By Val Brickates Kennedy

Drug stocks gained ground Friday, with Bayer AG, Johnson & Johnson and Merck & Co. among the session's biggest winners.

The Amex Pharmaceutical Index (DRG) jumped 1% to 239.01. The Amex Biotechnology Index (BTK), meanwhile, echoed the broader market, slipping 0.3% to 626.43. The Dow Jones Industrial Average was down 25 points to 7,370.

Advances were made by several of the major U.S. pharmaceutical players, including Johnson & Johnson, Merck & Co. (MRK), Eli Lilly & Co. (LLY) and Schering-Plough Corp. (SGP). Both J&J and Merck are Dow components.

Shares of J&J rose 3% to $51.57 while Bayer (BAYRY) shares motored up 9% to $50.76.

Late Thursday, an advisory panel of the Food and Drug Administration recommended the agency approve J&J's and Bayer's new blood thinner Xarelto, despite some safety concerns. Xarelto is already on the market in Europe.

While the FDA is not bound to the recommendations of its panels, it generally follows them.

Bayer shares were pounded earlier in the week over concerns that the panel might turn down the product.

Shares of J&J were also helped by an upgrade from analysts at UBS, who raised their rating to buy from neutral. UBS cited the probable approval of Xarelto, which they believe could become a major product in the surgical market. While UBS sees 2009 as being a rather "tough year" for J&J, they foresee newer products boosting the conglomerate's top line starting in 2010.

Merck & Co. (MRK) shares climbed 2% to $26.60. Early Friday, analysts at Cowen & Co. raised their rating of the stock to outperform, citing its comparatively strong financial position and upcoming merger with Schering-Plough Corp. (SGP).

"Merck's merger with Schering-Plough makes good strategic sense across current products and those in the pipeline. The deal structure maintains Merck's tax rate, credit rating and should retain ownership of Schering-Plough's share of Remicade/Simponi," wrote the Cowen analysts, in their note.

The Cowen analysts also gave Merck the advantage in any possible legal arbitration with Remicade's and Simponi's co-marketer, Johnson & Johnson. Simponi is the prospective brand name for Remicade's successor golimumab, which is not yet on the market.

Shares of Shire Ltd. (SHPGY) fell 2% and Noven Pharmaceuticals (NOVN) dropped 4% on news that they were doing a limited recall on their product Daytrana, a patch used to treat attention deficit hyperactivity disorder.

The companies said the recall was due to problems with the product's adhesive backing rather than over any safety issue.

Shire also said it has filed a lawsuit against generic drugmaker Mylan Laboratories (MYL) over that company's attempts to market a generic version of Shire's drug Fosrenol in the U.S. Fosrenol is used to treat kidney disease.

Mylan shares were off 2% at $12.90.

-Val Brickates Kennedy; 415-439-6400; AskNewswires@dowjones.com