TIDMSHP 
 
 
   Director/PDMR Shareholding 
 
   January 8, 2019 -- Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") 
 
   Notification of transactions by persons discharging managerial 
responsibilities 
 
 
 
 
      Details of the person discharging managerial responsibilities 
1.     ("PDMR") / person closely associated with them ("PCA") 
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a)    Name                           Flemming Ornskov 
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2.    Reason for the notification 
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a)    Position / status              Chief Executive Officer - PDMR 
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      Initial notification / 
b)    amendment                      Initial notification 
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      Details of the issuer, emission allowance participant, 
3.     auction platform, auctioneer or auction monitor 
----  ------------------------------------------------------------------------------------------------ 
a)    Name                           Shire plc 
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b)    LEI                            54930005LQRLI2UXRQ59 
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      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
4.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                     Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code            ISIN: US82481R1068 
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                                       Exercise of Stock Appreciation Rights ("SARs") awarded 
                                        under the Shire Portfolio Share Plan ("PSP") on February 
                                        28, 2013. In accordance with the rules of the PSP 
                                        and the Co-Operation Agreement between the Company 
                                        and Takeda Pharmaceutical Company Limited dated May 
                                        8, 2018, exercise of the SARs is to be satisfied in 
                                        cash in an amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction         deductions for tax and social security contributions. 
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                                            Price(s)                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $           95.04                                    45,601 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
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e)    Date of the transaction                                                          January 3, 2019 
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f)    Place of the transaction                                                                     N/A 
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      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
5.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                Exercise of Stock Appreciation Rights ("SARs") awarded 
                                                   under the Shire Portfolio Share Plan ("PSP") on May 
                                                  2, 2013. In accordance with the rules of the PSP and 
                                                    the Co-Operation Agreement between the Company and 
                                                    Takeda Pharmaceutical Company Limited dated May 8, 
                                                 2018, exercise of the SARs is to be satisfied in cash 
                                                 in an amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction                  deductions for tax and social security contributions. 
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                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $           91.59                                    18,984 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
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f)    Place of the transaction                                                                     N/A 
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      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
6.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                Exercise of Stock Appreciation Rights ("SARs") awarded 
                                              under the Shire Portfolio Share Plan ("PSP") on February 
                                                     28, 2014. In accordance with the rules of the PSP 
                                                    and the Co-Operation Agreement between the Company 
                                                   and Takeda Pharmaceutical Company Limited dated May 
                                                   8, 2018, exercise of the SARs is to be satisfied in 
                                            cash in an amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction                  deductions for tax and social security contributions. 
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                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $          168.54                                    34,174 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
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e)    Date of the transaction                                                          January 3, 2019 
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f)    Place of the transaction                                                                     N/A 
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      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
7.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Voluntary cancellation of Stock Appreciation Rights 
                                                  ("SARs") awarded under the Shire Long Term Incentive 
                                                    Plan 2015 on April 30, 2015, in consideration of a 
                                                  cash payment from the Company per ADS subject to the 
                                               SAR, net of any necessary deductions for tax and social 
                                           security contributions, in accordance with the Co-Operation 
                                               Agreement between the Company and Takeda Pharmaceutical 
b)    Nature of the transaction                                     Company Limited dated May 8, 2018. 
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                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $            7.69                                    10,031 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
8.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                Exercise of Stock Appreciation Rights ("SARs") awarded 
                                                under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                    on February 26, 2016. In accordance with the rules 
                                                    of the LTIP and the Co-Operation Agreement between 
                                                 the Company and Takeda Pharmaceutical Company Limited 
                                                                         ("Takeda") dated May 8, 2018: 
                                        1.    vesting of the SARs was accelerated relative to the 
                                              normal vesting date resultant of the Royal Court of 
                                              Jersey's sanctioning of the scheme of arrangement 
                                              governing the acquisition of the Company by Takeda; 
 
                                        2.    applicable performance conditions were achieved at a 
                                              level of 100%; 
 
                                        3.    exercise of the SARs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $          161.42                                    43,329 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
9.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Vesting of Performance Stock Units ("PSUs") awarded 
                                                under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                    on February 26, 2016. In accordance with the rules 
                                                    of the LTIP and the Co-Operation Agreement between 
                                                 the Company and Takeda Pharmaceutical Company Limited 
                                                                         ("Takeda") dated May 8, 2018: 
                                        1.    vesting of the PSUs was accelerated relative to the 
                                              normal vesting date resultant of the Royal Court of 
                                              Jersey's sanctioning of the scheme of arrangement 
                                              governing the acquisition of the Company by Takeda; 
 
                                        2.    applicable performance conditions were achieved at a 
                                              level of 100%; 
 
                                        3.    the number of PSUs vesting was increased by an amount 
                                              equivalent to the value of dividends paid by the 
                                              Company in respect of the vesting PSUs from the award 
                                              date to the date of vesting; 
 
                                        4.    vesting of the PSUs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                    33,023 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
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f)    Place of the transaction                                                                     N/A 
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      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
10.    where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                    Vesting of Restricted Stock Units ("RSUs") awarded 
                                                   under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                   March 11, 2016. In accordance with the rules of the 
                                                DBP and the Co-Operation Agreement between the Company 
                                                  and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                    dated May 8, 2018: 
                                        1.    vesting of the RSUs was accelerated relative to the 
                                              normal vesting date resultant of the Royal Court of 
                                              Jersey's sanctioning of the scheme of arrangement 
                                              governing the acquisition of the Company by Takeda; 
 
                                        2.    the number of RSUs vesting was increased by an amount 
                                              equivalent to the value of dividends paid by the 
                                              Company in respect of the vesting RSUs from the award 
                                              date to the date of vesting; 
 
                                        3.    vesting of the RSUs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                     4,313 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
11.    where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Voluntary cancellation of Stock Appreciation Rights 
                                                  ("SARs") awarded under the Shire Long Term Incentive 
                                                   Plan 2015 on February 28, 2017, in consideration of 
                                                    a cash payment from the Company per ADS subject to 
                                                  the SAR, net of any necessary deductions for tax and 
                                                     social security contributions, in accordance with 
                                                    the Co-Operation Agreement between the Company and 
                                                    Takeda Pharmaceutical Company Limited dated May 8, 
                                            2018. The number of SARs outstanding prior to cancellation 
                                              was reduced to reflect the the achievement of applicable 
b)    Nature of the transaction                              performance conditions at a level of 87%. 
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                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $            5.69                                    26,566 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
12.    where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Vesting of Performance Stock Units ("PSUs") awarded 
                                                under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                    on February 28, 2017. In accordance with the rules 
                                                    of the LTIP and the Co-Operation Agreement between 
                                                 the Company and Takeda Pharmaceutical Company Limited 
                                                                         ("Takeda") dated May 8, 2018: 
                                        1.    vesting of the PSUs was accelerated relative to the 
                                              normal vesting date resultant of the Royal Court of 
                                              Jersey's sanctioning of the scheme of arrangement 
                                              governing the acquisition of the Company by Takeda; 
 
                                        2.    the number of PSUs vesting was reduced to reflect the 
                                              accelerated date of vesting relative to the normal 
                                              vesting date and the achievement of applicable 
                                              performance conditions at a level of 87%; 
 
                                        3.    the number of PSUs vesting was increased by an amount 
                                              equivalent to the value of dividends paid by the 
                                              Company in respect of the vesting PSUs from the award 
                                              date to the date of vesting; 
 
                                        4.    vesting of the PSUs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                    13,441 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
13.    where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                    Vesting of Restricted Stock Units ("RSUs") awarded 
                                                   under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                   March 10, 2017. In accordance with the rules of the 
                                                DBP and the Co-Operation Agreement between the Company 
                                                  and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                    dated May 8, 2018: 
                                        1.    vesting of the RSUs was accelerated relative to the 
                                              normal vesting date resultant of the Royal Court of 
                                              Jersey's sanctioning of the scheme of arrangement 
                                              governing the acquisition of the Company by Takeda; 
 
                                        2.    the number of RSUs vesting was increased by an amount 
                                              equivalent to the value of dividends paid by the 
                                              Company in respect of the vesting RSUs from the award 
                                              date to the date of vesting; 
 
                                        3.    vesting of the RSUs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                     3,765 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
14.    where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                    Vesting of Restricted Stock Units ("RSUs") awarded 
                                                   under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                    March 9, 2018. In accordance with the rules of the 
                                                DBP and the Co-Operation Agreement between the Company 
                                                  and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                    dated May 8, 2018: 
                                        1.    vesting of the RSUs was accelerated relative to the 
                                              normal vesting date resultant of the Royal Court of 
                                              Jersey's sanctioning of the scheme of arrangement 
                                              governing the acquisition of the Company by Takeda; 
 
                                        2.    the number of RSUs vesting was increased by an amount 
                                              equivalent to the value of dividends paid by the 
                                              Company in respect of the vesting RSUs from the award 
                                              date to the date of vesting; 
 
                                        3.    vesting of the RSUs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                     3,512 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
15.    where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Vesting of Performance Stock Units ("PSUs") awarded 
                                                under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                   on May 1, 2018. In accordance with the rules of the 
                                               LTIP and the Co-Operation Agreement between the Company 
                                                  and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                    dated May 8, 2018: 
                                        1.    vesting of the PSUs was accelerated relative to the 
                                              normal vesting date resultant of the Royal Court of 
                                              Jersey's sanctioning of the scheme of arrangement 
                                              governing the acquisition of the Company by Takeda; 
 
                                        2.    the number of PSUs vesting was reduced to reflect the 
                                              accelerated date of vesting relative to the normal 
                                              vesting date; 
 
                                        3.    applicable performance conditions were achieved at a 
                                              level of 100%; 
 
                                        4.    the number of PSUs vesting was increased by an amount 
                                              equivalent to the value of dividends paid by the 
                                              Company in respect of the vesting PSUs from the award 
                                              date to the date of vesting; 
 
                                        5.    vesting of the PSUs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                    14,941 
----  -----------------------------  -------  --------------  ---------------------------------------- 
d)    Aggregated information         N/A (single transaction) 
       - Aggregated volume - Price 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ----------------------------------------------------------------- 
 
 
 
 
 
 
     Details of the person discharging managerial responsibilities 
1.    ("PDMR") / person closely associated with them ("PCA") 
---  ------------------------------------------------------------------------------------------------- 
a)   Name                           Thomas Dittrich 
---  -----------------------------  ------------------------------------------------------------------ 
2.   Reason for the notification 
---  ------------------------------------------------------------------------------------------------- 
a)   Position / status              Chief Financial Officer - PDMR 
---  -----------------------------  ------------------------------------------------------------------ 
     Initial notification / 
b)   amendment                      Initial notification 
---  -----------------------------  ------------------------------------------------------------------ 
     Details of the issuer, emission allowance participant, 
3.    auction platform, auctioneer or auction monitor 
---  ------------------------------------------------------------------------------------------------- 
a)   Name                           Shire plc 
---  -----------------------------  ------------------------------------------------------------------ 
b)   LEI                            54930005LQRLI2UXRQ59 
---  -----------------------------  ------------------------------------------------------------------ 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
4.    where transactions have been conducted 
---  ------------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
     instrument                      Shares") 
--- 
a)   Identification code            ISIN: JE00B2QKY057 
---  -----------------------------  ------------------------------------------------------------------ 
                                      Vesting of Performance Stock Units ("PSUs") awarded 
                                       under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                       on March 29, 2018. In accordance with the rules of 
                                       the LTIP and the Co-Operation Agreement between the 
                                       Company and Takeda Pharmaceutical Company Limited 
                                       ("Takeda") dated May 8, 2018: 
                                       1.    vesting of the PSUs was accelerated relative to the 
                                             normal vesting date resultant of the Royal Court of 
                                             Jersey's sanctioning of the scheme of arrangement 
                                             governing the acquisition of the Company by Takeda; 
 
                                       2.    the number of PSUs vesting was reduced to reflect the 
                                             accelerated date of vesting relative to the normal 
                                             vesting date; 
 
                                       3.    applicable performance conditions were achieved at a 
                                             level of 100%; 
 
                                       4.    the number of PSUs vesting was increased by an amount 
                                             equivalent to the value of dividends paid by the 
                                             Company in respect of the vesting PSUs from the award 
                                             date to the date of vesting; 
 
                                       5.    vesting of the PSUs is to be satisfied in cash in an 
                                             amount per Ordinary Share of GBP47.12, net of any 
                                             necessary deductions for tax and social security 
b)   Nature of the transaction               contributions. 
---  -----------------------------  ------------------------------------------------------------------ 
                                            Price(s)                         Volume(s) 
---  -----------------------------  ------------------------  ---------------------------------------- 
c)   Price(s) and volume(s)               GBP              0                                     2,544 
---  -----------------------------  ---------  -------------  ---------------------------------------- 
     Aggregated information 
d)    - Aggregated volume - Price   N/A (single transaction) 
---  -----------------------------  ------------------------------------------------------------------ 
e)   Date of the transaction        January 3, 2019 
---  -----------------------------  ------------------------------------------------------------------ 
f)   Place of the transaction       N/A 
---  -----------------------------  ------------------------------------------------------------------ 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
5.    where transactions have been conducted 
---  ------------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
     instrument                      Shares") 
--- 
a)   Identification code            ISIN: JE00B2QKY057 
---  -----------------------------  ------------------------------------------------------------------ 
                                      Vesting of Performance Stock Units ("PSUs") awarded 
                                       under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                       on May 1, 2018. In accordance with the rules of the 
                                       LTIP and the Co-Operation Agreement between the Company 
                                       and Takeda Pharmaceutical Company Limited ("Takeda") 
                                       dated May 8, 2018: 
 
                                       1.    vesting of the PSUs was accelerated relative to the 
                                             normal vesting date resultant of the Royal Court of 
                                             Jersey's sanctioning of the scheme of arrangement 
                                             governing the acquisition of the Company by Takeda; 
 
                                       2.    the number of PSUs vesting was reduced to reflect the 
                                             accelerated date of vesting relative to the normal 
                                             vesting date; 
 
                                       3.    applicable performance conditions were achieved at a 
                                             level of 100%; 
 
                                       4.    the number of PSUs vesting was increased by an amount 
                                             equivalent to the value of dividends paid by the 
                                             Company in respect of the vesting PSUs from the award 
                                             date to the date of vesting; 
 
                                       vesting of the PSUs is to be satisfied in cash in 
                                       an amount per Ordinary Share of GBP47.12, net of any 
b)   Nature of the transaction         necessary deductions for tax and social security contributions. 
---  -----------------------------  ------------------------------------------------------------------ 
                                            Price(s)                                         Volume(s) 
---  -----------------------------  ------------------------  ---------------------------------------- 
c)   Price(s) and volume(s)               GBP              0                                    16,854 
---  -----------------------------  ---------  -------------  ---------------------------------------- 
d)   Aggregated information         N/A (single transaction) 
      - Aggregated volume - Price 
---  -----------------------------  ------------------------------------------------------------------ 
e)   Date of the transaction        January 3, 2019 
---  -----------------------------  ------------------------------------------------------------------ 
f)   Place of the transaction       N/A 
---  -----------------------------  ------------------------------------------------------------------ 
 
 
 
 
 
 
     Details of the person discharging managerial responsibilities 
1.    ("PDMR") / person closely associated with them ("PCA") 
---  ----------------------------------------------------------------------------------------------- 
a)   Name                           Andy Busch 
---  -----------------------------  ---------------------------------------------------------------- 
2.   Reason for the notification 
---  ----------------------------------------------------------------------------------------------- 
                                    Head of Research and Development and Chief Scientific 
a)   Position / status               Officer - PDMR 
---  -----------------------------  ---------------------------------------------------------------- 
     Initial notification / 
b)   amendment                      Initial notification 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the issuer, emission allowance participant, 
3.    auction platform, auctioneer or auction monitor 
---  ----------------------------------------------------------------------------------------------- 
a)   Name                           Shire plc 
---  -----------------------------  ---------------------------------------------------------------- 
b)   LEI                            54930005LQRLI2UXRQ59 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
4.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
     instrument                      Shares") 
--- 
a)   Identification code            ISIN: JE00B2QKY057 
---  -----------------------------  ---------------------------------------------------------------- 
                                    Vesting of Restricted Stock Units ("RSUs") awarded 
                                     under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                     on March 1, 2018. In accordance with the rules of 
                                     the LTIP and the Co-Operation Agreement between the 
                                     Company and Takeda Pharmaceutical Company Limited 
                                     ("Takeda") dated May 8, 2018: 
                                     1.    vesting of the RSUs was accelerated relative to the 
                                           normal vesting dates resultant of the Royal Court of 
                                           Jersey's sanctioning of the scheme of arrangement 
                                           governing the acquisition of the Company by Takeda; 
 
                                     2.    the number of RSUs vesting was reduced to reflect the 
                                           accelerated date of vesting relative to the normal 
                                           vesting dates; 
 
                                     3.    the number of RSUs vesting was increased by an amount 
                                           equivalent to the value of dividends paid by the 
                                           Company in respect of the vesting RSUs from the award 
                                           date to the date of vesting; 
 
                                     4.    vesting of the RSUs is to be satisfied in cash in an 
                                           amount per Ordinary Share of GBP47.12, net of any 
                                           necessary deductions for tax and social security 
b)   Nature of the transaction             contributions. 
---  -----------------------------  ---------------------------------------------------------------- 
                                            Price(s)                        Volume(s) 
---  -----------------------------  ------------------------  -------------------------------------- 
c)   Price(s) and volume(s)               GBP              0                                   7,628 
---  -----------------------------  ---------  -------------  -------------------------------------- 
     Aggregated information 
d)    - Aggregated volume - Price   N/A (single transaction) 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction        January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction       N/A 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
5.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
     instrument                      Shares") 
--- 
a)   Identification code            ISIN: JE00B2QKY057 
---  -----------------------------  ---------------------------------------------------------------- 
                                    Exercise of Stock Appreciation Rights ("SARs") awarded 
                                     under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                     on March 1, 2018. In accordance with the rules of 
                                     the LTIP and the Co-Operation Agreement between the 
                                     Company and Takeda Pharmaceutical Company Limited 
                                     ("Takeda") dated May 8, 2018: 
                                     1.    vesting of the SARs was accelerated relative to the 
                                           normal vesting dates resultant of the Royal Court of 
                                           Jersey's sanctioning of the scheme of arrangement 
                                           governing the acquisition of the Company by Takeda; 
 
                                     2.    the number of SARs vesting was reduced to reflect the 
                                           accelerated date of vesting relative to the normal 
                                           vesting date; 
 
                                     3.    exercise of the SARs is to be satisfied in cash in an 
                                           amount per Ordinary Share of GBP47.12, net of any 
                                           necessary deductions for tax and social security 
b)   Nature of the transaction             contributions. 
---  -----------------------------  ---------------------------------------------------------------- 
                                            Price(s)                                       Volume(s) 
---  -----------------------------  ------------------------  -------------------------------------- 
c)   Price(s) and volume(s)               GBP          31.29                                  11,132 
---  -----------------------------  ---------  -------------  -------------------------------------- 
     Aggregated information 
d)    - Aggregated volume - Price   N/A (single transaction) 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction        January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction       N/A 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
6.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
     instrument                      Shares") 
--- 
a)   Identification code            ISIN: JE00B2QKY057 
---  -----------------------------  ---------------------------------------------------------------- 
                                    Vesting of Performance Stock Units ("PSUs") awarded 
                                     under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                     on May 1, 2018. In accordance with the rules of the 
                                     LTIP and the Co-Operation Agreement between the Company 
                                     and Takeda Pharmaceutical Company Limited ("Takeda") 
                                     dated May 8, 2018: 
                                     1.    vesting of the PSUs was accelerated relative to the 
                                           normal vesting date resultant of the Royal Court of 
                                           Jersey's sanctioning of the scheme of arrangement 
                                           governing the acquisition of the Company by Takeda; 
 
                                     2.    the number of PSUs vesting was reduced to reflect the 
                                           accelerated date of vesting relative to the normal 
                                           vesting date; 
 
                                     3.    applicable performance conditions were achieved at a 
                                           level of 100%; 
 
                                     4.    the number of PSUs vesting was increased by an amount 
                                           equivalent to the value of dividends paid by the 
                                           Company in respect of the vesting PSUs from the award 
                                           date to the date of vesting; 
 
                                     5.    vesting of the PSUs is to be satisfied in cash in an 
                                           amount per Ordinary Share of GBP47.12, net of any 
                                           necessary deductions for tax and social security 
b)   Nature of the transaction             contributions. 
---  -----------------------------  ---------------------------------------------------------------- 
                                            Price(s)                                       Volume(s) 
---  -----------------------------  ------------------------  -------------------------------------- 
c)   Price(s) and volume(s)               GBP              0                                  12,584 
---  -----------------------------  ---------  -------------  -------------------------------------- 
d)   Aggregated information         N/A (single transaction) 
      - Aggregated volume - Price 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction        January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction       N/A 
---  -----------------------------  ---------------------------------------------------------------- 
 
 
 
 
 
 
      Details of the person discharging managerial responsibilities 
1.     ("PDMR") / person closely associated with them ("PCA") 
----  --------------------------------------------------------------------------------------------------- 
a)    Name                           Joanne Cordeiro 
----  -----------------------------  -------------------------------------------------------------------- 
2.    Reason for the notification 
----  --------------------------------------------------------------------------------------------------- 
a)    Position / status              Chief Human Resources Officer - PDMR 
----  -----------------------------  -------------------------------------------------------------------- 
      Initial notification / 
b)    amendment                      Initial notification 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the issuer, emission allowance participant, 
3.     auction platform, auctioneer or auction monitor 
----  --------------------------------------------------------------------------------------------------- 
a)    Name                           Shire plc 
----  -----------------------------  -------------------------------------------------------------------- 
b)    LEI                            54930005LQRLI2UXRQ59 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
4.     where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                     Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code            ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                     Exercise of Stock Appreciation Rights ("SARs") awarded 
                                      under the Shire Portfolio Share Plan ("PSP") on February 
                                      28, 2014. In accordance with the rules of the PSP 
                                      and the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited ("Takeda") 
                                      dated May 8, 2018, exercise of the SARs is to be satisfied 
                                      in cash in an amount per ADS of $173.17, net of any 
b)    Nature of the transaction       necessary deductions for tax and social security contributions. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $           168.54                                        772 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                               N/A (single transaction) 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction                                                             January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction                                                                        N/A 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
5.     where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                            Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                              ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                                      Voluntary cancellation of Stock Appreciation Rights 
                                                     ("SARs") awarded under the Shire Long Term Incentive 
                                                      Plan 2015 on February 27, 2015, in consideration of 
                                                       a cash payment from the Company per ADS subject to 
                                                     the SAR, net of any necessary deductions for tax and 
                                                        social security contributions, in accordance with 
                                                       the Co-Operation Agreement between the Company and 
                                                       Takeda Pharmaceutical Company Limited dated May 8, 
b)    Nature of the transaction                                                                     2018. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $             7.68                                      1,934 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                               N/A (single transaction) 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction                                                             January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction                                                                        N/A 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
6.     where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                            Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                              ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                                   Exercise of Stock Appreciation Rights ("SARs") awarded 
                                                   under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                       on February 26, 2016. In accordance with the rules 
                                                       of the LTIP and the Co-Operation Agreement between 
                                                    the Company and Takeda Pharmaceutical Company Limited 
                                                                            ("Takeda") dated May 8, 2018: 
                                      1.    vesting of certain of the SARs was accelerated 
                                            relative to the normal vesting dates resultant of the 
                                            Royal Court of Jersey's sanctioning of the scheme of 
                                            arrangement governing the acquisition of the Company 
                                            by Takeda; 
 
                                      2.    exercise of the SARs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $           161.42                                      3,495 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                               N/A (single transaction) 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction                                                             January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction                                                                        N/A 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
7.     where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                            Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                              ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                                      Voluntary cancellation of Stock Appreciation Rights 
                                                     ("SARs") awarded under the Shire Long Term Incentive 
                                                      Plan 2015 on February 28, 2017, in consideration of 
                                                       a cash payment from the Company per ADS subject to 
                                                     the SAR, net of any necessary deductions for tax and 
                                                        social security contributions, in accordance with 
                                                       the Co-Operation Agreement between the Company and 
                                                       Takeda Pharmaceutical Company Limited dated May 8, 
b)    Nature of the transaction                                                                     2018. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $             5.69                                      3,896 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                               N/A (single transaction) 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction                                                             January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction                                                                        N/A 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
8.     where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                            Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                              ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                                      Vesting of Performance Stock Units ("PSUs") awarded 
                                                   under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                       on February 28, 2017. In accordance with the rules 
                                                       of the LTIP and the Co-Operation Agreement between 
                                                    the Company and Takeda Pharmaceutical Company Limited 
                                                                            ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the PSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of PSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date and the achievement of applicable 
                                            performance conditions at a level of 87%; 
 
                                      3.    the number of PSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting PSUs from the award 
                                            date to the date of vesting; 
 
                                      4.    vesting of the PSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $                0                                        346 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                               N/A (single transaction) 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction                                                             January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction                                                                        N/A 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
9.     where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                            Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                              ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                                       Vesting of Restricted Stock Units ("RSUs") awarded 
                                                   under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                       on February 28, 2017. In accordance with the rules 
                                                       of the LTIP and the Co-Operation Agreement between 
                                                    the Company and Takeda Pharmaceutical Company Limited 
                                                                            ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date; 
 
                                      3.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      4.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $                0                                        139 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                               N/A (single transaction) 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction                                                             January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction                                                                        N/A 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
10.    where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                            Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                              ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                                       Vesting of Restricted Stock Units ("RSUs") awarded 
                                                   under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                      on August 24, 2017. In accordance with the rules of 
                                                      the LTIP and the Co-Operation Agreement between the 
                                                        Company and Takeda Pharmaceutical Company Limited 
                                                                            ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date; 
 
                                      3.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      4.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $                0                                        939 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                               N/A (single transaction) 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction                                                             January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction                                                                        N/A 
----  -----------------------------  -------------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
11.    where transactions have been conducted 
----  --------------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                            Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                              ISIN: US82481R1068 
----  -----------------------------  -------------------------------------------------------------------- 
                                                       Vesting of Restricted Stock Units ("RSUs") awarded 
                                                      under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                       March 9, 2018. In accordance with the rules of the 
                                                   DBP and the Co-Operation Agreement between the Company 
                                                     and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                       dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  -------------------------------------------------------------------- 
                                             Price(s)                                           Volume(s) 
----  -----------------------------  -------------------------  ----------------------------------------- 
c)    Price(s) and volume(s)                $                0                                        825 
----  -----------------------------  --------  ---------------  ----------------------------------------- 
d)    Aggregated information         N/A (single transaction) 
       - Aggregated volume - Price 
----  -----------------------------  -------------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  -------------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  -------------------------------------------------------------------- 
 
 
 
 
 
 
      Details of the person discharging managerial responsibilities 
1.     ("PDMR") / person closely associated with them ("PCA") 
----  ---------------------------------------------------------------------------------------------- 
a)    Name                           Bill Mordan 
----  -----------------------------  --------------------------------------------------------------- 
2.    Reason for the notification 
----  ---------------------------------------------------------------------------------------------- 
a)    Position / status              General Counsel and Company Secretary - PDMR 
----  -----------------------------  --------------------------------------------------------------- 
      Initial notification / 
b)    amendment                      Initial notification 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the issuer, emission allowance participant, 
3.     auction platform, auctioneer or auction monitor 
----  ---------------------------------------------------------------------------------------------- 
a)    Name                           Shire plc 
----  -----------------------------  --------------------------------------------------------------- 
b)    LEI                            54930005LQRLI2UXRQ59 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
4.     where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                     Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code            ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                     Exercise of Stock Appreciation Rights ("SARs") awarded 
                                      under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                      on February 12, 2016. In accordance with the rules 
                                      of the LTIP and the Co-Operation Agreement between 
                                      the Company and Takeda Pharmaceutical Company Limited 
                                      ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the SARs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    exercise of the SARs is to be satisfied in cash in an 
                                            amount per ADS $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $         154.95                                     6,147 
----  -----------------------------  ------  -------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                          N/A (single transaction) 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction                                                        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction                                                                   N/A 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
5.     where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                       Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                         ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                              Exercise of Stock Appreciation Rights ("SARs") awarded 
                                              under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                  on February 26, 2016. In accordance with the rules 
                                                  of the LTIP and the Co-Operation Agreement between 
                                               the Company and Takeda Pharmaceutical Company Limited 
                                                                       ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the SARs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    exercise of the SARs is to be satisfied in cash in an 
                                            amount per ADS $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $         161.42                                     9,680 
----  -----------------------------  ------  -------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                          N/A (single transaction) 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction                                                        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction                                                                   N/A 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
6.     where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                       Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                         ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                                  Vesting of Restricted Stock Units ("RSUs") awarded 
                                                 under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                 March 11, 2016. In accordance with the rules of the 
                                              DBP and the Co-Operation Agreement between the Company 
                                                and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                  dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $              0                                       157 
----  -----------------------------  ------  -------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                          N/A (single transaction) 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction                                                        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction                                                                   N/A 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
7.     where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                       Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                         ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                                 Voluntary cancellation of Stock Appreciation Rights 
                                                ("SARs") awarded under the Shire Long Term Incentive 
                                                 Plan 2015 on February 28, 2017, in consideration of 
                                                  a cash payment from the Company per ADS subject to 
                                                the SAR, net of any necessary deductions for tax and 
                                                   social security contributions, in accordance with 
                                                  the Co-Operation Agreement between the Company and 
                                                  Takeda Pharmaceutical Company Limited dated May 8, 
b)    Nature of the transaction                                                                2018. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $           5.69                                     9,415 
----  -----------------------------  ------  -------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                          N/A (single transaction) 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction                                                        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction                                                                   N/A 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
8.     where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                       Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                         ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                                 Vesting of Performance Stock Units ("PSUs") awarded 
                                              under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                  on February 28, 2017. In accordance with the rules 
                                                  of the LTIP and the Co-Operation Agreement between 
                                               the Company and Takeda Pharmaceutical Company Limited 
                                                                       ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the PSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of PSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date and the achievement of applicable 
                                            performance conditions at a level of 87%; 
 
                                      3.    the number of PSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting PSUs from the award 
                                            date to the date of vesting; 
 
                                      4.    vesting of the PSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $              0                                     5,140 
----  -----------------------------  ------  -------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                          N/A (single transaction) 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction                                                        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction                                                                   N/A 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
9.     where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                       Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                         ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                                  Vesting of Restricted Stock Units ("RSUs") awarded 
                                                 under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                 March 10, 2017. In accordance with the rules of the 
                                              DBP and the Co-Operation Agreement between the Company 
                                                and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                  dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $              0                                       869 
----  -----------------------------  ------  -------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                          N/A (single transaction) 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction                                                        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction                                                                   N/A 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
10.    where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                       Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                         ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                                  Vesting of Restricted Stock Units ("RSUs") awarded 
                                                 under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                  March 9, 2018. In accordance with the rules of the 
                                              DBP and the Co-Operation Agreement between the Company 
                                                and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                  dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $              0                                     1,039 
----  -----------------------------  ------  -------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                          N/A (single transaction) 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction                                                        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction                                                                   N/A 
----  -----------------------------  --------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
11.    where transactions have been conducted 
----  ---------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of 
      instrument                                       Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                         ISIN: US82481R1068 
----  -----------------------------  --------------------------------------------------------------- 
                                                 Vesting of Performance Stock Units ("PSUs") awarded 
                                              under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                 on May 1, 2018. In accordance with the rules of the 
                                             LTIP and the Co-Operation Agreement between the Company 
                                                and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                  dated May 8, 2018: 
                                      1.    vesting of the PSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of PSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date; 
 
                                      3.    applicable performance conditions were achieved at a 
                                            level of 100%; 
 
                                      4.    the number of PSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting PSUs from the award 
                                            date to the date of vesting; 
 
                                      5.    vesting of the PSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  --------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
----  -----------------------------  ---------------------  ---------------------------------------- 
c)    Price(s) and volume(s)              $              0                                     5,060 
----  -----------------------------  ------  -------------  ---------------------------------------- 
d)    Aggregated information         N/A (single transaction) 
       - Aggregated volume - Price 
----  -----------------------------  --------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  --------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  --------------------------------------------------------------- 
 
 
 
 
 
 
      Details of the person discharging managerial responsibilities 
1.     ("PDMR") / person closely associated with them ("PCA") 
----  ------------------------------------------------------------------------------------------------ 
a)    Name                           Perry Sternberg 
----  -----------------------------  ----------------------------------------------------------------- 
2.    Reason for the notification 
----  ------------------------------------------------------------------------------------------------ 
a)    Position / status              Head of US Commercial - PDMR 
----  -----------------------------  ----------------------------------------------------------------- 
      Initial notification / 
b)    amendment                      Initial notification 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the issuer, emission allowance participant, 
3.     auction platform, auctioneer or auction monitor 
----  ------------------------------------------------------------------------------------------------ 
a)    Name                           Shire plc 
----  -----------------------------  ----------------------------------------------------------------- 
b)    LEI                            54930005LQRLI2UXRQ59 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
4.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                     Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code            ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                     Exercise of Stock Appreciation Rights ("SARs") awarded 
                                      under the Shire Portfolio Share Plan ("PSP") on February 
                                      28, 2014. In accordance with the rules of the PSP 
                                      and the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited dated May 
                                      8, 2018, exercise of the SARs is to be satisfied in 
                                      cash in an amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction       deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $          168.54                                     1,485 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
5.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Voluntary cancellation of Stock Appreciation Rights 
                                                  ("SARs") awarded under the Shire Long Term Incentive 
                                                   Plan 2015 on February 27, 2015, in consideration of 
                                                    a cash payment from the Company per ADS subject to 
                                                  the SAR, net of any necessary deductions for tax and 
                                                     social security contributions, in accordance with 
                                                    the Co-Operation Agreement between the Company and 
                                                    Takeda Pharmaceutical Company Limited dated May 8, 
b)    Nature of the transaction                                                                  2018. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $            7.68                                     5,909 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
6.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                Exercise of Stock Appreciation Rights ("SARs") awarded 
                                                under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                    on February 26, 2016. In accordance with the rules 
                                                    of the LTIP and the Co-Operation Agreement between 
                                                 the Company and Takeda Pharmaceutical Company Limited 
                                                                         ("Takeda") dated May 8, 2018: 
                                        1.    vesting of certain of the SARs was accelerated 
                                              relative to the normal vesting dates resultant of the 
                                              Royal Court of Jersey's sanctioning of the scheme of 
                                              arrangement governing the acquisition of the Company 
                                              by Takeda; 
 
                                        2.    exercise of the SARs is to be satisfied in cash in an 
                                              amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction               deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $          161.42                                     8,896 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
7.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Voluntary cancellation of Stock Appreciation Rights 
                                                  ("SARs") awarded under the Shire Long Term Incentive 
                                                   Plan 2015 on February 28, 2017, in consideration of 
                                                    a cash payment from the Company per ADS subject to 
                                                  the SAR, net of any necessary deductions for tax and 
                                                     social security contributions, in accordance with 
                                                    the Co-Operation Agreement between the Company and 
                                                    Takeda Pharmaceutical Company Limited dated May 8, 
b)    Nature of the transaction                                                                  2018. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $            5.69                                     9,511 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
8.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                    Vesting of Restricted Stock Units ("RSUs") awarded 
                                                   under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                    March 9, 2018. In accordance with the rules of the 
                                                DBP and the Co-Operation Agreement between the Company 
                                                  and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                    dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                       719 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
9.     where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                   Vesting of Performance Stock Units ("PSUs") awarded 
                                                under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                   on May 1, 2018. In accordance with the rules of the 
                                               LTIP and the Co-Operation Agreement between the Company 
                                                  and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                    dated May 8, 2018: 
                                      1.    vesting of the PSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of PSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date; 
 
                                      3.    applicable performance conditions were achieved at a 
                                            level of 100%; 
 
                                      4.    the number of PSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting PSUs from the award 
                                            date to the date of vesting; 
 
                                      5.    vesting of the PSUs is to be satisfied in cash in an 
                                            amount per ADS of $173.17, net of any necessary 
b)    Nature of the transaction             deductions for tax and social security contributions. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                     3,979 
----  -----------------------------  -------  --------------  ---------------------------------------- 
      Aggregated information 
d)     - Aggregated volume - Price                                            N/A (single transaction) 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction                                                          January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction                                                                     N/A 
----  -----------------------------  ----------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
10.    where transactions have been conducted 
----  ------------------------------------------------------------------------------------------------ 
      Description of the financial 
      instrument, type of 
      instrument                                         Shire plc American Depositary Shares ("ADSs") 
---- 
a)    Identification code                                                           ISIN: US82481R1068 
----  -----------------------------  ----------------------------------------------------------------- 
                                                     Vesting of Restricted Stock Award ("RSA") awarded 
                                                   under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                   March 10, 2017. In accordance with the rules of the 
                                                DBP and the Co-Operation Agreement between the Company 
                                                  and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                    dated May 8, 2018: 
                                      1.    vesting of the RSA was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    as a result of the vesting of the RSA, restrictions 
                                            applying to the applicable ADSs already held will 
b)    Nature of the transaction             cease to apply. 
----  -----------------------------  ----------------------------------------------------------------- 
                                            Price(s)                                         Volume(s) 
----  -----------------------------  -----------------------  ---------------------------------------- 
c)    Price(s) and volume(s)               $               0                                       530 
----  -----------------------------  -------  --------------  ---------------------------------------- 
d)    Aggregated information         N/A (single transaction) 
       - Aggregated volume - Price 
----  -----------------------------  ----------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ----------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ----------------------------------------------------------------- 
 
 
 
 
 
 
      Details of the person discharging managerial responsibilities 
1.     ("PDMR") / person closely associated with them ("PCA") 
----  ----------------------------------------------------------------------------------------------- 
a)    Name                           Kim Stratton 
----  -----------------------------  ---------------------------------------------------------------- 
2.    Reason for the notification 
----  ----------------------------------------------------------------------------------------------- 
a)    Position / status              Head of International Commercial - PDMR 
----  -----------------------------  ---------------------------------------------------------------- 
      Initial notification / 
b)    amendment                      Initial notification 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the issuer, emission allowance participant, 
3.     auction platform, auctioneer or auction monitor 
----  ----------------------------------------------------------------------------------------------- 
a)    Name                           Shire plc 
----  -----------------------------  ---------------------------------------------------------------- 
b)    LEI                            54930005LQRLI2UXRQ59 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
4.     where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Exercise of Stock Appreciation Rights ("SARs") awarded 
                                      under the Shire Portfolio Share Plan ("PSP") on August 
                                      29, 2013. In accordance with the rules of the PSP 
                                      and the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited dated May 
                                      8, 2018, exercise of the SARs is to be satisfied in 
                                      cash in an amount per Ordinary Share of GBP47.12, 
                                      net of any necessary deductions for tax and social 
b)    Nature of the transaction       security contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                        Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP           24.00                                 9,787 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
5.     where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Exercise of Stock Appreciation Rights ("SARs") awarded 
                                      under the Shire Portfolio Share Plan ("PSP") on February 
                                      28, 2014. In accordance with the rules of the PSP 
                                      and the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited dated May 
                                      8, 2018, exercise of the SARs is to be satisfied in 
                                      cash in an amount per Ordinary Share of GBP47.12, 
                                      net of any necessary deductions for tax and social 
b)    Nature of the transaction       security contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP           33.83                                 6,590 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
6.     where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Voluntary cancellation of Stock Appreciation Rights 
                                      ("SARs") awarded under the Shire Long Term Incentive 
                                      Plan 2015 on February 27, 2015, in consideration of 
                                      a cash payment from the Company per Ordinary Share 
                                      subject to the SAR, net of any necessary deductions 
                                      for tax and social security contributions, in accordance 
                                      with the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited dated May 
b)    Nature of the transaction       8, 2018. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP            1.65                                12,623 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
7.     where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Exercise of Stock Appreciation Rights ("SARs") awarded 
                                      under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                      on February 26, 2016. In accordance with the rules 
                                      of the LTIP and the Co-Operation Agreement between 
                                      the Company and Takeda Pharmaceutical Company Limited 
                                      ("Takeda") dated May 8, 2018: 
                                      1.    vesting of certain of the SARs was accelerated 
                                            relative to the normal vesting date resultant of the 
                                            Royal Court of Jersey's sanctioning of the scheme of 
                                            arrangement governing the acquisition of the Company 
                                            by Takeda; 
 
                                      2.    exercise of the SARs is to be satisfied in cash in an 
                                            amount per Ordinary Share of GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP           38.50                                15,086 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
8.     where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Vesting of Performance Stock Units ("PSUs") awarded 
                                      under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                      on February 26, 2016. In accordance with the rules 
                                      of the LTIP and the Co-Operation Agreement between 
                                      the Company and Takeda Pharmaceutical Company Limited 
                                      ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the PSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    applicable performance conditions were achieved at a 
                                            level of 100%; 
 
                                      3.    the number of PSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting PSUs from the award 
                                            date to the date of vesting; 
 
                                      4.    vesting of the PSUs is to be satisfied in cash in an 
                                            amount per Ordinary Share of GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP               0                                 2,136 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
9.     where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Vesting of Restricted Stock Units ("RSUs") awarded 
                                      under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                      on February 26, 2016. In accordance with the rules 
                                      of the LTIP and the Co-Operation Agreement between 
                                      the Company and Takeda Pharmaceutical Company Limited 
                                      ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per Ordinary Share GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP               0                                   748 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
10.    where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Vesting of Restricted Stock Units ("RSUs") awarded 
                                      under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                      on August 5, 2016. In accordance with the rules of 
                                      the LTIP and the Co-Operation Agreement between the 
                                      Company and Takeda Pharmaceutical Company Limited 
                                      ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date(s) resultant of the Royal Court 
                                            of Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per Ordinary Share GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP               0                                  3113 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
11.    where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Voluntary cancellation of Stock Appreciation Rights 
                                      ("SARs") awarded under the Shire Long Term Incentive 
                                      Plan 2015 on February 28, 2017, in consideration of 
                                      a cash payment from the Company per Ordinary Share 
                                      subject to the SAR, net of any necessary deductions 
                                      for tax and social security contributions, in accordance 
                                      with the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited dated May 
b)    Nature of the transaction       8, 2018. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP            1.52                                26,587 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
12.    where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Vesting of Performance Stock Units ("PSUs") awarded 
                                      under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                      on February 28, 2017. In accordance with the rules 
                                      of the LTIP and the Co-Operation Agreement between 
                                      the Company and Takeda Pharmaceutical Company Limited 
                                      ("Takeda") dated May 8, 2018: 
                                      1.    vesting of the PSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of PSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date and the achievement of applicable 
                                            performance conditions at a level of 87%; 
 
                                      3.    the number of PSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting PSUs from the award 
                                            date to the date of vesting; 
 
                                      4.    vesting of the PSUs is to be satisfied in cash in an 
                                            amount per Ordinary Share of GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP               0                                14,518 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
13.    where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Vesting of Restricted Stock Units ("RSUs") awarded 
                                      under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                      March 10, 2017. In accordance with the rules of the 
                                      DBP and the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited ("Takeda") 
                                      dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per Ordinary Share of GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP               0                                 2,957 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
14.    where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Vesting of Restricted Stock Units ("RSUs") awarded 
                                      under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                      March 9, 2018. In accordance with the rules of the 
                                      DBP and the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited ("Takeda") 
                                      dated May 8, 2018: 
                                      1.    vesting of the RSUs was accelerated relative to the 
                                            normal vesting date(s) resultant of the Royal Court 
                                            of Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of RSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting RSUs from the award 
                                            date to the date of vesting; 
 
                                      3.    vesting of the RSUs is to be satisfied in cash in an 
                                            amount per Ordinary Share of GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP               0                                 3,915 
----  -----------------------------  ----------  --------------  ------------------------------------ 
      Aggregated information 
d)     - Aggregated volume - Price   N/A (single transaction) 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
      Details of the transaction(s): section to be repeated 
       for (i) each type of instrument; (ii) each type of 
       transaction; (iii) each date; and (iv) each place 
15.    where transactions have been conducted 
----  ----------------------------------------------------------------------------------------------- 
      Description of the financial 
      instrument, type of            Shire plc Ordinary Shares of 5 pence each ("Ordinary 
      instrument                      Shares") 
---- 
a)    Identification code            ISIN: JE00B2QKY057 
----  -----------------------------  ---------------------------------------------------------------- 
                                     Vesting of Performance Stock Units ("PSUs") awarded 
                                      under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                      on May 1, 2018. In accordance with the rules of the 
                                      LTIP and the Co-Operation Agreement between the Company 
                                      and Takeda Pharmaceutical Company Limited ("Takeda") 
                                      dated May 8, 2018: 
                                      1.    vesting of the PSUs was accelerated relative to the 
                                            normal vesting date resultant of the Royal Court of 
                                            Jersey's sanctioning of the scheme of arrangement 
                                            governing the acquisition of the Company by Takeda; 
 
                                      2.    the number of PSUs vesting was reduced to reflect the 
                                            accelerated date of vesting relative to the normal 
                                            vesting date; 
 
                                      3.    applicable performance conditions were achieved at a 
                                            level of 100%; 
 
                                      4.    the number of PSUs vesting was increased by an amount 
                                            equivalent to the value of dividends paid by the 
                                            Company in respect of the vesting PSUs from the award 
                                            date to the date of vesting; 
 
                                      5.    vesting of the PSUs is to be satisfied in cash in an 
                                            amount per Ordinary Share of GBP47.12, net of any 
                                            necessary deductions for tax and social security 
b)    Nature of the transaction             contributions. 
----  -----------------------------  ---------------------------------------------------------------- 
                                              Price(s)                                      Volume(s) 
----  -----------------------------  --------------------------  ------------------------------------ 
c)    Price(s) and volume(s)                GBP               0                                13,488 
----  -----------------------------  ----------  --------------  ------------------------------------ 
d)    Aggregated information         N/A (single transaction) 
       - Aggregated volume - Price 
----  -----------------------------  ---------------------------------------------------------------- 
e)    Date of the transaction        January 3, 2019 
----  -----------------------------  ---------------------------------------------------------------- 
f)    Place of the transaction       N/A 
----  -----------------------------  ---------------------------------------------------------------- 
 
 
 
 
 
 
     Details of the person discharging managerial responsibilities 
1.    ("PDMR") / person closely associated with them ("PCA") 
---  ----------------------------------------------------------------------------------------------- 
a)   Name                           Matt Walker 
---  -----------------------------  ---------------------------------------------------------------- 
2.   Reason for the notification 
---  ----------------------------------------------------------------------------------------------- 
a)   Position / status              Head of Technical Operations - PDMR 
---  -----------------------------  ---------------------------------------------------------------- 
     Initial notification / 
b)   amendment                      Initial notification 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the issuer, emission allowance participant, 
3.    auction platform, auctioneer or auction monitor 
---  ----------------------------------------------------------------------------------------------- 
a)   Name                           Shire plc 
---  -----------------------------  ---------------------------------------------------------------- 
b)   LEI                            54930005LQRLI2UXRQ59 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
4.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of 
     instrument                     Shire plc American Depositary Shares ("ADSs") 
--- 
a)   Identification code            ISIN: US82481R1068 
---  -----------------------------  ---------------------------------------------------------------- 
                                    Voluntary cancellation of Stock Appreciation Rights 
                                     ("SARs") awarded under the Shire Long Term Incentive 
                                     Plan 2015 on May 2, 2016, in consideration of a cash 
                                     payment from the Company per ADS subject to the SAR, 
                                     net of any necessary deductions for tax and social 
                                     security contributions, in accordance with the Co-Operation 
                                     Agreement between the Company and Takeda Pharmaceutical 
b)   Nature of the transaction       Company Limited dated May 8, 2018. 
---  -----------------------------  ---------------------------------------------------------------- 
                                           Price(s)                         Volume(s) 
---  -----------------------------  -----------------------  --------------------------------------- 
c)   Price(s) and volume(s)               $            5.78                                    5,162 
---  -----------------------------  -------  --------------  --------------------------------------- 
     Aggregated information 
d)    - Aggregated volume - Price                                           N/A (single transaction) 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction                                                         January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction                                                                    N/A 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
5.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of 
     instrument                                        Shire plc American Depositary Shares ("ADSs") 
--- 
a)   Identification code                                                          ISIN: US82481R1068 
---  -----------------------------  ---------------------------------------------------------------- 
                                                 Voluntary cancellation of Stock Appreciation Rights 
                                                ("SARs") awarded under the Shire Long Term Incentive 
                                                 Plan 2015 on February 28, 2017, in consideration of 
                                                  a cash payment from the Company per ADS subject to 
                                                the SAR, net of any necessary deductions for tax and 
                                                   social security contributions, in accordance with 
                                                  the Co-Operation Agreement between the Company and 
                                                  Takeda Pharmaceutical Company Limited dated May 8, 
b)   Nature of the transaction                                                                 2018. 
---  -----------------------------  ---------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
---  -----------------------------  -----------------------  --------------------------------------- 
c)   Price(s) and volume(s)               $            5.69                                    8,179 
---  -----------------------------  -------  --------------  --------------------------------------- 
     Aggregated information 
d)    - Aggregated volume - Price                                           N/A (single transaction) 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction                                                         January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction                                                                    N/A 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
6.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of 
     instrument                                        Shire plc American Depositary Shares ("ADSs") 
--- 
a)   Identification code                                                          ISIN: US82481R1068 
---  -----------------------------  ---------------------------------------------------------------- 
                                                 Vesting of Performance Stock Units ("PSUs") awarded 
                                              under the Shire Long Term Incentive Plan 2015 ("LTIP") 
                                                  on February 28, 2017. In accordance with the rules 
                                                  of the LTIP and the Co-Operation Agreement between 
                                               the Company and Takeda Pharmaceutical Company Limited 
                                                                       ("Takeda") dated May 8, 2018: 
                                     1.    vesting of the PSUs was accelerated relative to the 
                                           normal vesting date resultant of the Royal Court of 
                                           Jersey's sanctioning of the scheme of arrangement 
                                           governing the acquisition of the Company by Takeda; 
 
                                     2.    the number of PSUs vesting was reduced to reflect the 
                                           accelerated date of vesting relative to the normal 
                                           vesting date and the achievement of applicable 
                                           performance conditions at a level of 87%; 
 
                                     3.    the number of PSUs vesting was increased by an amount 
                                           equivalent to the value of dividends paid by the 
                                           Company in respect of the vesting PSUs from the award 
                                           date to the date of vesting; 
 
                                     4.    vesting of the PSUs is to be satisfied in cash in an 
                                           amount per ADS of $173.17, net of any necessary 
b)   Nature of the transaction             deductions for tax and social security contributions. 
---  -----------------------------  ---------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
---  -----------------------------  -----------------------  --------------------------------------- 
c)   Price(s) and volume(s)               $               0                                    4,466 
---  -----------------------------  -------  --------------  --------------------------------------- 
     Aggregated information 
d)    - Aggregated volume - Price                                           N/A (single transaction) 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction                                                         January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction                                                                    N/A 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
7.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of 
     instrument                                        Shire plc American Depositary Shares ("ADSs") 
--- 
a)   Identification code                                                          ISIN: US82481R1068 
---  -----------------------------  ---------------------------------------------------------------- 
                                                  Vesting of Restricted Stock Units ("RSUs") awarded 
                                                 under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                 March 10, 2017. In accordance with the rules of the 
                                              DBP and the Co-Operation Agreement between the Company 
                                                and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                  dated May 8, 2018: 
                                     1.    vesting of the RSUs was accelerated relative to the 
                                           normal vesting date resultant of the Royal Court of 
                                           Jersey's sanctioning of the scheme of arrangement 
                                           governing the acquisition of the Company by Takeda; 
 
                                     2.    the number of RSUs vesting was increased by an amount 
                                           equivalent to the value of dividends paid by the 
                                           Company in respect of the vesting RSUs from the award 
                                           date to the date of vesting; 
 
                                     3.    vesting of the RSUs is to be satisfied in cash in an 
                                           amount per ADS of $173.17, net of any necessary 
b)   Nature of the transaction             deductions for tax and social security contributions. 
---  -----------------------------  ---------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
---  -----------------------------  -----------------------  --------------------------------------- 
c)   Price(s) and volume(s)               $               0                                      418 
---  -----------------------------  -------  --------------  --------------------------------------- 
     Aggregated information 
d)    - Aggregated volume - Price                                           N/A (single transaction) 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction                                                         January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction                                                                    N/A 
---  -----------------------------  ---------------------------------------------------------------- 
     Details of the transaction(s): section to be repeated 
      for (i) each type of instrument; (ii) each type of 
      transaction; (iii) each date; and (iv) each place 
8.    where transactions have been conducted 
---  ----------------------------------------------------------------------------------------------- 
     Description of the financial 
     instrument, type of 
     instrument                                        Shire plc American Depositary Shares ("ADSs") 
--- 
a)   Identification code                                                          ISIN: US82481R1068 
---  -----------------------------  ---------------------------------------------------------------- 
                                                  Vesting of Restricted Stock Units ("RSUs") awarded 
                                                 under the Shire Deferred Bonus Plan 2015 ("DBP") on 
                                                  March 9, 2018. In accordance with the rules of the 
                                              DBP and the Co-Operation Agreement between the Company 
                                                and Takeda Pharmaceutical Company Limited ("Takeda") 
                                                                                  dated May 8, 2018: 
                                     1.    vesting of the RSUs was accelerated relative to the 
                                           normal vesting date resultant of the Royal Court of 
                                           Jersey's sanctioning of the scheme of arrangement 
                                           governing the acquisition of the Company by Takeda; 
 
                                     2.    the number of RSUs vesting was increased by an amount 
                                           equivalent to the value of dividends paid by the 
                                           Company in respect of the vesting RSUs from the award 
                                           date to the date of vesting; 
 
                                     3.    vesting of the RSUs is to be satisfied in cash in an 
                                           amount per ADS of $173.17, net of any necessary 
b)   Nature of the transaction             deductions for tax and social security contributions. 
---  -----------------------------  ---------------------------------------------------------------- 
                                           Price(s)                                        Volume(s) 
---  -----------------------------  -----------------------  --------------------------------------- 
c)   Price(s) and volume(s)               $               0                                      924 
---  -----------------------------  -------  --------------  --------------------------------------- 
d)   Aggregated information         N/A (single transaction) 
      - Aggregated volume - Price 
---  -----------------------------  ---------------------------------------------------------------- 
e)   Date of the transaction        January 3, 2019 
---  -----------------------------  ---------------------------------------------------------------- 
f)   Place of the transaction       N/A 
---  -----------------------------  ---------------------------------------------------------------- 
 
 
   For further information please contact: 
 
 
 
 
Investor Relations 
Christoph Brackmann   christoph.brackmann@shire.com   +41 41 288 41 29 
Sun Kim               sun.kim@shire.com                +1 617 588 8175 
Scott Burrows         scott.burrows@shire.com          +41 41 288 4195 
 
Media 
Katie Joyce           kjoyce@shire.com                 +1 781 482 2779 
 
 
 
   NOTES TO EDITORS 
 
   Shire is now part of Takeda. 
 
   https://www.globenewswire.com/Tracker?data=QTJyGLlBDXAlCdGi9ng8C8zXTYLzxb8nc5RW8QI6y1qGqr3ra-a8bLgECDN0-z-yKFJ23yX_xx58SN3c4m3wmg== 
www.takeda.com 
 
   www.shire.com 
 
 
 
 

(END) Dow Jones Newswires

January 08, 2019 12:45 ET (17:45 GMT)

Copyright (c) 2019 Dow Jones & Company, Inc.
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