RNS Number:9679H
Osmetech PLC
25 February 2003



                                  Osmetech plc

                              Directors Interests

On 24 February 2003, the Company granted options under its EMI Plan over
ordinary shares of 1p each in the capital of the Company ("Ordinary Shares") to
Mr. James White and Mr. David Sandilands, both directors of the Company.

Mr. White has been awarded options over 20,000,000 Ordinary Shares and Mr.
Sandilands options over 10,000,000 Ordinary Shares which are exercisable at
2.39p per Ordinary Share. These options are only exercisable if certain
performance criteria relating to the strategic and commercial goals of the
Company are achieved. The options are exercisable between the first and tenth
anniversary of grant subject to meeting these performance criteria. No
consideration has been paid for the grant of the options.

On 24 February 2003 Mr. White and Mr. Sandilands surrendered options over
8,247,265 Ordinary Shares and 4,769,565 Ordinary Shares respectively. Following
this surrender and the grant of options over Ordinary Shares set out above Mr.
White has a total of 25,120,000 options over Ordinary Shares and Mr. Sandilands
has options over 12,500,000 Ordinary Shares.





Enquiries

Osmetech

James White, Chief Executive       01270 216 444

Bell Pottinger Financial

Charles Reynolds                   020 7861 3871

Matthew Moth                       020 7861 3882




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