RNS Number:0182O
3i Investments PLC
28 July 2003

                                                                      FORM SAR 5


Lodge with Company Announcements Office and the Panel.
A copy must also be sent to the company the shares of which are being sold.

Date of disclosure

28.07.03


DISCLOSURE UNDER NOTE 3 OF RULE 5 OF THE RULES GOVERNING SUBSTANTIAL
ACQUISITIONS OF SHARES ("SARs")

Date of sale

25.07.03


Sale of (name of company)

Profile Therapeutics  plc


1. Class of voting shares (eg ordinary shares)

Ordinary 2p shares


Number of shares/rights over shares sold

250,000                            Shares                               Rights


If rights over shares sold, as opposed to the shares themselves, specify nature
of rights


2. Resultant total holding of voting shares (and % of total voting shares in
issue)

10,241,384                                     20.84 %


Resultant total holding of rights over shares (and % of total voting shares in
issue)

                                               %

Total percentage

20.84  %


3. Party making disclosure

3i Investments plc

4. (a) Name of person selling shares or rights over shares

3i Investments plc

and, if different, beneficial owner


(b) Names of any other persons acting by agreement or understanding


Signed, for and on behalf of the party named in (3) above

(Also print name of signatory)

Simon Howard


Telephone and extension number

020 7928 3131


For full details of the SARs disclosure requirements, see Rules 3 and 5 of the
SARs.  If in doubt, contact the Panel on Takeovers and Mergers, Monitoring
Section, Tel. No: 020 7638 0129.


                      This information is provided by RNS
            The company news service from the London Stock Exchange
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