regulations (EU) No. 596/2014 ("MAR"). With the publication of this announcement, this information is now considered to be in the public domain.

4 December 2023

Fusion Antibodies plc

("Fusion" or the "Company")

Half year Report

Fusion Antibodies plc (AIM: FAB), an Early Discovery Contract Research Organisation ("CRO") specialising in pre-clinical antibody discovery, engineering and supply for both therapeutic drug and diagnostic applications, announces its unaudited interim results for the six months ended 30 September 2023 ("H1 FY2024") and provides an update on recent commercial progress.

Operational highlights

   --    Increased numbers of commercial opportunities identified and improving pipeline valuation 
   --    A number of projects delayed by clients as they seek further investment 

-- Progress in development of the OptiMAL(R) library, with demonstration of whole IgG antibodies expressed on the cell surface

   --    GBP1.67 million fundraise alongside GBP1.6 million cost rationalisation exercise 
   --    Appointment of Stephen Smyth as interim CFO 

Financial highlights

   --    Revenue of GBP541k (H1 FY2023: GBP1.9 million) 
   --    Expenditure on R&D decreased by 60% to GBP0.18 million (H1 FY2023: GBP0.45 million) 
   --    Loss of GBP1.4 million (H1 FY2023: GBP1.1 million loss) 
   --    Cash position at 30 September 2023 was GBP0.5 million (31 March 2023: GBP0.2 million) 

Post-period highlights

-- Collaboration Agreement with the National Cancer Institute, USA ("NCI") to validate OptiMAL(R)

   --    First AI/ML-Ab(TM) project successfully completed 
   --    Further pipeline progression and increased rate of deal closures 
   --    FY2024 results expected to be significantly weighted towards the second half of the year 

Commenting on the interim results, Adrian Kinkaid, CEO of Fusion Antibodies plc, said: "During this calendar year, the industry has been experiencing significant headwinds especially in the venture capital ("VC") funded biotech sector. A number of clients have consequently delayed initiating their projects with us. Nonetheless, we have generated a significantly stronger pipeline which includes a wider diversity of clients that are less dependent on VC funding. Consequently, whilst overall revenues for the period are low as previously announced, through our efforts we have benefitted from a trend of increasing month-on-month revenues throughout the H1 FY2024 period, which we hope will continue to strengthen in the remainder H2 and beyond.

" It is particularly encouraging to see our newer offerings also being well received with our first AI/ML-Ab(TM) contract being successfully completed and, post-period end, securing the agreement with the NCI to help validate OptiMAL(R). Both of these developments are having a positive impact on market awareness and engagement."

Investor presentation via Investor Meet Company

Fusion will host a presentation on the results open to all investors via the Investor Meet Company platform at 11.00 a.m. on Thursday, 7(th) December 2023, delivered by Dr Adrian Kinkaid, CEO and Mr Stephen Smyth, CFO. The Company is committed to providing an opportunity for all existing and potential investors to hear directly from management on its results whilst additionally providing an update on the business and current trading.

I nvestors can sign up to Investor Meet Company for free and add to meet Fusion Antibodies plc via the following link: https://www.investormeetcompany.com/fusion-antibodies-plc/register-investor

Enquiries:

 
 Fusion Antibodies plc                            www.fusionantibodies.com 
 Adrian Kinkaid PhD, Chief Executive              Via Walbrook PR 
  Officer 
 S tephen Smyth , Chief Financial Officer 
 
 Allenby Capital Limited                          Tel: +44 (0)20 3328 5656 
 James Reeve / Vivek Bhardwaj (Corporate 
  Finance) 
 Tony Quirke/Joscelin Pinnington (Sales 
  and Corporate Broking) 
 
 Walbrook PR                     Tel: +44 (0)20 7933 8780 or fusion@walbrookpr.com 
 Anna Dunphy                                              Mob: +44 (0)7876 741 001 
 
 

About Fusion Antibodies plc

Fusion is a Belfast-based Collaborative Research Organisation ("CRO") company, listed on AIM, providing an integrated end-to-end range of antibody engineering services for the development of antibodies for both therapeutic drug and diagnostic applications.

Fusion provides a broad range of services in antibody generation, development, characterisation, optimisation, and small-scale production. These services include antigen expression, purification and sequencing, antibody humanisation using Fusion's proprietary CDRx(TM) platform and cell line development, producing antibody generating stable cell lines optimised for use downstream by the customer to produce material for clinical trials. Since 2012, the Company has successfully sequenced and expressed over 250 antibodies and successfully completed over 200 humanisation projects for its international customer base, which has included eight of the top 10 global pharmaceutical companies by revenue.

At every stage, our client's vision is central to how we work in combining the latest technological advances with cutting edge science. In this work our world-class humanization and antibody optimization platforms harness the power of natural somatic hypermutation (SHM) to ensure the best molecule goes to the clinic. Fusion Antibodies' growth strategy is based on enabling Pharma and Biotech companies get to the clinic more effectively, using molecules with optimized therapeutic profile and enhanced potential for successful development and approval and, ultimately, on speeding up the drug discovery and development process. The announced Integrated Therapeutic Antibody Services ("ITA") offering will enhance the efficiency of this process by providing a continuous service offering from target nomination to stable cell line. Fusion's use of SHM to create a fully human antibody library to capture the human antibody repertoire will address a continuing market need in antibody discovery.

Fusion Antibodies' emphasis on antibody therapeutics is based on the size and growth rate in the sector, with the market valued at $186 billion in 2021 and forecast to surpass $400 billion by 2028. As of June 2022, there were 150 approved antibody therapies on the market and nearly 600 antibody drugs in clinical trials.

Operational Review

As announced on 29 September 2023, at the time of publication of its annual report for the year ended 31 March 2023 ("FY2023"), the Company has been experiencing a commercially challenging period, primarily due to weak market conditions for investment in new drug discovery and development programmes and the subsequent delays to a number of anticipated contracts, both large and small. The Company had anticipated an easing of these constraints during H1 FY2024, however, this has not materialised as quickly as expected. Consequently, trading conditions remain very challenging and revenue for H1 FY2024 is GBP541k. Towards the end of the period, several projects were subject to certain technical challenges which required additional work to be undertaken, thereby pushing some of the expected H1 recognised revenue into H2. The remainder of the shortfall was due to a delayed project initiation.

Revenues for FY2024 are expected to be significantly weighted towards the second half of the year, and the Board remain optimistic that our new services, such as AI/ML-Ab(TM) , will have an impact, and contribute positively to revenue growth in the second half. The Company has achieved a marked growth in its pipeline of sales opportunities with overall values now standing at approximately four times that of six months ago. Part of the pipeline growth is attributable to enhanced penetration of adjacent markets (including Veterinary Medicine, Diagnostics and Research Antibodies) in line with our previously stated strategy. These factors bode well for the Company's future provided opportunities can be progressed and converted into work in progress.

In June 2023, the Company successfully completed a GBP1.5m fundraise (net of expenses) to provide additional working capital and we have now implemented circa. GBP1.6m in restructuring savings, including a reduction in headcount from 48 at 31 March 2023 to 29 at 30 September 2023. We are seeking to identify additional cost savings that can be implemented without further impacting on the operating capacity of the Company. A significant program of cross training of staff from different laboratories has been completed which maintains the capability to deliver all of our services.

In August 2023, we announced that the negotiations with a leading AI/ML (artificial intelligence/machine learning) company based in the USA had been finalised and that we received our first order from this new collaboration to generate de-novo antibody sequences. This AI/ML platform, known as the AI/ML-Ab (TM) service (pronounced "AIM Lab"), provides a method of designing panels of antibodies in-silico, with the AI/ML algorithms typically producing small libraries of sequences which are an excellent match with our Mammalian Display platform, which emanated from the OptiMAL(R) library development program. These designs are transformed into real protein molecules for screening and final selection and is a potentially powerful combination to speed up the discovery process.

Our Integrated Therapeutic Antibody Service (ITAS) that integrates our current Discovery, Engineering and Supply services into one proposition, continues to gain attention and our R&D program to develop a cell-based mammalian display technology screening library, OptiMAL(R), is progressing, with key stages of the process now developed. As announced in our annual report for the year ended 31 March 2023 ("FY2023"), w e now have clear evidence that our highly diverse library of DNA sequences are expressed as fully intact antibodies on the surface of mammalian cells. With the antibody on the cell surface, a cell can be individually selected and manipulated to produce larger quantities of the antibody of interest, although further optimisation work is still required to deliver the full operational screening parameters. The goal of this cell-based process is to directly identify intact fully human antibodies against biomarkers and other targets of interest and is in line with the antibody drug discovery industry's aim to gradually moving away from the use of animals.

We will continue to build a body of data with a view to establishing commercial relationships for further validation and we recently announced our first validation partner. The Company has signed a Collaboration Agreement (the "Agreement") with the National Cancer Institute, USA (NCI) to validate OptiMAL (R) . Under the terms of the Agreement, Fusion will provide access to the OptiMAL(R) technology to NCI for the discovery of novel antibodies against an agreed number of primarily cancer targets selected by NCI over a period of up to two years in order to develop potential therapeutic antibodies. The parties will work together to ensure successful validation of the OptiMAL (R) technology and jointly publish any results from the collaboration at various times over the two-year period, although as with any R&D project the timing of any results from the collaboration cannot be predicted.

We have seen the first of the results in our strategy to grow sales through penetration of adjacent markets. We recently announced t he signing of a commercial contract with a US-based diagnostic company to develop production quality cell lines using our new Mammalian Display technology, for the expressions of a range of proteins, other than antibodies, showing the flexibility of the technology. An initial feasibility study will be performed on a fee-for-service basis for two difficult to produce reagents. The study, if successful, can be expanded to a much larger portfolio of reagents.

Board changes

Changes in the board composition during the period to September 2023 was the appointment of Stephen Smyth as the interim CFO / Company secretary following the resignation of James Fair (CFO). In addition, post period end, Sonya Ferguson stepped down as a non-Executive Director of the Company.

Financial Review

Revenues for the six-month period ending 30 September 2023 were GBP0.54 million (H1 FY2023: GBP1.86 million). All revenues were derived from services and they contained no milestone or royalty payments.

The (15)% gross profit percentage for H1 FY2024 (H1 FY2023: 33%) was lower than in the same period last year due to a service based labour fixed cost in place in readiness for an increased revenue.

R&D expenditure in H1 FY2024 was GBP182k (H1 FY2023: GBP452k), a decrease of 60% over the comparable period. SG&A expenditure of GBP1,153k was GBP266k lower than in H1 FY2023 (GBP1,419k) and, despite significantly lower revenue than H1 FY2023, the operating loss for H1 FY2024 was GBP1.36 million (H1 FY2023: GBP1.26 million loss). The reduction in R&D expenditure, S&G expenditure and small increase in operating loss relative to the reduction in revenues are all primarily due to the restructuring and cost saving measures that were in the process of being implemented during H1 FY2024.

Cash used in operations was GBP1,213k compared with GBP754k used in H1 FY2023. The H1 FY2024 operational outflow includes the GBP182k investment in R&D. The total inflow was GBP291k and the closing cash balance at 30 September 2023 was GBP487,000.

Key Performance Indicators

The key performance indicators (KPIs) regularly reviewed by the Board are:

 
 KPI                          H1 FY2024     H1 FY2023 
---------------------------  ------------  ------------ 
 Underlying revenue growth    (71)%         (19)% 
 EBITDA*                      (GBP1.231m)   (GBP1.008m) 
 Cash used in operations      (GBP1.351m)   (GBP0.754m) 
---------------------------  ------------  ------------ 
 

* Earnings before interest, tax, depreciation and amortisation

The investment in R&D and the impact on EBITDA is set out in Note 12 to these statements. EBITDA for the period was a loss of GBP1.231 million (H1 FY2023: GBP1.008 million loss) and adjusting for research and development expenditure shows an EBITDA loss excluding R&D of GBP1.049 million for the period (H1 FY2023: GBP0.5560 million loss).

Outlook

The Board is confident that Fusion's prospects for growth are increasingly positive and the new novel technologies available to the Company, especially AI/ML-Ab(TM) and OptiMAL(R), will play an important role in differentiating the business and creating fresh value for our shareholders.

Revenues for FY2024 are expected to be significantly weighted towards the second half of the financial year. This is supported by the revenue growth trend observed through H1 FY2024 and the marked growth in its sales opportunities pipeline over the last six months. Additionally, the recent news regarding OptiMAL(R) has raised the Company's profile with new connections being made with significant prospective clients, further enhancing our strategy of penetration into adjacent markets including Veterinary Medicine, Diagnostics and Research Antibodies.

It remains a key strategic focus for the Company to achieve cash neutrality. The Company continues to maintain stringent cost controls, closely monitor the cash runway, and will seek to identify additional cost savings that can be implemented without further impacting the operating capacity of the Company.

Statement of Directors' Responsibilities

The Directors confirm, to the best of their knowledge:

-- The condensed set of financial statements has been prepared in accordance with IAS34 'Interim Financial Reporting';

-- The interim management report includes a fair review of the information required by DTR 4.2.7R of the Disclosure and Transparency Rules of the of the United Kingdom's Financial Conduct Authority, being an indication of important events that have occurred during the first six months of the financial year and their impact on the condensed set of financial statements, and a description of the principal risks and uncertainties for the remaining six months of the year, and gives a true and fair view of the assets, liabilities, financial positions and profit for the period of the Company; and

-- The interim management report includes a fair review of the information required by DTR 4.2.8R of the Disclosure and Transparency Rules of the United Kingdom's Financial Conduct Authority, being a disclosure of related party transactions and changes therein since the previous annual report.

On behalf of the Board

Dr Simon Douglas

Non-executive Chairman

04 December 2023

Condensed Statement of Comprehensive Income

For the six months ended 30 September 2023

 
 
 
 
 
                                                6 months       6 months     Year to 
                                             to 30.09.23    to 30.09.22    31.03.23 
                                               Unaudited      Unaudited     Audited 
                                    Notes        GBP'000        GBP'000     GBP'000 
 Revenue                                             541          1,863       2,901 
 Cost of sales                                     (625)        (1,256)     (2,327) 
-------------------------------  --------  -------------  -------------  ---------- 
 
   Gross profit                                     (84)            607         574 
 
   Other operating income              10              -              8          11 
 Administrative expenses                3        (1,335)        (1,871)     (3,443) 
-------------------------------  --------  -------------  -------------  ---------- 
 Operating loss                                  (1,419)        (1,256)     (2,858) 
-------------------------------  --------  -------------  -------------  ---------- 
 
 Finance income                         4              2              1           3 
 Finance costs                          4            (3)            (7)         (4) 
-------------------------------  --------  -------------  -------------  ---------- 
 Loss before tax                                 (1,420)        (1,262)     (2,859) 
 
   Income tax credit                    5             63            146         263 
-------------------------------  --------  -------------  -------------  ---------- 
 
   Loss for the period                           (1,357)        (1,116)     (2,596) 
 
   Total comprehensive expense 
   for the period                                (1,357)        (1,116)     (2,596) 
-------------------------------  --------  -------------  -------------  ---------- 
 
 
                                                   Pence          Pence       Pence 
 Basic loss per share                   6          (2.3)          (4.3)      (10.0) 
 
 

Condensed Statement of Financial Position

As at 30 September 2023

 
 
 
 
 
                                                    As at   As at 30.09.22       As at 
                                                 30.09.23        Unaudited    31.03.23 
                                                Unaudited          GBP'000     Audited 
                                       Notes      GBP'000                      GBP'000 
----------------------------------  --------  -----------  ---------------  ---------- 
 Assets 
 Non-current assets 
 Intangible assets                                      -                -           - 
 Property, plant and equipment             7          250              743         375 
                                                      250              743         375 
----------------------------------  --------  -----------  ---------------  ---------- 
 Current assets 
 Inventories                                          524              552         539 
 Trade and other receivables                          471            1,212         690 
 Current tax receivable                               326              277         263 
 Cash and cash equivalents                            487            1,198         195 
----------------------------------  --------  -----------  ---------------  ---------- 
                                                    1,808            3,329       1,687 
----------------------------------  --------  -----------  ---------------  ---------- 
 Total assets                                       2,058            3,982       2,062 
----------------------------------  --------  -----------  ---------------  ---------- 
 
 
 Liabilities 
 Current liabilities 
 Trade and other payables                             537            1,057         844 
 Borrowings                                8           17               83          35 
----------------------------------  --------  -----------  ---------------  ---------- 
                                                      554            1,140         879 
----------------------------------  --------  -----------  ---------------  ---------- 
 
 Net current assets                                 1,254            2,100         808 
 
 Non-current liabilities 
 Borrowings                                8           30              250          40 
 Provisions for other liabilities 
  and charges                                          20               20          20 
----------------------------------  --------  -----------  ---------------  ---------- 
 Total liabilities                                    604            1,410          60 
----------------------------------  --------  -----------  ---------------  ---------- 
 
 Net assets                                         1,454            2,572       1,123 
----------------------------------  --------  -----------  ---------------  ---------- 
 
 Equity 
 Called up share capital                  12        2,378            1,040       1,040 
 Share premium reserve                              7,981            7,647       7,647 
 (Accumulated losses)/retained 
  earnings                                        (8,905)          (6,115)     (7,564) 
----------------------------------  --------  -----------  ---------------  ---------- 
 Equity                                             1,454            2,572       1,123 
----------------------------------  --------  -----------  ---------------  ---------- 
 

Condensed Statement of Changes in Equity

For the six months ended 30 September 2023

 
 
 
 
 
 6 months ended 30 September        Called           Share   Accumulated      Total 
  2023                            up share         premium        losses     Equity 
  Unaudited                        capital         reserve       GBP'000    GBP'000 
                                   GBP'000         GBP'000 
------------------------------  ----------  --------------  ------------  --------- 
 At 1 April 2023                     1,040           7,647       (7,564)      1,123 
 Loss for the period                     -               -       (1,357)    (1,357) 
------------------------------  ----------  --------------  ------------  --------- 
 Issue of share capital              1,338             334             -      1,672 
 Share options - value 
  of employee services                   -               -            16         16 
------------------------------  ----------  --------------  ------------  --------- 
 Total transactions with 
  owners, recognised directly 
  in equity                              -               -            16         16 
------------------------------  ----------  --------------  ------------  --------- 
 At 30 September 2023                2,378           7,981       (8,905)      1,454 
------------------------------  ----------  --------------  ------------  --------- 
 
 6 months ended 30 September        Called   Share premium      Retained      Total 
  2022                            up share         reserve      earnings     Equity 
  Unaudited                        capital         GBP'000       GBP'000    GBP'000 
                                   GBP'000 
------------------------------  ----------  --------------  ------------  --------- 
 At 1 April 2022                     1,040           7,647       (5,003)      3,684 
 Loss for the period                     -               -       (1,116)    (1,116) 
------------------------------  ----------  --------------  ------------  --------- 
 Issue of share capital                  -               -             -          - 
 Share options - value of 
  employee services                      -               -             4          4 
 Total transactions with 
  owners, recognised directly 
  in equity                              -               -             4          4 
------------------------------  ----------  --------------  ------------  --------- 
 At 30 September 2022                1,040           7,647       (6,115)      2,572 
------------------------------  ----------  --------------  ------------  --------- 
 
 Year ended 30 March 2023           Called   Share premium   Accumulated      Total 
  Audited                         up share         reserve        losses     Equity 
                                   capital         GBP'000       GBP'000    GBP'000 
                                   GBP'000 
------------------------------  ----------  --------------  ------------  --------- 
 At 1 April 2022                     1,040           7,647       (5,003)      3,684 
 Loss for the year                       -               -       (2,596)    (2,596) 
------------------------------  ----------  --------------  ------------  --------- 
 Share options - value of 
  employee services                      -               -            35         35 
 Total transactions with 
  owners, recognised directly 
  in equity                              -               -            35         35 
------------------------------  ----------  --------------  ------------  --------- 
 At 31 March 2023                    1,040           7,647       (7,564)      1,123 
------------------------------  ----------  --------------  ------------  --------- 
 

Statement of Cash Flows

For the six months ended 30 September 2023

 
 
 
 
 
                                                           6 months     Year to 
                                            6 months    to 30.09.22    31.03.23 
                                                  to      Unaudited     Audited 
                                            30.09.23        GBP'000     GBP'000 
                                           Unaudited 
                                             GBP'000 
---------------------------------------  -----------  -------------  ---------- 
 Cash flows from operating activities 
 Loss for the period                         (1,357)        (1,116)     (2,596) 
 Adjustments for: 
 Share based payment expense                      16              4          35 
 Depreciation                                    125            248         372 
 Amortisation of intangible assets                 -              -           - 
 Finance income                                  (2)            (1)         (3) 
 Finance costs                                     3              7           4 
 Income tax credit                              (63)          (146)       (263) 
 Decrease/(increase) in inventories               15             32          46 
 Decrease/(increase) in trade and 
  other receivables                              219            304         819 
 (Decrease)/increase in trade and 
  other payables                               (307)           (86)       (299) 
---------------------------------------  -----------  -------------  ---------- 
 Cash used in operations                     (1,351)          (754)     (1,885) 
 Income tax received                               -              -         131 
---------------------------------------  -----------  -------------  ---------- 
 Net cash used in operating activities       (1,351)          (754)     (1,754) 
 
 Cash flows from investing activities 
 Purchase of property, plant and 
  equipment                                        -          (358)       (114) 
 Finance income - interest received                2              1           3 
---------------------------------------  -----------  -------------  ---------- 
 Net cash generated by/(used in) 
  investing activities                             2          (357)       (111) 
 
 Cash flows from financing activities 
 Proceeds from issue of share capital          1,672              -           - 
 Proceeds from new borrowings                      -            323          69 
 Repayments of borrowings                       (28)           (56)        (62) 
 Finance costs - interest paid                   (3)            (7)         (4) 
---------------------------------------  -----------  -------------  ---------- 
 Net cash generated from financing 
  activities                                   1,641            260           3 
 
 Net increase/(decrease) in cash 
  and cash equivalents                           292          (851)       1,862 
 Cash and cash equivalents at the 
  beginning of the period                        195          2,049       2,049 
---------------------------------------  -----------  -------------  ---------- 
 Effects of exchange rate changes 
  on cash and cash equivalents                                                8 
---------------------------------------  -----------  -------------  ---------- 
 
   Cash and cash equivalents at the 
   end of the period                             487          1,198         195 
---------------------------------------  -----------  -------------  ---------- 
 

Notes to the Interim Results

For the six months ended 30 September 2023

 
 
 
 
   1              Basis of Preparation 

The condensed financial statements comprise the unaudited results for the six months to 30 September 2023 and 30 September 2022 and the audited results for the year ended 31 March 2023. The financial information for the year ended 31 March 2023 does not constitute the full statutory accounts for that period. The Annual Report and Financial Statements for the year ended 31 March 2023 have been filed with the Registrar of Companies. The Independent Auditor's Report on the Annual Report and Financial Statements for the year ended 31 March 2023 was unmodified and did not contain a statement under s498(2) or s498(3) of the Companies Act 2006. The Auditor's report contained a material uncertainty related to going concern.

The condensed financial statements for the period ended 30 September 2023 have been prepared in accordance with the Disclosure and Transparency Rules of the Financial Conduct Authority and with IAS 34 'Interim Financial Reporting' as adopted by the UK. The information in these condensed financial statements does not include all the information and disclosures made in the annual financial statements.

Going concern

At 30 September 2023 the Company had a cash balance of GBP0.5 million. The Directors have reviewed detailed projections for the Company. These projections are based on estimates of future performance and have been adjusted to reflect various scenarios and outcomes that could potentially impact the forecast outturn. Based on these estimates, the Directors have a reasonable expectation that the Company has adequate resources to continue in operational existence for 12 months from the reporting date. Accordingly, they have prepared these condensed financial statements on the going concern basis.

The Directors note that there is inherent uncertainty in any cash flow forecast, however this is further exacerbated given the nature of the Company's trade and the industry in which it operates. Due to the risk that revenues and the related conversion of revenue to cash inflows may not be achieved as forecast over the going concern period, the Directors believe that there exists a material uncertainty that may cast significant doubt on the Company's ability to continue as a going concern and it may be unable to realise its assets and discharge its liabilities in the normal course of business.

These financial statements do not include the adjustments that would result if the Company were unable to continue as a going concern.

Accounting policies

The condensed financial statements have been prepared in a manner consistent with the accounting policies set out in the financial statements for the year ended 31 March 2023 and on the basis of the International Financial Reporting Standards (IFRS) as adopted for use in the UK that the Company expects to be applicable at 31 March 2023. IFRS are subject to amendment and interpretation by the International Accounting Standards Board (IASB).

   2              Segmental information 

For all the financial periods included in these condensed financial statements, all the revenues and costs relate to the single operating segment of research, development and manufacture of recombinant proteins and antibodies.

   3              Administrative expenses 
 
                                            6 months       6 months     Year to 
                                         to 30.09.23    to 30.09.22    31.03.23 
                                           Unaudited      Unaudited     Audited 
                                             GBP'000        GBP'000     GBP'000 
-------------------------------------  -------------  -------------  ---------- 
 Research & development                          182            452         807 
 Selling, general and administration           1,153          1,419       2,636 
-------------------------------------  -------------  -------------  ---------- 
                                               1,335          1,871       3,443 
-------------------------------------  -------------  -------------  ---------- 
 
   4              Finance income and costs 
 
                                  6 months       6 months     Year to 
                               to 30.09.23    to 30.09.22    31.03.23 
                                 Unaudited      Unaudited     Audited 
   Income                          GBP'000        GBP'000     GBP'000 
---------------------------  -------------  -------------  ---------- 
 Bank interest receivable                2              1           3 
---------------------------  -------------  -------------  ---------- 
 
                                  6 months       6 months     Year to 
                               to 30.09.23    to 30.09.22    31.03.23 
                                 Unaudited      Unaudited     Audited 
   Expense                         GBP'000        GBP'000     GBP'000 
---------------------------  -------------  -------------  ---------- 
 Interest expense on other 
  borrowings                             3              7           4 
---------------------------  -------------  -------------  ---------- 
 
   5              Income tax credit 
 
                    6 months       6 months     Year to 
                 to 30.09.23    to 30.09.22    31.03.23 
                   Unaudited      Unaudited     Audited 
                     GBP'000        GBP'000     GBP'000 
-------------  -------------  -------------  ---------- 
 Current tax            (63)          (146)       (263) 
-------------  -------------  -------------  ---------- 
 
   6              Loss per share 
 
                             6 months   6 months to     Year to 
                                   to      30.09.22    31.03.23 
                             30.09.23     Unaudited     Audited 
                            Unaudited        Number      Number 
                               Number 
------------------------  -----------  ------------  ---------- 
 Loss for the financial 
  year                        (1,357)       (1,116)     (2,596) 
------------------------  -----------  ------------  ---------- 
 Loss per share                 pence         pence       pence 
 Basic                          (2.3)         (4.3)      (10.0) 
 Diluted                        (2.9)         (4.3)      (10.0) 
------------------------  -----------  ------------  ---------- 
 
   6              Loss per share (continued) 

The weighted average number of shares used in the calculation of the basic earnings per share are as follows:

 
                                   6 months    6 months to        Year to 
                                         to       30.09.22       31.03.23 
                                   30.09.23      Unaudited        Audited 
                                  Unaudited         Number         Number 
                                     Number 
----------------------------  -------------  -------------  ------------- 
 Issued ordinary shares 
  at the end of the period       59,453,714     26,014,946     26,014,946 
 Weighted average number 
  of shares in issue during 
  the period                     46,496,775     26,014,946     26,014,946 
----------------------------  -------------  -------------  ------------- 
 

Basic earnings per share is calculated by dividing the basic earnings for the period by the weighted average number of shares in issue during the period. Diluted earnings per share is calculated by dividing the basic earnings for the year by the diluted weighted average number of shares in issue inclusive of share options outstanding at year end.

   7              Property, plant and equipment 
 
                                Right   Leasehold        Plant      Fixtures,      Total 
                               of use    property            &       fittings    GBP'000 
                               assets     GBP'000    machinery    & equipment 
                              GBP'000                  GBP'000        GBP'000 
--------------------------  ---------  ----------  -----------  -------------  --------- 
 Cost 
 At 1 April 2023                   14         844        2,396            277      3,531 
 Additions                          -           -            -              -          - 
 Disposals                          -           -            -              -          - 
--------------------------  ---------  ----------  -----------  -------------  --------- 
 At 30 September 2023              14         844        2,396            275      3,531 
--------------------------  ---------  ----------  -----------  -------------  --------- 
 
 Accumulated depreciation 
 At 1 April 2023                    9         812        2,112            223      3,156 
 Disposals                          -           -            -              -          - 
 Depreciation charged 
  in the period                     2          17           93             13        125 
--------------------------  ---------  ----------  -----------  -------------  --------- 
 At 30 September 2023              11         829        2,205            236      3,281 
--------------------------  ---------  ----------  -----------  -------------  --------- 
 
 Net book value 
 At 30 September 
  2023                              3          15          191             41        250 
--------------------------  ---------  ----------  -----------  -------------  --------- 
 At 31 March 2023                   5          32          284             54        375 
--------------------------  ---------  ----------  -----------  -------------  --------- 
 
   8              Borrowings 
 
                             At 30 September   At 30 September   At 31 March 
                                        2023              2022          2023 
                                     GBP'000           GBP'000       GBP'000 
--------------------------  ----------------  ----------------  ------------ 
 At 1 April                               75                69            69 
 Additions in period                       -               323            69 
 Interest                                  3                 7             4 
 Repayments                             (31)              (66)          (67) 
--------------------------  ----------------  ----------------  ------------ 
 At period end                            47               333            75 
--------------------------  ----------------  ----------------  ------------ 
 
 Amounts due in less than 
  1 year                                  17                83            35 
 Amounts due after more 
  than 1 year                             30               250            40 
--------------------------  ----------------  ----------------  ------------ 
                                          47               333            75 
--------------------------  ----------------  ----------------  ------------ 
 

Borrowings are secured by a fixed and floating charge over the whole undertaking of the Company, its property, assets and rights in favour of Northern Bank Ltd trading as Danske Bank.

   9              Retirement benefits obligations 

The Company operates a defined contribution scheme, the assets of which are managed separately from the Company.

   10           Transactions with related parties 

The Company had the following transactions with related parties during the period:

Invest Northern Ireland is a shareholder in the Company. The Company received invoices for rent and estate services amounting to GBP38,000 (6 months ended 30 September 2022: GBP42,000, year ended 31 March 2023: GBP79,000). There was no balance due and payable to Invest NI at the reporting dates presented.

   11           Events after the reporting date 

The Company was pleased to announce on 28(th) November 2023 that an agreement had been established with the National Cancer Institute to help validate the OptiMAL (R) platform.

   12           Reconciliation of loss to EBITDA and EBITDA excluding R&D expenditure 
 
                                      6 months       6 months     Year to 
                                   to 30.09.23    to 30.09.22    31.03.23 
                                     Unaudited      Unaudited     Audited 
                                       GBP'000        GBP'000     GBP'000 
-------------------------------  -------------  -------------  ---------- 
 Loss before tax                       (1,357)        (1,262)     (2,859) 
 Finance income/ expense                     1              6           1 
 Depreciation and amortisation             125            248         372 
-------------------------------  -------------  -------------  ---------- 
 EBITDA                                (1,231)        (1,008)     (2,486) 
 Expenditure on research and 
  development                              182            452         807 
-------------------------------  -------------  -------------  ---------- 
 EBITDA excluding research and 
  development                          (1,049)          (556)       1,679 
-------------------------------  -------------  -------------  ---------- 
 

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END

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December 04, 2023 02:00 ET (07:00 GMT)

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