PLPL Plandai Biotechnology Inc (PK)

Plandaí Biotechnology's Upcoming Clinical Trial Could Strengthen Case for Phytofare in Treatment of Diabetes

NEW YORK, NY-(Marketwired - May 18, 2017) - Plandaí Biotechnology (OTCQB: PLPL) announced that it will conduct a human clinical trial to study the effectiveness of using its highly bioavailable green tea extract, Phytofare® Catechin Complex, to regulate blood glucose levels in type 2 diabetics. If the positive data that was recently published in the Journal of Human Nutrition and Dietetics is any indicator, Plandaí should expect to receive its own positive data. The two studies could complement one another, and Plandaí's study could further strengthen the case for using green tea catechins in improving the health of type 2 diabetics.

According to an industry report, the market for diabetes drugs alone was valued at $30.95 billion in 2016, and it's expected to grow at an exponential rate and become a $44.53 billion market by 2021, at a CAGR of about 7.5%.

Obviously Plandaí would like to carve out its own space in this industry, and with a recently published study showing success with a green tea supplement that only contained 1 of the tea plant's 8 catechins, Plandaí has to feel pretty confident it can produce even better data given it can deliver all 8 catechins with its Phytofare® extract.

Catechins are known as antioxidants, and antioxidants protect the body from free radicals that are thought to play a role in everything from heart disease to cancer. Catechins are found in the greatest abundance in the leaves of the tea plant.

And we already know that Plandaí produces a product (Phytofare®) that contains all 8 of the catechins found in the tea plant. But, more importantly, Plandaí's product has proven in human clinical trials that it can deliver 10 times more of the catechins into the bloodstream and keep those antioxidants there at therapeutic levels for more than 24 hours.

Now, let's fast forward to the data from a study that was just published in the Journal of Human Nutrition and Dietetics and how Plandaí can add to that data with its clinical trial in diabetes. In that clinical trial, over 400 pregnant women, all of whom were in their third trimester and were diagnosed with gestational diabetes mellitus or "GDM," participated in investigating the effects of the catechin "epigallocatechin 3-gallate" (EGCG) on GDM in terms of both maternal and neonatal treatment outcomes.

Data from the study suggests that mothers with GDM, who were given EGCG as a supplement during the third trimester of their pregnancy, had significantly improved maternal diabetic parameters, and fewer cases of neonatal complications, compared to similar women given a placebo supplement.

One of the trial's authors, H. Zhang, said of the study, "Our current clinical trial is the first to report the potential therapeutic value of the natural compound EGCG in GDM, which is able to both alleviate maternal diabetic symptoms and reduce the incidence of neonatal complications."

A point that we can't emphasize enough from the GDM study that could benefit Plandaí greatly is that participants were given a supplement that contained only 1 of the 8 catechins, and we don't even know how bioavailable the supplement was. During Plandaí's clinical trial however, participants will be given Phytofare®, which we know will deliver all 8 catechins into the bloodstream of each participant in the study. So we expect that Plandaí's data could be extremely positive and further strengthen the research done in the GDM study.

Given how potent Phytofare® is, and how Plandaí is able to enhance the already highly bioavailable extract even more by entrapping it in liposomes, positive data from Plandaí's upcoming clinical trial in type 2 diabetes could thrust the company into the conversation, and become a real solution for how we're treating/managing type 2 diabetes worldwide.

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