Quantum-Si Incorporated (Nasdaq: QSI) (“Quantum-Si,” “QSI” or the “Company”), The Protein Sequencing Company™, announces a newly released preprint from researchers at Northwestern University, titled "Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6." The publication demonstrates the power of combining two cutting-edge technologies, Quantum-Si’s Next-Generation Protein Sequencing™ (NGPS™) on Platinum®, and Individual Ion Mass Spectrometry (I2MS), to achieve a detailed analysis of key regions of the cytokine interleukin-6 (IL-6).

IL-6 is a key immune regulator and therapeutic target; however, its proteoform diversity can present significant analytical challenges. This study demonstrates how NGPS and I2MS provide complementary insights into the amino acid sequence, post-translational modifications, and proteoform variation of IL-6, paving the way for deeper understanding and potential therapeutic innovation.

"This preprint highlights the potential of merging Next-Generation Protein Sequencing with individual ion mass spectrometry,” said Neil Kelleher, Ph.D., Professor at Northwestern University and senior author of the study. “By combining these methods, we can capture a fuller picture of IL-6 proteoforms, which is critical for advancing therapeutic innovation."

Key Findings:

  • NGPS provided single amino acid resolution for IL-6 peptide fragments critical to receptor binding and function, resolving regions with low sequence coverage by mass spectrometry.
  • I2MS enabled intact proteoform detection and localized modifications, including glycosylation, within regions involved in IL-6 signaling.
  • Together these technologies provide high sequence coverage of overlapping and distinct regions of IL-6, offering a more comprehensive view of its structural and functional diversity.

"This study underscores the immense challenge of characterizing proteoforms, which has long been a barrier to developing novel therapies,” said Jeff Hawkins, President and Chief Executive Officer of Quantum-Si. “By integrating Next-Generation Protein Sequencing into one of the world’s leading proteomics labs, we’re enabling new insights into IL-6, to advance therapeutic research. These findings highlight the transformative potential of combining NGPS with traditional methods to explore proteoforms with single amino acid precision in complex diseases like cancer and autoimmune disorders."

To read the preprint visit: Next-Generation Protein Sequencing and individual ion mass spectrometry enable complementary analysis of interleukin-6 | Quantum-Si

About Quantum-Si Incorporated

Quantum-Si, The Protein Sequencing Company™, is focused on revolutionizing the growing field of proteomics. The Company’s Platinum® line of instruments enables Next-Gen Protein Sequencing™ that advances proteomic research, drug discovery, and diagnostics beyond what has been possible with existing proteomic tools. Learn more at quantum-si.com or follow us on LinkedIn or X.

Forward Looking Statements

This press release includes “forward-looking statements” within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. The actual results of the Company may differ from its expectations, estimates, and projections and, consequently, you should not rely on these forward-looking statements as predictions of future events. Words such as “expect,” “estimate,” “project,” “budget,” “forecast,” “anticipate,” “intend,” “plan,” “may,” “will,” “could,” “should,” “believes,” “predicts,” “potential,” “continue,” and similar expressions (or the negative versions of such words or expressions) are intended to identify such forward-looking statements. These forward-looking statements include, without limitation, the Company’s expectations with respect to future performance and development and commercialization of products and services, its anticipated cash runway and its financial guidance for the full year 2024. These forward-looking statements involve significant risks and uncertainties that could cause the actual results to differ materially from those discussed in the forward-looking statements. Most of these factors are outside the Company’s control and are difficult to predict. Factors that may cause such differences include, but are not limited to: the inability to maintain the listing of the Company’s Class A common stock on The Nasdaq Stock Market; the ability of the Company to grow and manage growth profitably and retain its key employees; the Company’s ongoing leadership transitions; changes in applicable laws or regulations; the ability of the Company to raise financing in the future; the success, cost and timing of the Company’s product development and commercialization activities; the commercialization and adoption of the Company’s existing products and the success of any product the Company may offer in the future; the potential attributes and benefits of the Company’s commercialized Platinum® protein sequencing instruments and kits and the Company’s other products once commercialized; the Company’s ability to obtain and maintain regulatory approval for its products, and any related restrictions and limitations of any approved product; the Company’s ability to identify, in-license or acquire additional technology; the Company’s ability to maintain its existing lease, license, manufacture and supply agreements; the Company’s ability to compete with other companies currently marketing or engaged in the development or commercialization of products and services that serve customers engaged in proteomic analysis, many of which have greater financial and marketing resources than the Company; the size and growth potential of the markets for the Company’s products and services, and its ability to serve those markets once commercialized, either alone or in partnership with others; the Company’s estimates regarding future expenses, future revenue, capital requirements and needs for additional financing; the Company’s financial performance; and other risks and uncertainties described under “Risk Factors” in the Company’s most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q and in the Company’s other filings with the SEC. The Company cautions that the foregoing list of factors is not exclusive. The Company cautions readers not to place undue reliance upon any forward-looking statements, which speak only as of the date made. The Company does not undertake or accept any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements to reflect any change in its expectations or any change in events, conditions, or circumstances on which any such statement is based.

Investor Contact Jeff Keyes Chief Financial Officer ir@quantum-si.com

Media Contact Katherine Atkinson SVP, Commercial Marketing media@quantum-si.com

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