UCBJY UCB (PK)

ATLANTA, Dec. 8, 2014 /PRNewswire/ -- The Department of Neurology at Emory University School of Medicine and UCB, a global biopharmaceutical company with a focus on epilepsy treatment and research, today announced results of the first assessment of epilepsy prevalence and incidence in the U.S. based on a large-scale analysis of insurance claims data. These results are being presented today at the 68^th Annual Meeting of the American Epilepsy Society (AES) in Seattle, Washington (December 5^th – 9^th).

Key points:

• Estimates of epilepsy prevalence and incidence have historically been based on limited data from potentially unrepresentative localities and patient populations.
• As part of a research collaboration between UCB and the Emory University Department of Neurology, researchers conducted an extensive and representative analysis of insurance claims data representing more than 20 million enrollees of all ages from across the U.S.
  • The retrospective observational analysis used Commercial Claims and Medicare (CC&M) Supplemental and Medicaid insurance claims data from 2007 to 2011.
  • Epilepsy cases were identified through ICD-9-CM-coded diagnoses of epilepsy or seizures, as well as evidence of prescribed antiepileptic drugs.
• Results showed that the overall age-adjusted prevalence estimate, combining weighted estimates from all data sets, is 8.4 cases of epilepsy per 1,000 population.
• The results also showed that the overall age-adjusted incidence estimate, combining weighted estimates from data sets, is 79.1 per 100,000 population.
  • These weighted estimates found substantially higher rates of epilepsy incidence among persons <5 or >60 years of age.
• The age-adjusted prevalence and incidence estimates for Medicaid patients were significantly higher than those of the CC&M group, respectively.
• Overall, UCB and Emory researchers were able to derive a weighted, age-adjusted estimate of epilepsy prevalence that is within the range of other estimates published from developed countries.
• The combined weighted age-adjusted estimate of annual epilepsy incidence derived from the analysis is distinctly higher than the median estimate obtained by an evidence-based review of population-based incidence studies, but shows a distribution similar to those of many other studies.

Quotes:

Sandra Helmers, M.D., M.P.H., Professor of Neurology and Pediatrics at Emory University:

• "Many people would be surprised to learn that epilepsy prevalence statistics in the U.S. were last updated in the mid-1990s.¹ By conducting the largest analysis of epilepsy prevalence to date, we now have data that can inform meaningful public health interventions to better address the burden of epilepsy on individual patients and families across the country."
• "Epilepsy's unpredictable nature presents particular challenges for both patients and physicians. Accurately quantifying the prevalence of epilepsy on a national level is critical to helping ensure optimal public health support for people living with the disease. These results are an important first step because they help inform a nationally projectable prevalence estimate."

Patty Fritz, Vice President, Corporate Affairs, UCB:

• "UCB has a longstanding heritage in epilepsy, and we are continuously looking for opportunities to improve patient care. Our innovative, hands-on collaboration with Emory reflects this commitment by leveraging real-world data to generate research that enhances our understanding of epilepsy and how many patients it impacts."
• "Both the Institute of Medicine and the epilepsy community have been calling for more rigorously documented epidemiological data, and this initial output of UCB's collaboration with Emory is an important first step. We hope that these results and future outputs of our collaboration ultimately contribute to improved patient care." 

About Epilepsy^1,2,3,4,5
Epilepsy is a chronic neurological disorder affecting approximately 65 million people worldwide and more than 2 million people in the U.S. It is the fourth most common neurological disorder in the U.S. Anyone can develop epilepsy; it occurs across all ages, races and genders and is defined as two or more unprovoked seizures that occur at least 24 hours apart.

About UCB's Research Collaborations in Epilepsy
UCB has a rich heritage in epilepsy with more than 20 years of experience in the research and development of antiepileptic drugs. As a company with a long-term commitment to epilepsy research, we partner and create super-networks with leading researchers and institutions to use cutting-edge scientific research and technology to deliver unique patient solutions. At UCB, we are inspired by patients and driven by science in our commitment to support people living with epilepsy. 

About Emory Woodruff Health Sciences Center
The Robert W. Woodruff Health Sciences Center of Emory University was founded in 1966. Its mission is to serve humanity by improving integration of education, discovery, and health care. 

The center's components include Emory University School of Medicine, Nell Hodgson Woodruff School of Nursing, Rollins School of Public Health, Yerkes National Primate Research Center, Winship Cancer Institute, and Emory Healthcare, the largest, most comprehensive health system in Georgia.

The Woodruff Health Sciences Center has $3.5 billion in operating expenditures, 23,121 employees (including 2,810 faculty), 1,371 affiliated faculty, 5,200 students and trainees, and a $6.8 billion economic impact on metro Atlanta.

For further information

• Amy Chandler Agan, UCB, T +1 770 970 8668, Amy.Agan@ucb.com
• Robin Reese, Emory, 404-727-9371, Robin.J.Reese@emory.edu

References

1. IOM (Institute of Medicine). 2012. Epilepsy across the spectrum: Promoting health and understanding. Washington, DC: The National Academies Press.
2. Epilepsy Foundation: About Epilepsy: The Basics Accessed 18th November 2014 from http://www.epilepsy.com/learn/about-epilepsy-basics 
3. Epilepsy Foundation. What is Epilepsy?. Accessed 18th November 2014 from http://www.epilepsy.com/learn/epilepsy-101/what-epilepsy
4. NINDS/NIH. Seizures and Epilepsy. Accessed 18th November 2014 from http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm#196923109   
5. St Louis, EK et al. Antiepileptic drug monotherapy: The initial approach in epilepsy management.  Curr Neuropharmacol. 2009;7(2):77-82.

About UCB
UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 8,500 people in approximately 40 countries, the company generated revenue of € 3.4 billion in 2013. UCB is listed on Euronext Brussels (symbol: UCB). Follow us on Twitter: @UCB_news

Forward looking statements
This press release contains forward-looking statements based on current plans, estimates and beliefs of management. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial information, expected legal, political, regulatory or clinical results and other such estimates and results. By their nature, such forward-looking statements are not guarantees of future performance and are subject to risks, uncertainties and assumptions which could cause actual results to differ materially from those that may be implied by such forward-looking statements contained in this press release. Important factors that could result in such differences include: changes in general economic, business and competitive conditions, the inability to obtain necessary regulatory approvals or to obtain them on acceptable terms, costs associated with research and development, changes in the prospects for products in the pipeline or under development by UCB, effects of future judicial decisions or governmental investigations, product liability claims, challenges to patent protection for products or product candidates, changes in laws or regulations, exchange rate fluctuations, changes or uncertainties in tax laws or the administration of such laws and hiring and retention of its employees. UCB is providing this information as of the date of this press release and expressly disclaims any duty to update any information contained in this press release, either to confirm the actual results or to report a change in its expectations.

There is no guarantee that new product candidates in the pipeline will progress to product approval or that new indications for existing products will be developed and approved. Products or potential products which are the subject of partnerships, joint ventures or licensing collaborations may be subject to differences between the partners. Also, UCB or others could discover safety, side effects or manufacturing problems with its products after they are marketed.

Moreover, sales may be impacted by international and domestic trends toward managed care and health care cost containment and the reimbursement policies imposed by third-party payers as well as legislation affecting biopharmaceutical pricing and reimbursement.

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/ucb-and-emory-present-new-assessment-of-epilepsy-prevalence-and-incidence-in-the-us-at-2014-american-epilepsy-society-annual-meeting-300005874.html

SOURCE UCB